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Produced by the Clinical Librarian Service

Royal College/Society Guidance Adults & Older People

Blood Cardiology

Children & Neonates Community & Mental Health

Dermatology Diabetes

Digestive Education & Training

Head & Neck Healthcare Workers

Imaging Nephrology

Neurology Obesity

Obstetrics Oncology

Ophthalmology Palliative Care

Pathology Public Health

Pulmonary/Respiratory Telehealth

Transplant Treatments

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The resources included in this update are all OpenAccess (free to use). To access resources click on the blue hyperlinks, if you are unable to read the full text of any item please contact the Clinical Librarian team If you would like a more specific search conducted that includes all evidence, including paywall restricted articles, please email the team.

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Royal College/Society Guidance Latest information and guidance

NICE Rapid guidelines and evidence summaries

Royal College of Emergency Medicine Covid-19 resources

Royal College of General Practitioners COVID-19

Royal College of Obstetrics & Gynaecologists Coronavirus (COVID-19), pregnancy and women’s health

Royal College of Paediatrics and Child Health Key topics COVID 19

Royal College of Pathologists COVID-19 Resources Hub

Royal College of Psychiatrists COVID-19: Community mental health settings

Royal College of Surgeons COVID 19 Information Hub

Royal Pharmaceutical Society COVID-19

British Society of Echocardiography COVID-19 clinical guidance

British Society of Gastroenterology COVID 19 updates

British Society for Haematology COVID-19 Updates

British Society for Rheumatology COVID-19 updates for members

Combined Intensive Care Society, Association of Anaesthetists, Royal College of Anaesthetists, Faculty of Intensive Care Medicine guidance Clinical Guidance

Adults and Older People A Simple Three-Tier Classification System for Triage, Communication, and Resource Utilization by Patients Afflicted with COVID-19 Disease Surgical Infections Letter to the editor Body temperature correlates with mortality in COVID-19 patients Critical Care Research Letter Case Report: Viral Shedding for 60 Days in a Woman with COVID-19 The American Journal of Tropical Medicine and Hygiene Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19 The Journal of Immunology Transient acute-onset tetraparesis in a COVID-19 patient Spinal Cord Correspondence

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Blood

A Case Series of MGUS and COVID‐19 British Journal of Haematology Letter

Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID‐19 pandemic British Journal of Haematology

Circulating endothelial cells in COVID ‐19 American Journal of Hematology Correspondence Coagulopathy in COVID-19 and Its Implication for Safe and Efficacious Thromboprophylaxis Hamostaseologie COVID-19 and its implications for thrombosis and anticoagulation Blood Perspective COVID-19 coagulopathy: an evolving story The Lancet Haematology Editorial Diagnosis of venous and arterial thromboembolic events in COVID-19 virus-infected patients Journal of Thrombosis and Thrombolysis

Doubtful precipitation of hemolysis by hydroxychloroquine in glucose‐6‐phosphate dehydrogenase

deficient patient with COVID‐19 infection European Journal of Haematology Letter to the editor Dysfunctional Coagulation in COVID-19: From Cell to Bedside Advances in Therapy Commentary House Calls for Stem Cell Transplants During the COVID-19 Pandemic Blood Severe exacerbation of immune thrombocytopenia and COVID-19: the favorable response to corticosteroid-based therapy—a case report Annals of Hematology Letter to the editor

Cardiology 31 days of COVID-19—cardiac events during restriction of public life—a comparative study Clinical Research in Cardiology Acute coronary syndrome in the time of the COVID-19 pandemic European Heart Journal Acute Coronary Syndromes and Covid-19: Exploring the Uncertainties Journal of Clinical Medicine

Adapting STEMI care for the COVID ‐19 pandemic: The case for low‐risk STEMI triage and early discharge Catheterization and Cardiovascular Interventions

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An educational case series of electrocardiographs during the COVID-19 pandemic and their implications on therapy Singapore Medical Journal Antihypertensive drugs in COVID-19 infection European Heart Journal Cardiovascular Pharmacotherapy Approach to Acute Cardiovascular Complications in COVID-19 Infection Circulation: Heart Failure Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study European Heart Journal Cardiovascular complications in COVID-19: A systematic review and meta-analysis Journal of Infection Review Charting a Safe and Expeditious Course Back to Elective Cardiac Surgery During the COVID-19 Pandemic Technology and Techniques in Cardiothoracic and Vascular Surgery Editorial Comparative impacts of angiotensin converting enzyme inhibitors versus angiotensin II receptor blockers on the risk of COVID-19 mortality Hypertension Considerations for Heart Failure Care During the Coronavirus Disease 2019 (COVID-19) Pandemic JACC: Heart Failure Continuation versus discontinuation of ACE inhibitors or angiotensin II receptor blockers in COVID-19: effects on blood pressure control and mortality European Heart Journal Cardiovascular Pharmacotherapy COVID-19 and cardiac arrhythmias: a global perspective on arrhythmia characteristics and management strategies Journal of Interventional Cardiac Electrophysiology COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? Heart Review COVID-19: Crisis Management in Congenital Heart Surgery World Journal for Pediatric and Congenital Heart Surgery Guidance Delivering healthcare at distance to cardiac patients during the COVID-19 pandemic: Experiences from clinical practice European Journal of Cardiovascular Nursing Incidence of New-Onset and Worsening Heart Failure Before and After the COVID-19 Epidemic Lockdown in Denmark Circulation: Heart Failure

