ProbioticsProbiotics

There are up to 400 different bacterial species in the colon and the vast majority (99.9%) are strict anaerobes.

Genus Log10 bacteria per gram feces

Non-sporing anaerobes Bacteriodes spp. 10- 11 Bifidobacterium spp. 10- 11 Eubacterium spp. 9 - 11 Propionibacterium spp. 9 - 11 Veillonella spp. 5 - 8

Sporing anaerobes Clostridium spp. 5 - 9

Sporing aerobes Bacillus spp.

Microaerophiles Lactobacillus spp. 7 - 9 Streptococcus spp. 7 - 9 Enterococci 5 - 7

Facultative organisms Coliforms 7 - 9 other Enterobacteria 5 - 9

http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf

For context – Total CellsFor context – Total Cells Them ~ 100,000 Them ~ 100,000 billion. billion.

You ~ 10,000 billion.You ~ 10,000 billion.

Microbiotic therapyMicrobiotic therapy

Indications for use:Indications for use: Crohn's disease, ulcerative colitis, intestinal Crohn's disease, ulcerative colitis, intestinal

disturbances, gas and bloating, disturbances, gas and bloating, constipation, diarrhea, dysbiosis, yeast-constipation, diarrhea, dysbiosis, yeast-overgrowth, parasites, irritable bowel overgrowth, parasites, irritable bowel syndrome, autoimmune conditions, MS, syndrome, autoimmune conditions, MS, lupus, AIDS, rheumatoid arthritis, during lupus, AIDS, rheumatoid arthritis, during and post antibiotic use, post chemotherapy, and post antibiotic use, post chemotherapy, post radiation, food allergies, chronic post radiation, food allergies, chronic fatigue syndrome and pharmaceutical drug fatigue syndrome and pharmaceutical drug use.use.

The Big playersThe Big players Lactobacillus acidophilusLactobacillus acidophilus Lactobacillus acidophilus is found primarily in the small intestine Lactobacillus acidophilus is found primarily in the small intestine It produces natural antibiotics (lactocidin & acidophilin), thereby, increasing your immune system's resistance against It produces natural antibiotics (lactocidin & acidophilin), thereby, increasing your immune system's resistance against

bad bacteria and fungus i.e. Candida albicans, Salmonella, E. coli, and Staphylococcus aureus bad bacteria and fungus i.e. Candida albicans, Salmonella, E. coli, and Staphylococcus aureus It implants itself on the intestinal walls, the lining of the vagina, cervix and urethra It implants itself on the intestinal walls, the lining of the vagina, cervix and urethra For years it was assumed that Lactobacillus acidophilus was the most beneficial form of the good bacteria. For years it was assumed that Lactobacillus acidophilus was the most beneficial form of the good bacteria.

However, recent research has revealed that Lactobacillus rhamnosus is just as important for good bacteria However, recent research has revealed that Lactobacillus rhamnosus is just as important for good bacteria supplementation. supplementation.

Bifidobacterium bifidumBifidobacterium bifidum Bifidobacterium bifidum reside mainly in the mucous membrane of the large intestine and vaginal tract Bifidobacterium bifidum reside mainly in the mucous membrane of the large intestine and vaginal tract Digests lactose Digests lactose Produces the most beneficial form of lactic acid and acetic acid Produces the most beneficial form of lactic acid and acetic acid Ferments indigestible fibers which produces more energy Ferments indigestible fibers which produces more energy Synthesizes some vitamins and aids mineral absorption (calcium, magnesium and zinc) Synthesizes some vitamins and aids mineral absorption (calcium, magnesium and zinc) Inhibits the growth of Salmonella sp., Listeria, Shigella, E. coli and Clostridium per fringens by crowding out Inhibits the growth of Salmonella sp., Listeria, Shigella, E. coli and Clostridium per fringens by crowding out

these bad bacteria and eating their nutrients these bad bacteria and eating their nutrients Fights the bad bacteria in your body by lowering the intestinal pH through production of fatty acids Fights the bad bacteria in your body by lowering the intestinal pH through production of fatty acids Absorbs large quantities of ferrous ions, inhibiting the growth of bad bacteria Absorbs large quantities of ferrous ions, inhibiting the growth of bad bacteria Aids constipation and diarrhea with lactic acid production Aids constipation and diarrhea with lactic acid production

