Prostate Prostate PathologyPathology
Part 1Part 1
Francisco G. La Rosa, MDFrancisco G. La Rosa, MDAssociate Professor, Department of PathologyAssociate Professor, Department of Pathology
University of Colorado Denver, Aurora, ColoradoUniversity of Colorado Denver, Aurora, Colorado
NORMAL ANATOMYNORMAL ANATOMY
SAGITAL SECTION OF THE PROSTATE GLANDSAGITAL SECTION OF THE PROSTATE GLAND
SeminalVesicle
Central Zone
Bladder
Peri-urethralzone
Anterior ZoneFibro-muscular
PeripheralZone
TransitionZone
Urethra
3D VIEW OF THE PROSTATE3D VIEW OF THE PROSTATE
3D VIEW OF THE PROSTATE3D VIEW OF THE PROSTATE
CROSS SECTION OF THE PROSTATECROSS SECTION OF THE PROSTATE
FIBROMUSCULAR STROMAanterior
PERI-URETHRALSTROMA
EJACULATORY DUCTS
TRANZITIONALZONE
Seminal Vesicle
Urethra
CENTRALZONE
Peripheral Zone
Fibro-muscular Stromaanterior
HISTOLOGYHISTOLOGY
Bad HistologyBad Histology
Peripheral ZonePeripheral Zone
Central ZoneCentral Zone
Central ZoneCentral Zone
Central ZoneCentral Zone
Central ZoneCentral Zone
Central ZoneCentral Zone
40X40X Seminal VesiclesSeminal Vesicles
20X Seminal VesiclesSeminal Vesicles
20X20X Seminal VesiclesSeminal Vesicles
ParaganglionParaganglion
NeuronsNeurons40X40X
Benign Benign Lesions Lesions
InflammationInflammation
Acute InflammationAcute Inflammation
Acute InflammationAcute Inflammation
Acute InflammationAcute Inflammation
Acute InflammationAcute Inflammation
GranulomaGranuloma
20X20X Corpora AmylaceaCorpora Amylacea
20X20X Corpora AmylaceaCorpora AmylaceaCalcifiedCalcified
200X200X CristalloidCristalloid
200X200X Stromal NodulesStromal Nodules
H Y P E R P L A S I AH Y P E R P L A S I A
PRIMARY NODULAR PRIMARY NODULAR HYPERPLASIAHYPERPLASIA
Cell Type
Mesenchymal
Fibroblast
Smooth Muscle
Basal Cells
Secretory Cells
Special PatternsUsual Patterns
Predominantlystromal
Predominantlyglandular
Mixed
Small CellHyperplasia
LeiomatousHyperplasia
Basal CellHyperplasia
CrybiformHyperplasia
BENIGN NODULAR HYPERPLASIA
BENIGN NODULAR HYPERPLASIABENIGN NODULAR HYPERPLASIA
BENIGN NODULAR HYPERPLASIABENIGN NODULAR HYPERPLASIA
BPH & InflammationBPH & Inflammation
BPH & InflammationBPH & Inflammation
BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA
BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA200X
200X BASAL CELL HYPERPLASIABASAL CELL HYPERPLASIA
BASAL CELL HYPERPLASIA - HMWCKBASAL CELL HYPERPLASIA - HMWCK
ATROPHYATROPHY
20X20X SIMPLE SIMPLE ATROPHYATROPHY
200X
ATROPHYATROPHY
40X ATROPHYATROPHY
10X10X CYSTIC ATROPHYCYSTIC ATROPHY
PINPIN
Prostatic Intraepithelial NeoplasiaProstatic Intraepithelial Neoplasia
Secretorycells
Lumen
Basal Cells
BasalMembrane
Normal
Dysplasia Carcinoma
Mild Moderate Severe In situ Microinvasive
Low Grade High Grade
Prostatic Intra-epithelial Neoplasia
Prostatic Intraepithelial NeoplasiaProstatic Intraepithelial Neoplasia
Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia
Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia
Prostatic Intra-epithelial NeoplasiaProstatic Intra-epithelial Neoplasia
It continues in Part 2