Myocardial injury characterized by elevated cardiac troponin and in‐hospital mortality of COVID‐19: an

insight from a meta‐analysis Journal of Medical Virology Letter to the editor Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence Canadian Journal of Cardiology When a delayed cardiology consultation leads to a massive left ventricle pseudoaneurysm: collateral effects of the COVID-19 pandemic European Heart Journal

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Children & Neonates

Don’t Forget the Bubbles: An Evidence Summary of Paediatric Covid-19 Literature

A 3-month-old child with COVID-19 - A case report Medicine

A COVID‐19 outbreak's lesson: best use of the pediatric emergency department Acta Paediatrica Brief Report Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children Annals of Intensive Care Characteristic of COVID-19 infection in pediatric patients: early findings from two Italian Pediatric Research Networks European Journal of Pediatrics Short communication

Clinical Manifestations of Children with COVID‐19: a Systematic Review Pediatric Pulmonology Review COVID-19 in Children: Initial Characterization of the Pediatric Disease Pediatrics Commentary COVID-19 in children: patiently and critically evaluate the scientific evidence European Journal of Pediatrics Editorial

COVID‐19 presenting with autoimmune hemolytic anemia in the setting of underlying immune dysregulation Pediatric Blood & Cancer Letter to the editor COVID-19-Associated Myocarditis in an Adolescent The Pediatric Infectious Disease Journal Brief Report

Dermatological Manifestation of Pediatrics Multisystem Inflammatory Syndrome Associated with COVID ‐19 in a 3‐Year‐Old Girl Dermatologic Therapy Does the newly observed inflammatory syndrome in children demonstrate a link between uncontrolled neutrophil extracellular traps formation and COVID-19? Pediatric Research Correspondence SARS-CoV-2 infection in infants under 1 year of age in Wuhan City, China World Journal of Pediatrics The role of pulmonary CT scans for children during the COVID-19 pandemic BMC Medicine Commentary Understanding the age divide in COVID-19: Why are children overwhelmingly spared? American Journal of Physiology Perspective

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Using the prone position could help to combat the development of fast hypoxia in some patients with COVID‐19 Acta Paediatrica

Community and Mental Health “We are Alone in This Battle”: A Framework for a Coordinated Response to COVID-19 in Nursing Homes Journal of Aging & Social Policy A brave new world: the new normal for general practice after the COVID-19 pandemic BJGP Open A Patient with Acute Cervical Cord Injury and COVID-19 - A First Case Report American Journal of Physical Medicine & Rehabilitation Air Hunger and Psychological Trauma in Ventilated COVID-19 Patients: An Urgent Problem Annals of the American Thoracic Society Analysis of the Causes of Moral Injury in the Outbreak of 2019-nCoV Psychological Trauma: Theory, Research, Practice, and Policy Are patients with systemic lupus erythematosus at increased risk of severe COVID-19? The Journal of Rheumatology Letter Art Therapy in the Time of COVID-19 Psychological Trauma: Theory, Research, Practice, and Policy Considering Grief in Mental Health Outcomes of COVID-19 Psychological Trauma: Theory, Research, Practice, and Policy Counteracting Physical Inactivity during the COVID-19 Pandemic: Evidence-Based Recommendations for Home-Based Exercise International Journal of Environmental Research and Public Health COVID-19 – The Perfect Vector for a Mental Health Epidemic BJPsych Bulletin

COVID‐19 deaths in long term care facilities ‐ a critical piece of the pandemic puzzle Journal of the American Geriatrics Society Editorial COVID-19 effect on mental health: patients and workforce The Lancet Psychiatry Correspondence COVID-19 Emergency in the Hospital: How the Clinical Psychology Unit Is Responding Psychological Trauma: Theory, Research, Practice, and Policy COVID-19 Pandemic: Opportunity to Advanced Home Care for Older Adults Journal of Gerontological Social Work Letter to the editor COVID-19 quarantine: Post-traumatic stress symptomatology among Lebanese citizens International Journal of Social Psychiatry COVID-19: Closing the Psychological Treatment Gap during the Pandemic, a Protocol for Implementation and Evaluation of Text4Hope (a Supportive Text Message Program) JMIR Research Protocols

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COVID-19: Implications for the Support of People with Social Care Needs in England Journal of Aging & Social Policy Perspectives Deafness and Mental Health: Clinical Challenges During the COVID-19 Pandemic Psychological Trauma: Theory, Research, Practice, and Policy Development and Initial Validation of the COVID-19 Anxiety Scale Indian Journal of Public Health SARS-CoV-2 infection, clinical features and outcome of COVID-19 in United Kingdom nursing homes Journal of Infection Understanding the Mental Health Burden of COVID-19 in the United Kingdom Psychological Trauma: Theory, Research, Practice, and Policy Using Internet-based psychological measurement to capture the deteriorating community mental health profile during COVID-19: An observational study. JMIR Mental Health

Dermatology

“Thinking outside the box in COVID ‐19 era”‐Application of Modified Aerosol Box in Dermatology Dermatologic Therapy Letter Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms Inflammation Research Review

Bullous skin disease patients in a high‐epidemic COVID‐19 area, Bergamo, Italy British Journal of Dermatology Research Letter Chilblains‐like dermatologic manifestation of COVID‐19 diagnosed by serology via multidisciplinary virtual care International Journal of Dermatology Correspondence Chilblain‐like lesions during the COVID‐19 pandemic: should we really worry? International Journal of Dermatology Correspondence