Lactobacillus rhamnosusLactobacillus rhamnosus    Lactobacillus rhamnosus is a healthier species of good bacteria and colonizes in your gut mucosa Lactobacillus rhamnosus is a healthier species of good bacteria and colonizes in your gut mucosa Relieves hypersensitivity reactions and intestinal inflamation in individuals with exzema and food allergies Relieves hypersensitivity reactions and intestinal inflamation in individuals with exzema and food allergies Excellent stability over a wide range of temperatures and pH levels Excellent stability over a wide range of temperatures and pH levels Inhibits the growth of bad bacteria Inhibits the growth of bad bacteria Enhances the immune system's resistance Enhances the immune system's resistance Demonstrated antitumor activity Demonstrated antitumor activity Prevents food allergies caused by a "leaky gut" condition Prevents food allergies caused by a "leaky gut" condition

More PlayersMore Players Lactobacillus plantarumLactobacillus plantarum

Helps produce lactolin, a natural antibiotic Helps produce lactolin, a natural antibiotic Synthesizes the amino acid, L-lysine, which is anti-viral Synthesizes the amino acid, L-lysine, which is anti-viral

Bifidobacterium infantisBifidobacterium infantis Present in the intestines of infants and adults Present in the intestines of infants and adults Present in the vaginal tract Present in the vaginal tract

Lactobacillus salivariusLactobacillus salivarius Destroys harmful bacteria Destroys harmful bacteria Aids in bowel disorders Aids in bowel disorders

Lactobacillus bulgaricusLactobacillus bulgaricus Used in fermenting natural yogurt Used in fermenting natural yogurt Produces lactic acid Produces lactic acid Provides a great environment for Lactobacilli and Bifidobacterium to grow Provides a great environment for Lactobacilli and Bifidobacterium to grow

Lactobacillus caseiLactobacillus casei Close relative to Lactobacillus acidophilus Close relative to Lactobacillus acidophilus Secretes "peptidoglycan" a recognized substance that supports the body's natural defenses Secretes "peptidoglycan" a recognized substance that supports the body's natural defenses

Lactobacillus brevisLactobacillus brevis Produces lactic acid Produces lactic acid Synthesizes Vitamins D & K Synthesizes Vitamins D & K

Streptococcus thermophilusStreptococcus thermophilus Breaks down milk products by producing lactase (helps individuals that are lactose intolerant) Breaks down milk products by producing lactase (helps individuals that are lactose intolerant) Destroys Pseudomonas sp., E. coli, Staphylococcus aureus, Salmonella sp., and Shigella Destroys Pseudomonas sp., E. coli, Staphylococcus aureus, Salmonella sp., and Shigella Produces Methanol acetone, a potent anti-pathogenic agent Produces Methanol acetone, a potent anti-pathogenic agent

Undesirable types such as E. coli, Klebsiella, Clostridium and Candida albicans.Undesirable types such as E. coli, Klebsiella, Clostridium and Candida albicans.

Prebiotics?Prebiotics?

Fructo-oligo-saccharidesFructo-oligo-saccharides

Fructo-Oligo-Saccharides (FOS) is a naturally-occurring water-soluble Fructo-Oligo-Saccharides (FOS) is a naturally-occurring water-soluble fiber from fruit and vegetables which feeds the friendly intestinal fiber from fruit and vegetables which feeds the friendly intestinal bacteria.bacteria.

FOS generaly ensure rapid establishment of the Lactobacilli in the FOS generaly ensure rapid establishment of the Lactobacilli in the upper small intestine and bifido bacteria in the lower small intestine. upper small intestine and bifido bacteria in the lower small intestine.

Some, research suggests that there may be health benefits of Some, research suggests that there may be health benefits of supplementing the diet with between 5 and l0g of FOS, supplementing the diet with between 5 and l0g of FOS,

It, HMF product, also provides naturally-occurring beta-carotene from It, HMF product, also provides naturally-occurring beta-carotene from the whole freeze-dried apricot. The apricot is used for its soothing the whole freeze-dried apricot. The apricot is used for its soothing effect on the intestinal walls (and great flavor in the powders).effect on the intestinal walls (and great flavor in the powders).