Covid‐19 infection in psoriasis patients treated with cyclosporin Dermatologic Therapy Letter Clinical and histological characterization of late appearance maculopapular eruptions in association with the coronavirus disease 2019. A case series of seven patients. Journal of the European Academy of Dermatology and Venereology Letter to the editor

COVID‐19: how it can look on the skin. Clinical and pathological features in twenty COVID‐19 patients observed in Bologna, northeastern Italy Journal of the European Academy of Dermatology and Venereology Letter to the editor

Cutaneous manifestations in patients with COVID‐19: A preliminary review of an emerging issue British Journal of Dermatology Review

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Retiform purpura as a dermatological sign of covid‐19 coagulopathy Journal of the European Academy of Dermatology and Venereology Letter to the editor

Virtual dermatopathology: A potential educational tool during COVID ‐19 pandemic Dermatologic Therapy

Diabetes & Endocrinology A case of subacute thyroiditis associated with Covid-19 infection Journal of Endocrinological Investigation Letter to the editor A Pragmatic Approach to Inpatient Diabetes Management during the COVID-19 Pandemic The Journal of Clinical Endocrinology & Metabolism Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes Cell COVID-19 Pandemic Triggers Telemedicine Regulation and Intensifies Diabetes Management Technology Adoption in Brazil Journal of Diabetes Science and Technology COVID-19-associated SIADH: a clue in the times of pandemic! American Journal of Physiology, Endocrinology and Metabolism Perspective COVID-19: is there a link between the course of infection and pharmacological agents in diabetes? Journal of Endocrinological Investigation Short Review Type 1 Diabetes and COVID-19: Preliminary Findings From a Multicenter Surveillance Study in the U.S. Diabetes Care

Digestive A survey on the impact of the COVID‐19 pandemic on motility and functional investigations in Europe and considerations for recommencing activities in the early recovery phase Neurogastroenterology & Motility

A snapshot of urgent upper gastrointestinal endoscopy care during the Covid‐19 outbreak in Italy Journal of Gastroenterology and Hepatology Letter to the editor Abnormal liver tests in patients hospitalized with Coronavirus disease 2019: should we worry? Liver International Brief Report

Acro‐ischemia and COVID‐19 infection: clinical and histopathological features Journal of the European Academy of Dermatology and Venereology Letter to the editor Alterations of the Gut Microbiota in Patients with COVID-19 or H1N1 Influenza Clinical Infectious Diseases Clinical implications of COVID-19 in patients with chronic liver disease and liver tumor Updates in Surgery Editorial

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Colorectal cancer surgery during the COVID ‐19 pandemic British Journal of Surgery Letter to the editor Digestive Symptoms in COVID-19 Patients With Mild Disease Severity Clinical Presentation, Stool Viral RNA Testing, and Outcomes The American Journal of Gastroenterology

Direct endothelial damage and vasculitis due to SARS‐CoV‐2 in small bowel submucosa of CoViD‐19 patient with diarrhea Journal of Medical Virology Letter to the editor Safely restarting GI endoscopy in the era of COVID-19 Gut

Education & Training

An Online Clinical Exam for Fellowship Certification during COVID‐19 Pandemic Medical Education Approaches to stimulate clinical reasoning in continuing medical education during the COVID-19 Kardiologia Polska Short communication

Considerations for remote learning in pathology during COVID‐19 social distancing Cancer Cytopathology COVID-19 Can Catalyze the Modernization of Medical Education JMIR Medical Education Deploying Medical Students to Combat Misinformation During the COVID-19 Pandemic Academic Pediatrics

Training Oncologists in the Time of COVID ‐19 The Oncologist Commentary Virtual Read-Out: Radiology Education for the 21st Century During the COVID-19 Pandemic Academic Radiology

Head & Neck (inc. airway/ventilation) A Protection Tent for Airway Management in Patients With COVID19 Infection Annals of Emergency Medicine Correspondence A new framework to identify dental emergencies in the COVID-19 era Journal of Oral Science

Aerosol generating procedures, dysphagia assessment and COVID‐19: A rapid review International Journal of Language & Communication Disorders Alternatives to Invasive Ventilation in the COVID-19 Pandemic JAMA Editorial

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Ancillary considerations for endodontic emergency treatment of Covid‐19 positive patients Special Care in Dentistry Letter to the editor Back to the Future: Principles on Resuming Outpatient Services in the COVID-19 Era Otolaryngology–Head and Neck Surgery Commentary Care of Patients With a Laryngectomy During the COVID-19 Pandemic Otolaryngology–Head and Neck Surgery Contamination of FFP3 masks with SARS-COV-2 during endotracheal intubation Infection Control & Hospital Epidemiology COVID-19 Pandemic and Role of Human Saliva as a Testing Biofluid in Point-of-Care Technology European Journal of Dentistry Review Transnasal endoscopic skull base surgery during COVID-19 pandemic: algorithm of management in an Italian reference COVID center Acta Neurochirurgica Letter to the editor

Healthcare Workers COVID-19: 10 things I wished I’d known some months ago Intensive Care Medicine

‘Shielded’ anaesthetists and intensivists during the COVID‐19 pandemic Anaesthesia Correspondence A Tribute to Frontline Health Care Professionals During the COVID-19 Pandemic Critical Care Nurse Editorial Acidified Sodium Chlorite Solution: A Potential Prophylaxis to Mitigate Impact of Multiple Exposures to COVID-19 in Frontline Healthcare Providers Hospital Practice Editorial Asymptomatic SARS-CoV-2 Transmission from Community Contacts in Healthcare Workers Annals of Surgery Perspective Containment of a traceable COVID-19 outbreak among healthcare workers at a hematopoietic stem cell transplantation unit Bone Marrow Transplantation Correspondence Controlled, double-blind, randomized trial to assess the efficacy and safety of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in healthcare personnel in the hospital setting: A structured summary of a study protocol for a randomised controlled trial Trials Letter COVID-19 and the healthcare workers European Heart Journal COVID-19 and the Risk to Health Care Workers: A Case Report Annals of Internal Medicine Letter

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COVID-19: A personal thank you to all perioperative practitioners and other key workers Journal of Perioperative Practice Editorial COVID-19: The Worst Days of Our Careers Annals of Internal Medicine On being a doctor The psycho-emotional impact of COVID-19 on surgical staff working in emergency departments European Journal of Trauma and Emergency Surgery Letter to the editor Use of Handheld Transceiver for Hospital Healthcare Workers-Caregiver Communication During the Coronavirus disease 2019 (COVID-19) Outbreak in Pediatric Emergency Department The Pediatric Infectious Disease Journal Letter to the editor Resuming elective surgery in the time of COVID-19: a safe and comprehensive strategy Updates in Surgery

Imaging A Brief Review of Lung Ultrasonography in COVID-19: Is It Useful? Annals of Emergency Medicine Letter to the editor Alternative strategies for CT unit management during the COVID-19 pandemic: a single center experience Diagnostic and Interventional Radiology Letter to the editor Chest CT features of coronavirus disease 2019 (COVID-19) pneumonia: key points for radiologists La Radiologia Medica Chest CT-based differential diagnosis of 28 patients with suspected corona virus disease 2019 (COVID-19) British Journal of Radiology Chest Radiograph Features Predict a Favorable Outcome in Patients with COVID-19 Radiology

Clinical Potential of UTE‐MRI for Assessing COVID ‐19: Patient‐ and Lesion‐Based Comparative Analysis Journal of Magnetic Resonance Imaging Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management American Journal of Roentgenology COVID-19 pneumonia: increased choline uptake with 18F-choline PET/CT European Journal of Nuclear Medicine and Molecular Imaging Role of point-of-care ultrasound during the COVID-19 pandemic: our recommendations in the management of dialytic patients The Ultrasound Journal Review

Nephrology Disaster Response to the COVID-19 Pandemic for Patients with Kidney Disease in New York City JASN

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Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia JASN Rapid Communication Fatal Outcomes of COVID-19 in Patients with Severe Acute Kidney Injury Journal of Clinical Medicine Is the kidney a target of SARS-CoV-2? American Journal of Physiology Review

Neurology A review of pathophysiology and neuropsychiatric manifestations of COVID-19 Journal of Neurology Review Acute disseminated encephalomyelitis after SARS-CoV-2 infection Neurology, Neuroimmunology & Neuroinflammation Acute ischemic stroke and COVID-19 Cleveland Clinic Journal of Medicine

Concomitant brain arterial and venous thrombosis in a COVID‐19 patient European Journal of Neurology Letter to the editor COVID-19 associated central nervous system vasculopathy Canadian Journal of Neurological Sciences COVID ‐19 in Parkinson's Disease Patients Living in Lombardy, Italy Movement Disorders Brief Report COVID-19 in teriflunomide-treated patients with multiple sclerosis Journal of Neurology COVID-19 presenting with thalamic hemorrhage unmasking moyamoya angiopathy Canadian Journal of Neurological Sciences Cranial Neuropathies and COVID-19: Neurotropism and Autoimmunity Neurology Editorial Defining causality in COVID-19 and neurological disorders Journal of Neurology, Neurosurgery & Psychiatry Editorial Risk of COVID-19 infection in MS and neuromyelitis optica spectrum disorders Neurology Neuroimmunology & Neuroinflammation Underutilization of Healthcare for strokes during the COVID-19 outbreak International Journal of Stroke Vascular Endothelial Growth Factor (VEGF) as a Vital Target for Brain Inflammation during the COVID-19 Outbreak ACS Chemical Neuroscience

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Obesity Bariatric Surgery During COVID-19 Pandemic from Patients’ Point of View—The Results of a National Survey Journal of Clinical Medicine

COVID‐19: a lever for the recognition of obesity as a disease? The French experience Obesity Perspectives Eating disorders and obesity (ED&O) in the COVID-19 storm Eating and Weight Disorders – Studies on Anorexia, Bulimia and Obesity Editorial

Obstetrics Caring for Women Who Are Planning a Pregnancy, Pregnant, or Postpartum During the COVID-19 Pandemic JAMA

Clinical update on COVID ‐19 in pregnancy: A review article Journal of Obstetrics and Gynaecology Research COVID-19 and essential pregnant worker policies The Lancet Infectious Diseases Letter Vertical Transmission of SARS-CoV-2: What is the Optimal Definition? American Journal of Perinatology Editorial

Oncology A War on Two Fronts: Cancer Care in the Time of COVID-19 Annals of Internal Medicine Advanced renal cell carcinoma and COVID-19 — a personal perspective Nature Reviews Urology Comment COVID-19 global pandemic: options for management of gynecologic cancers. The experience in surgical management of ovarian cancer in the second highest affected Italian region International Journal of Gynecological Cancer Letter Development and Validation of a Clinical Risk Score for Intensive Care Resource Utilization After Colon Cancer Surgery: a Practical Guide to the Selection of Patients During COVID-19 Journal of Gastrointestinal Surgery Time for a Paradigm Shift in Head and Neck Cancer Management During the COVID-19 Pandemic Otolaryngology–Head and Neck Surgery Virtual Management of Cancer Patients in the Era of COVID-19 Pandemic Journal of Medical Internet Research Risk of SARS-CoV-2 infection and disease in metastatic triple-negative breast cancer patients treated with immune checkpoint inhibitors Future Medicine