Townsend letter article Townsend letter article http://www.findarticles.com/p/articles/mi_m0ISW/is_2003_June/ai_1023http://www.findarticles.com/p/articles/mi_m0ISW/is_2003_June/ai_10237215572155

InulinInulin

InulinInulin Inulin is a multi-chain fructooligosaccharide Inulin is a multi-chain fructooligosaccharide

derived from chicory root derived from chicory root It is a chain of fructose (a carbohydrate) that is It is a chain of fructose (a carbohydrate) that is

not digestible by your body, therefore, it can not digestible by your body, therefore, it can pass through the body into the large intestine pass through the body into the large intestine where it can feed your good bacteria cells where it can feed your good bacteria cells

Some, research has suggested that Inulin (9 chain links) is Some, research has suggested that Inulin (9 chain links) is more effective than FOS (3 to 4 chain links) at feeding your more effective than FOS (3 to 4 chain links) at feeding your body's good bacteria. Also, Inulin may be better tolerated by body's good bacteria. Also, Inulin may be better tolerated by humans and bad bacteria are less likely to feed on it. humans and bad bacteria are less likely to feed on it.

Human Micro Flora HMFHuman Micro Flora HMF

Genestra Brands Genestra Brands Form SeroyalForm SeroyalNew!New! Oct 2004, all HMF probiotics contain a substantial increase in potency Oct 2004, all HMF probiotics contain a substantial increase in potency

(double) and no price increase.(double) and no price increase.

HMF Replete contains… HMF Replete contains… Lactobacillus acidophilusLactobacillus acidophilus Lactobacillus salivariusLactobacillus salivarius Bifidobacterium bifidum Bifidobacterium bifidum Bifidobacterium lactis Bifidobacterium lactis

Fructo-oligosaccharides Fructo-oligosaccharides high concentrations high concentrations

ensure rapid establishment ensure rapid establishment and dominance of probiotic and dominance of probiotic cultures in the GIcultures in the GI

Indicated during and Indicated during and following antibiotic therapy following antibiotic therapy and chemotherapy.  and chemotherapy. 

Genestra BrandsGenestra Brands

HMF Replete new and improved formula! HMF Replete new and improved formula! Each sachet (20 g) of HMF Replete supplies: Each sachet (20 g) of HMF Replete supplies: Lactobacillus acidophilus .........75 billion CFULactobacillus acidophilus .........75 billion CFU Bifidobacterium Bifidum .......12.5 billion CFU Bifidobacterium Bifidum .......12.5 billion CFU Bifidobacterium lactis ........... 12.5 billion CFU Bifidobacterium lactis ........... 12.5 billion CFU Lactobacillus salivarius ........... 30 billion CFU Lactobacillus salivarius ........... 30 billion CFU Fructo-oligosaccharides .................... 10 gFructo-oligosaccharides .................... 10 g May contain up to .................. 170 billion CFU May contain up to .................. 170 billion CFU

HMF RecommendationsHMF Recommendations

Intensive PhaseIntensive Phase

Take 1 packet daily (½ packet Take 1 packet daily (½ packet twice daily) after meals, mixed in twice daily) after meals, mixed in water or off the spoon for 7-14 water or off the spoon for 7-14 days. days.

Clinical Considerations Clinical Considerations

During and Post-antibiotic therapy During and Post-antibiotic therapy Acute intestinal upset Acute intestinal upset Candidiasis Candidiasis Digestive disturbances (bloating, Digestive disturbances (bloating,

gas) gas) Parasitic infections Parasitic infections Chronic Fatigue Syndrome Chronic Fatigue Syndrome Bowel problems (constipation, Bowel problems (constipation,

diarrhea, IBS) diarrhea, IBS)

Intermediate PhaseIntermediate Phase

Take ½ packet daily after meals Take ½ packet daily after meals mixed in water or off the spoon. mixed in water or off the spoon.