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Ophthalmology Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface The Ocular Surface SARS-CoV-2 RNA detection in tears and conjunctival secretions of COVID-19 patients with conjunctivitis Journal of Infection

Palliative Care

Coronavirus disease 2019 (COVID‐19): strengthening our resolve to achieve universal palliative care International Nursing Review Early Intervention of Palliative Care in the Emergency Department During the COVID-19 Pandemic JAMA Internal Medicine Research Letter

Pathology ''Determining Host Factors Contributing to Disease Severity in a Family Cluster of 29 Hospitalized SARS‐CoV‐2 Patients: Could Genetic Factors Be Relevant in the Clinical Course of COVID‐19?'' Journal of Medical Virology

Acro‐ischemia and COVID‐19 infection: clinical and histopathological features Journal of the European Academy of Dermatology and Venereology Letter to the editor ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy Aging

Amplification of human β‐glucoronidase gene for appraising the accuracy of negative SARS‐CoV‐2 RT‐PCR results in upper respiratory tract specimens Journal of Medical Virology Letter to the editor Analytical comparisons of SARS-COV-2 detection by qRT-PCR and ddPCR with multiple primer/probe sets Emerging Microbes & Infections Letter

Analysis of clinical features and outcomes of 161 patients with severe and critical COVID‐19: A multicenter descriptive study Journal of Clinical Laboratory Analysis

Anticardiolipin antibodies and COVID‐19 ‐ A Case Report from America Journal of Medical Virology Letter to the editor Blood clots and TAM receptor signalling in COVID-19 pathogenesis Nature Reviews Immunology Comment

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Biosensors for Managing the COVID-19 Cytokine Storm: Challenges Ahead ACS Sensors Biomarkers associated with COVID-19 disease progression Critical Reviews in Clinical Laboratory Sciences Review Clearance and Persistence of SARS‐CoV‐2 RNA in COVID‐19 patients Journal of Medical Virology Short Communication Clinical performance of the Elecsys electrochemiluminescent immunoassay for the detection of SARS-CoV-2 total antibodies Clinical Chemistry Clinical Performance of the Roche SARS-CoV-2 Serologic Assay Clinical Chemistry

Comparison of SARS-CoV-2 detection in nasopharyngeal swab and saliva Journal of Infection Comparison of diagnostic accuracies of rapid serological tests and ELISA to molecular diagnostics in patients with suspected coronavirus disease 2019 presenting to the hospital Clinical Microbiology and Infection Research note Comparing the Binding Interactions in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV The Journal of Physical Chemistry Letters Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany Microbiology Resource Announcements Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2) Annals of Clinical Biochemistry: International Journal of Laboratory Medicine COVID-19 and heme oxygenase: novel insight into the disease and potential therapies Cell Stress and Chaperones Perspective COVID-19 diagnostics in context Science Translational Medicine Perspective

COVID‐19 presenting with immune thrombocytopenia: a case report and review of the literature Journal of Medical Virology Letter to the editor

COVID‐19 polyradiculitis in 24 patients without SARS‐CoV‐2 in the cerebro‐spinal fluid Journal of Medical Virology Letter to the editor COVID-19: Coronavirus replication, pathogenesis, and therapeutic strategies Cleveland Clinic Journal of Medicine Critical role of laboratory medicine in the global response to the COVID-19 pandemic Clinical Chemistry and Laboratory Medicine Cross-reactive Antibody Response between SARSCoV-2 and SARS-CoV Infections Cell Report Delayed specific IgM antibody responses observed among COVID-19 patients with severe progression Emerging Microbes & Infections

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Diagnostic testing for SARS-CoV-2 CMAJ

Diagnostic Performance of a Rapid Point of Care Test for SARS‐CoV‐2 in an Urban ED Setting Academic Emergency Medicine Discovery of G-quadruplex-forming sequences in SARS-CoV-2 Briefings in Bioinformatics Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany International Journal of Legal Medicine

Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune

cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors Allergy

SARS‐CoV‐2: A comprehensive review from pathogenicity of the virus to clinical consequences Journal of Medical Virology Review SARS-CoV-2 serology: Test, test, test, but interpret with caution! Clinical Medicine Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients Nature Communications Urinalysis parameters for predicting severity in coronavirus disease 2019 (COVID-19) Clinical Chemistry and Laboratory Medicine Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (Mpro) of SARS-CoV-2 and inhibit its activity Journal of Biomolecular Structure and Dynamics

Public Health COVID-19 versus the 1918 influenza pandemic: different virus, different age mortality patterns Journal of Travel Medicine Covid-19: an Imperative to Bridge the Gap Between Medicine And Public Health Journal of General Internal Medicine Viewpoint COViD-19: Face Mask Effectiveness, Hand Sanitizer Shortages, and Rapid Medication Therapy Trials The Senior Care Pharmacist

Pulmonary/Respiratory Abrupt deterioration and pulmonary embolism in COVID-19: a case report Royal College of Physicians Case Report: The Importance of Novel Coronavirus Disease (COVID-19) and Coinfection with Other Respiratory Pathogens in the Current Pandemic The American Journal of Tropical Medicine and Hygiene Challenges in COVID-19: is pulmonary thromboembolism related to overall severity? Infectious Diseases Letter to the editor

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Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series Critical Care Research Letter Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital European Respiratory Journal Research Letter Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China Emerging Infectious Diseases Research Letter COVID-19 and nicotine as a mediator of ACE-2 European Respiratory Journal COVID-19 and smoking: is nicotine the hidden link? European Respiratory Journal COVID-19-associated invasive pulmonary aspergillosis Annals of Intensive Care Letter to the editor Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19 European Respiratory Journal Current smoking is not associated with COVID-19 European Respiratory Journal Rethinking the respiratory paradigm of COVID-19: a ‘hole’ in the argument Intensive Care Medicine Correspondence Treatment of COVID-19-exacerbated asthma: should systemic corticosteroids be used? American Journal of Physiology Perspective Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach American Journal of Physiology Perspective

Telehealth COVID-19 pandemic: an opportunity to assess the utility of telemedicine in patients with rheumatic diseases Annals of Rheumatic Diseases Correspondence Usefulness of a Telemedicine Tool TELEA in the Management of the COVID-19 Pandemic Telemedicine and e-Health

Transplant

Case series of six kidney transplanted patients with COVID‐19 pneumonia treated with tocilizumab Transplant Infectious Disease Case Report

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Clinical Outcomes and Serologic Response in Solid Organ Transplant Recipients with COVID‐19: A Case Series from the United States American Journal of Transplantation Case Report

Controversies Regarding Shielding and Susceptibility to COVID‐19 Disease in Liver transplant Recipients in the United Kingdom Transplant Infectious Disease Letter to the editor Coronavirus Disease 2019 in an Orthotopic Liver Transplant Recipient Living with Human Immunodeficiency Virus Transplant Infectious Disease COVID-19 and kidney transplantation: an Italian Survey and Consensus Journal of Nephrology Position paper & guideline

COVID‐19 Infection in Early Post‐Operative Period after Liver Transplantation Liver Transplantation Letter to the editor Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center Transplantation

Emerging evidence to support not always "Just saying no" to SARS‐CoV‐2 positive donors American Journal of Transplantation Letter to the editor

Expedited SARS‐CoV‐2 Screening of Donors and Recipients Supports Continued Solid Organ Transplant American Journal of Transplantation Brief Communication

Failed antibody response in a renal transplant recipient with SARS‐CoV‐2 infected Transplant Infectious Disease Letter to the editor

Outcome of COVID‐19 in Liver Transplant Recipients: a Preliminary Report from Northwestern Italy Transplant Infectious Disease Short Communication Recovery from COVID‐19 following Hepatitis C, Human Immunodeficiency Virus Infection and Liver Transplantation American Journal of Transplantation Letter to the editor Renal Infarct in a COVID‐19 Positive Kidney‐Pancreas Transplant Recipient American Journal of Transplantation Case Report

Treatments A comparative study on the time to achieve negative nucleic acid testing and hospital stays between

Danoprevir and Lopinavir/Ritonavir in the treatment of patients with COVID‐19 Journal of Medical Virology ''Tociluzumab challenge: A series of cytokine storm therapy experience in hospitalized Covid‐19 pneumonia patients'' Journal of Medical Virology

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A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial Trials Letter A case report of serious haemolysis in a glucose-6-phosphate dehydrogenase-deficient COVID-19 patient receiving hydroxychloroquine Infectious Diseases Case Report Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 Postgraduate Medicine Review A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial Trials Letter A Randomized Trial of Convalescent Plasma for COVID-19—Potentially Hopeful Signals JAMA Editorial A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 NEJM ACMT Position Statement: Off-Label Prescribing during COVID-19 Pandemic Journal of Medical Toxicology Position Statement Adding Colchicine to the Antiretroviral Medication - Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled Trial Trials Letter Angiotensin II administration to COVID-19 patients is not advisable Critical Care Commentary Angiotensin converting enzyme 2 (ACE2) and COVID-19: using antihypertensive medications, pharmacogenetic considerations Future Medicine Antiviral Effects of Probiotic metabolites on COVID-19 Journal of Biomolecular Structure and Dynamics Antimicrobial use, drug-resistant infections and COVID-19 Nature Reviews Microbiology Comment

Applied Clinical Pharmacology in a Crisis – Interleukin‐6 Axis Blockade and COVID‐19 Clinical Pharmacology & Therapuetics Perspective Can Hypericum perforatum (SJW ) prevent cytokine storm in COVID ‐19 patients? Phytotherapy Research Letter to the editor

Can concomitant use of zinc and curcumin with other immunity‐boosting nutraceuticals be the arsenal against COVID ‐19? Phytotherapy Research Letter to the editor

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Can 3D printing of oral drugs help fight the current COVID-19 pandemic (and similar crisis in the future)? Expert Opinion on Drug Delivery Editorial Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19 The American Journal of Tropical Medicine and Hygiene Clinical features and outcomes of COVID-19 in patients with rheumatic diseases treated with biological and synthetic targeted therapies Annals of the Rheumatic Diseases Letter Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement Allergy Position Paper Combination antiviral therapy with lopinavir/ritonavir, arbidol and interferon-a1b for COVID-19 Antiviral Therapy Case Report COVID-19 infection in a patient with FMF: does colchicine have a protective effect? Annals of Rheumatic Diseases Letter