Clinical Considerations Clinical Considerations

General illness General illness Stressful life style Stressful life style Parasitic infections Parasitic infections Digestive problems (bloating, gas) Digestive problems (bloating, gas) Constipation Constipation Excessive alcohol consumption Excessive alcohol consumption Bowel problems (constipation, Bowel problems (constipation,

diarrhea, IBS) diarrhea, IBS) Chronic Fatigue Syndrome Chronic Fatigue Syndrome Candidiasis Candidiasis

Genestra BrandsGenestra Brands

HMF Replete Features:HMF Replete Features: HMF replete is the strongest HMF probiotic HMF replete is the strongest HMF probiotic prolonged stability allowing for storage up to 3 prolonged stability allowing for storage up to 3

months at room temperature months at room temperature resistant to stomach acidity and bile acids resistant to stomach acidity and bile acids scientific evidence with clinical data to confirm scientific evidence with clinical data to confirm

efficacy efficacy laboratory tested to confirm potency and purity laboratory tested to confirm potency and purity exceptional ability to attach to intestinal cells due exceptional ability to attach to intestinal cells due

to human sourced lactobacilli and bifidobacteria to human sourced lactobacilli and bifidobacteria

Genestra BrandsGenestra Brands Super Powder is a high-level Super Powder is a high-level

maintenance probiotic formula.maintenance probiotic formula.

Indicated for individuals who use Indicated for individuals who use antibiotics, oral contraceptives, steroids antibiotics, oral contraceptives, steroids and hormonal replacement therapy, and and hormonal replacement therapy, and for extreme fatigue, allergies, yeast for extreme fatigue, allergies, yeast overgrowth, stress, overgrowth, stress, hypercholesterolemia and indigestion. hypercholesterolemia and indigestion. 

HMF Super Powder is highly HMF Super Powder is highly recommended for ongoing maintenance recommended for ongoing maintenance in individuals who are immuno-in individuals who are immuno-compromised. compromised.

Ideal for children and adults who dislike Ideal for children and adults who dislike or have difficulty swallowing capsules.  or have difficulty swallowing capsules. 

* Powder is ideal for vegans* Powder is ideal for vegans

Genestra BrandsGenestra Brands

Each 1/4 teaspoon (1 gram) of HMF Super Each 1/4 teaspoon (1 gram) of HMF Super Powder supplies:Powder supplies:

Lactobacillus acidophilus (2 strains) ....... 6 billion Lactobacillus acidophilus (2 strains) ....... 6 billion CFU CFU

Bifidobacterium bifidum ......................... 1 billion Bifidobacterium bifidum ......................... 1 billion CFUCFU

Bifidobacterium lactis ............................. 1 billion Bifidobacterium lactis ............................. 1 billion CFUCFU

Fructo-oligosaccharides ................................ 800 Fructo-oligosaccharides ................................ 800 mg mg

May contain up to ................................. 12 billion May contain up to ................................. 12 billion CFUCFU

Intensive PhaseIntensive Phase Take ½ teaspoon twice daily after Take ½ teaspoon twice daily after meals for one month. Please note, meals for one month. Please note, for more severe intestinal upsets for more severe intestinal upsets you may safely take 1 Tablespoon you may safely take 1 Tablespoon twice daily.twice daily.

Clinical Considerations Clinical Considerations During and post-antibiotic use During and post-antibiotic use Acute intestinal upset (food Acute intestinal upset (food

poisoning, stomach ache) poisoning, stomach ache) Digestive disturbances (bloating, Digestive disturbances (bloating,

gas) gas) Candidiasis (yeast infections) Candidiasis (yeast infections) Bacterial Vaginosis Bacterial Vaginosis Parasitic infections Parasitic infections Chronic Fatigue Syndrome Chronic Fatigue Syndrome Bowel problems (constipation, Bowel problems (constipation,

diarrhea, IBS) diarrhea, IBS)

Intermediate PhaseIntermediate PhaseTake ¼ teaspoon one or twice Take ¼ teaspoon one or twice daily for one month. daily for one month.

Clinical Considerations Clinical Considerations General illness (cold, flu, mild General illness (cold, flu, mild

infection) infection) Stressful life style Stressful life style Parasitic infections Parasitic infections Digestive problems (bloating, gas) Digestive problems (bloating, gas) Constipation Constipation Excessive alcohol consumption Excessive alcohol consumption Bowel problems (constipation, Bowel problems (constipation,

diarrhea, IBS) diarrhea, IBS) Chronic Fatigue Syndrome Chronic Fatigue Syndrome Candidiasis Candidiasis

Genestra BrandsGenestra Brands

Each vegetable capsule Each vegetable capsule contains:contains:

Lactobacillus acidophilus (two Lactobacillus acidophilus (two human derived strains)....... 6 human derived strains)....... 6 billion CFU billion CFU

Bifidobacterium bifidum.......1 Bifidobacterium bifidum.......1 billion CFU billion CFU

Bifidobacterium lactis.......1 Bifidobacterium lactis.......1 billion CFU billion CFU

Fructo-oligo-saccharides Fructo-oligo-saccharides (FOS)(FOS)....... 200 mg ....... 200 mg

May contain up to.......12 May contain up to.......12 billion CFUbillion CFU

*All HMF probiotics are *All HMF probiotics are gluten and casein free.gluten and casein free.

Genestra Brands ~ Forte Genestra Brands ~ Forte Tx recommendationsTx recommendations

Intermediate PhaseIntermediate Phase Take 4 capsules daily (2 caps Take 4 capsules daily (2 caps twice daily after meals)twice daily after meals)

Clinical ConsiderationsClinical Considerations General illness General illness Stressful life style Stressful life style Parasitic infections Parasitic infections Digestive problems (bloating, Digestive problems (bloating,

gas) gas) Constipation Constipation Excessive alcohol Excessive alcohol

consumption consumption Bowel problems (diarrhea, Bowel problems (diarrhea,

IBS) IBS) Chronic Fatigue Syndrome Chronic Fatigue Syndrome Candidiasis Candidiasis

Maintenance PhaseMaintenance Phase1 or more capsules daily after 1 or more capsules daily after mealsmeals

Clinical ConsiderationsClinical Considerations Maintain Health of the Maintain Health of the

digestive system digestive system Prevention of colds and flu Prevention of colds and flu Stressful life style Stressful life style Digestive problems (bloating, Digestive problems (bloating,

gas) gas) Occasional Constipation Occasional Constipation Prevention of Candidiasis & Prevention of Candidiasis &

yeast infectionsyeast infections

Genestra BrandsGenestra BrandsHMF Natogen (previously Neogen)HMF Natogen (previously Neogen)

  Ingredients and Suggested Use Ingredients and Suggested Use

Each Scoop (100 mg) ContainsEach Scoop (100 mg) Contains

Lactobacillus acidophilus, guaranteed Lactobacillus acidophilus, guaranteed 1 billion CFU1 billion CFU

Lactobacillus casei Lactobacillus casei 1 billion CFU 1 billion CFU

Bifidobacterium infantis Bifidobacterium infantis May contain up to 4.5 billion CFU May contain up to 4.5 billion CFU

Lactose base (an important energy source for Lactose base (an important energy source for breast and bottle fed babies derived from milk breast and bottle fed babies derived from milk but free of casein)but free of casein)

Recommended DosageRecommended DosageInfants:Infants: Add one level scoop daily into the Add one level scoop daily into the feeding, or dip your baby finger into scoop and feeding, or dip your baby finger into scoop and give to infant to suckle on throughout the day.give to infant to suckle on throughout the day.

*All HMF probiotics are gluten and casein *All HMF probiotics are gluten and casein free.free.

Genestra price listGenestra price list

Probiotics & Prebiotics HMF______________________ 60 caps _ 10.50 HMF Forte _________________ 60 caps _ 15.00

HMF Forte ________________120 caps _ 27.50 HMF Neogen _________________ 6 g __ 10.50

HMF Powder_________________ 60 g __ 13.25 HMF Replete _______________ 7 sachets 17.25

HMF Super Powder ___________120 g __ 26.00 FOS + L-Glutamine___________ 60 caps _ 8.25

Genestra BrandsGenestra Brands

Seroyal, a Natural pharmaceutical company founded in 1984, Seroyal, a Natural pharmaceutical company founded in 1984, manufactures and distributes the extensive line of Genestra manufactures and distributes the extensive line of Genestra Brands nutritional and botanical products and is the North Brands nutritional and botanical products and is the North American distributor for the renowned Unda Homeopathic line. American distributor for the renowned Unda Homeopathic line. Ask your registered practitioner for more information. Ask your registered practitioner for more information.