COVID‐19 patients benefit from early antiviral treatment: a comparative, retrospective study Journal of Medical Virology Current Perspective of Antiviral Strategies against COVID-19 ACS Infectious Diseases Cyclosporine A: a valid candidate to treat COVID-19 patients with acute respiratory failure? Critical Care Editorial Detection of SARS-CoV-2 antibodies using commercial assays and seroconversion patterns in hospitalized patients Journal of Infection Drug Repurposing for COVID-19: Ethical Considerations and Roadmaps Cambridge Quarterly of Healthcare Ethics Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial Trials Letter Tocilizumab administration in a refractory case of COVID-19 International Journal of Antimicrobial Agents Letter to the editor

Tocilizumab Administration in Patients with SARS‐CoV‐2 Infection: Subcutaneous Injection versus Intravenous Infusion Journal of Medical Virology Letter to the editor Tocilizumab: from the rheumatology practice to the fight against COVID-19, a virus infection with multiple faces Expert Opinion on Biological Therapy Editorial Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial Trials Letter

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Umbilical cord blood therapy to prevent progression of COVID-19 related pneumonia: a structured summary of a study protocol for a pilot randomised controlled trial Trials Letter Utilising Point of Care Diagnostics to Minimise Nosocomial Infection in the 2019 Novel Coronavirus (SARS-CoV-2) Pandemic QJM

Urology Androgenic hormones and the excess male mortality observed in COVID-19 patients: new convergent data World Journal of Urology Letter to the editor

Vaccine Design of multi-epitope vaccine candidate against SARS-CoV-2: a in-silico study Journal of Biomolecular Structure and Dynamics Communication SARS-CoV-2 (COVID-19) Vaccine Development and Production: An Ethical Way Forward Cambridge Quarterly of Healthcare Ethics Vaccine repurposing approach for preventing COVID 19: can MMR vaccines reduce morbidity and mortality? Human Vaccines & Immunotherapies Commentary

Miscellaneous A short, animated video to improve good COVID-19 hygiene practices: a structured summary of a study protocol for a randomized controlled trial Trials Letter Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection JAMA Viewpoint Asymptomatic carriage and transmission of SARS-CoV-2: What do we know? Canadian Journal of Anesthesia Review Audio Interview: Diagnosis and Early Treatment of Covid-19 NEJM Editorial Autoimmune and inflammatory diseases following COVID-19 Nature Reviews Rheumatology Cardiopulmonary resuscitation in COVID-19 patients Cleveland Clinic Journal of Medicine

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Case-Fatality Risk Estimates for COVID-19 Calculated by Using a Lag Time for Fatality Emerging Infectious Diseases Research Cautious handling of urine from moderate to severe COVID-19 patients American Journal of Infection Control Letter to the editor Communication Skills in the Age of COVID-19 Annals of Internal Medicine Opinion Comparison of confirmed COVID ‐19 with SARS and MERS cases ‐ Clinical characteristics, laboratory

findings, radiographic signs and outcomes: A systematic review and meta‐analysis Reviews in Medical Virology Review Covid-19 and ethnicity: it’s too early to point to healthcare provider attitudes as a cause of poorer outcomes BMJ Letter COVID-19 and non-traditional mask use: How do various materials compare in reducing the infection risk for mask wearers? Journal of Hospital Infection COVID-19 - guidance for infection prevention and control in nuclear medicine Nuclear Medicine Communications Covid-19: Validity of key studies in doubt after leading journals issue expressions of concern The BMJ News Digital health management during and beyond the COVID-19 pandemic: Opportunities, barriers, and recommendations JMIR Mental Health Does vitamin D deficiency increase the severity of COVID-19? Royal College of Physicians Timely rehabilitation for critical patients with COVID-19: another issue should not be ignored Critical Care Letter

Dynamed Plus - COVID-19 (Novel Coronavirus) Latest updates

5 JUN 2020

6,535,354 confirmed cases of coronavirus disease 2019 (COVID-19) including 387,155 deaths

worldwide reported by World Health Organization (WHO) as of June 5, 2020 (WHO Situation

Report 2020 Jun 5)

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5 JUN 2020

corticosteroids may not reduce mortality or use of mechanical ventilation, and may delay virus

clearance and increase duration of hospitalization in patients with SARS-CoV-2, SARS-CoV, or

MERS-CoV infection (Leukemia 2020 May 5 early online)

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5 JUN 2020

overall international prevalence of gastrointestinal symptoms < 10% but higher prevalence

reported in countries outside of China in patients with laboratory-confirmed COVID-19

(Gastroenterology 2020 May 5 early online)

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5 JUN 2020

in patients with perioperative COVID-19 having surgery, 30-day mortality reported in 24% and

pulmonary complication in 51% of patients (Lancet 2020 May 29 early online)

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5 JUN 2020

in adults with COVID-19 admitted to intensive care unit in New York, New York, 35% reported to

need dialysis and 26% developed arrhythmia (BMJ 2020 May 29)

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5 JUN 2020

recombinant adenovirus type-5 COVID-19 vaccine reported to be safe and induce ≥ 4-fold

increase in neutralizing antibodies by day 28 in 50%-75% of healthy adults ≤ 60 years old

(Lancet 2020 May 22 early online)

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4 JUN 2020

The study assessing hydroxycloroquine and chloroquine in patients with COVID-19 originally

published in Lancet on May 22 has been retracted due to concerns about the data and analyses

and the inability of independent reviewers to obtain the dataset for peer review (Lancet Jun 4)

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4 JUN 2020

black non-Hispanic race associated with increased risk of hospitalization for COVID-19 but

similar risk for in-hospital death compared to white non-Hispanic race in Louisiana (N Engl J

Med 2020 May 27 early online)

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3 JUN 2020

each SARS-CoV-2 infection of health-insured person admitted to hospital estimated to transmit

infection to mean 1.3-2.5 persons before mitigation measures and < 1 after mitigation measures

in Washington and California, United States (BMJ 2020 May 22)

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3 JUN 2020

23% mortality for men and 15% for women reported in insured persons hospitalized with COVID-

19 before April 10, 2020 in Washington and California, United States (BMJ 2020 May 22)

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3 JUN 2020

cumulative incidence of clinically or laboratory confirmed COVID-19 hospital admissions ranges

from 14.7 to 23.3 per 100,000 insured persons in Washington and California, United States

through April 22, 2020 (BMJ 2020 May 22)

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3 JUN 2020

method of nasopharyngeal and oropharyngeal swab sample collection for COVID-19 testing

(Head Neck 2020 May 22 early online)

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3 JUN 2020

presence of symptoms appears to have low specificity for predicting positive COVID-19 test in

healthcare workers (Acad Emerg Med 2020 May 12 early online)

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3 JUN 2020

5- and 10-day remdesivir might be associated with similar clinical improvement by day 14, and

5-day treatment might be associated with lower risk of serious adverse events in patients ≥ 12

years old hospitalized with COVID-19 pneumonia and not on mechanical ventilation (N Engl J

Med 2020 May 27 early online)

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3 JUN 2020

noninvasive mechanical ventilation has insufficient evidence to determine if more effective in

improving mortality than invasive mechanical ventilation in adults with COVID-19 (Ann Intern

Med 2020 May 22 early online)

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3 JUN 2020

World Health Organization guideline on clinical management of COVID-19 recommendations on

follow-up of patients with COVID-19 (WHO 2020 May 27)

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3 JUN 2020

World Health Organization guideline on clinical management of COVID-19 recommendations on

management of adults and children with septic shock (WHO 2020 May 27)

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3 JUN 2020

World Health Organization guideline on clinical management of COVID-19 recommendations on

management of ARDS in patients with COVID-19 (WHO 2020 May 27)

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3 JUN 2020

World Health Organization guideline on clinical management of COVID-19 (WHO 2020 May 27)

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2 JUN 2020

remdesivir may shorten time to recovery in adults hospitalized with COVID-19 with lower

respiratory tract involvement (N Engl J Med 2020 May 22 early online)

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1 JUN 2020

elevated C reactive protein, troponin, or D-dimer levels at admission associated with increased

risk of severe COVID-19 (BMJ 2020 May 22)

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1 JUN 2020

Rapid Emergency Medicine score may help predict risk of in-hospital death in critically ill adults

with COVID-19 in emergency department (Acad Emerg Med 2020 Apr 20 early online)

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1 JUN 2020

higher levels of biomarkers for inflammation and thrombosis associated with increased in-

hospital mortality in critically ill patients with COVID-19 (Lancet 2020 May 19 early online)

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1 JUN 2020

advanced age and comorbidities including obesity, chronic kidney disease, and liver disease

associated with increased risk of in-hospital death in patients with COVID-19 (BMJ 2020 May

22)

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Public Health England Topics added/updated in the last week

Number of coronavirus (COVID-19) cases and risk in the UK – updated 7 June COVID-19: management of staff and exposed patients and residents in health and social care settings – updated 6 June Health economics: a guide for public health teams – updated 5 June COVID-19: guidance on shielding and protecting people defined on medical grounds as extremely vulnerable – updated 5 June How to wear and make a cloth face covering – updated 4 June COVID-19: PHE laboratory assessments of molecular tests – updated 4 June COVID-19: guidance for sampling and for diagnostic laboratories – updated 2 June

World Health Organisation – Rolling Updates Updated guidance on maintaining essential services 1 June 2020 This guidance recommends practical actions that countries can take at national, subregional and local levels to reorganize and safely maintain access to high-quality, essential health services in the pandemic context. It also outlines sample indicators for monitoring essential health services, and describes considerations on when to stop and restart services as COVID-19 transmission recedes and surges. Maintaining essential health services: operational guidance for the COVID-19 context WHO issues new illustrated guide on psychosocial skills for COVID-19 responders 1 June 2020

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The Clinical Librarian team are here to help with evidence searches, current awareness and training with information seeking skills, critical appraisal and referencing. We can assist you remotely, at your place of work or in the library at the QuAD Centre. If you have any further enquiries please do not hesitate to get in touch. You can contact us by email at Clinical.Librarian@porthosp.nhs.uk or call extension 6042. Alternatively you can contact one of the team directly: Rebecca.Howes@portshosp.nhs.uk Aaron.Razack@porthosp.nhs.uk

Aimed at those on the frontlines of the COVID-19 response – from food store staff to employers to emergency responders – WHO has released illustrated advice for taking care of one’s own mental well-being, communicating with empathy, and helping people suffering from stress or severe distress. The Guide was developed by the Inter-Agency Standing Committee’s Mental Health and Psychosocial Support Reference Group, a collaboration of UN agencies, national and international NGOs and international agencies.

Basic Psychosocial Skills: A Guide for COVID-19 Responders IASC Reference Group on Mental Health and Psychosocial Support in Emergency

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Useful Links BMJ – latest news and resources for COVID-19 Cochrane Library Coronavirus (COVID-19): evidence relevant to critical care Elsevier - Novel Coronavirus Information Center – Elsevier European Centre for Disease Prevention and Control GOV.UK Health protection Scotland New England Journal of Medicine NHS UK Oxford University Press Patient.Info