Genestra Product GroupsGenestra Product Groups Amino AcidsAmino Acids & Proteins & Proteins

AntioxidantsAntioxidants & Oral Chelations & Oral Chelations Botanical CombinationsBotanical Combinations & Single Tinctures & Single Tinctures Calcium-Magnesium ComplexesCalcium-Magnesium Complexes DigestivesDigestives & Probiotics & Probiotics Essential Fatty AcidsEssential Fatty Acids & Phospholipids & Phospholipids FemaleFemale & Prenatal Formulas & Prenatal Formulas Homeopathic, EndocrineHomeopathic, Endocrine & Glandular Extracts & Glandular Extracts MineralsMinerals & Glucosamines & Glucosamines StandardizedStandardized & Phytonutrients & Phytonutrients Topical Care, Creams & Clinical AidsTopical Care, Creams & Clinical Aids Vitamin-Mineral ComplexesVitamin-Mineral Complexes Vitamins A, Vitamins A, C, C, E & E & B Complex<> B Complex<>

Genestra philosophy Genestra philosophy

Our products are based on scientific rationale using only the purest, highest quality, natural, raw Our products are based on scientific rationale using only the purest, highest quality, natural, raw ingredients available. We work closely with you and your peers to incorporate the latest research ingredients available. We work closely with you and your peers to incorporate the latest research and clinical findings into all our products.and clinical findings into all our products.

Seroyal’s products are made with care and attention to every detail. To ensure product uniformity, Seroyal’s products are made with care and attention to every detail. To ensure product uniformity, each ingredient is accurately weighed, tested and precisely mixed. To retain the full healing each ingredient is accurately weighed, tested and precisely mixed. To retain the full healing properties of each component, all tablets are cold-pressed and a low pressure compressing process properties of each component, all tablets are cold-pressed and a low pressure compressing process is used. This unique method does not involve the use of heat as is the standard practice in the is used. This unique method does not involve the use of heat as is the standard practice in the industry. No lubricants or fillers are used during our encapsulation process whenever possible. We industry. No lubricants or fillers are used during our encapsulation process whenever possible. We use the purest source of lubricant available, such as biodegradable vegetable cellulose, to maintain use the purest source of lubricant available, such as biodegradable vegetable cellulose, to maintain consistent capsule weight and content conformity. consistent capsule weight and content conformity.

Genestra’s vegetable capsules are free of pesticides, preservatives and additives, tested by Genestra’s vegetable capsules are free of pesticides, preservatives and additives, tested by government-approved independent laboratories to ensure quick dissolution and disintegration. We government-approved independent laboratories to ensure quick dissolution and disintegration. We guarantee that the disintegration time does not exceed 20 minutes from the time of ingestion for guarantee that the disintegration time does not exceed 20 minutes from the time of ingestion for capsules, and 30 minutes for all our tablets. We regularly test our capsules and tablets to confirm capsules, and 30 minutes for all our tablets. We regularly test our capsules and tablets to confirm weight variation and ingredient potency.weight variation and ingredient potency.

When manufacturing the Genestra products, we follow the procedures outlined in the Good When manufacturing the Genestra products, we follow the procedures outlined in the Good Manufacturing Practices. We ensure precision and objectivity during testing by contracting Manufacturing Practices. We ensure precision and objectivity during testing by contracting government-approved independent laboratories to assay and verify each ingredient for every government-approved independent laboratories to assay and verify each ingredient for every product in each lot. We reconfirm each ingredient’s potency, weight variation, disintegration time product in each lot. We reconfirm each ingredient’s potency, weight variation, disintegration time and the absence of heavy metals, bacteria, E. coli, salmonella, yeasts, mold and other and the absence of heavy metals, bacteria, E. coli, salmonella, yeasts, mold and other contaminants. contaminants.

About Genestra BrandsAbout Genestra Brands Are HMF products shipped with an ice pack?Are HMF products shipped with an ice pack?

No. But, after extensive product testing and new freeze drying technology performed by No. But, after extensive product testing and new freeze drying technology performed by Genestra, it was concluded that the ice pack did not make a difference during shipping since Genestra, it was concluded that the ice pack did not make a difference during shipping since the product potency was still well over 100% label claims when shipped with ice or no ice. the product potency was still well over 100% label claims when shipped with ice or no ice. The manufacturer states that it is no longer necessary to ship the HMF products with an ice The manufacturer states that it is no longer necessary to ship the HMF products with an ice pack for these reasons: pack for these reasons:

Genestra has added in 50% more probiotic than what the label guarantees per bottle. For Genestra has added in 50% more probiotic than what the label guarantees per bottle. For example, HMF Forte is guaranteed to have 6 billion L. acidophilus per serving, but there are example, HMF Forte is guaranteed to have 6 billion L. acidophilus per serving, but there are 12 billion present at time of manufacturing and it is kept frozen until shipping. 12 billion present at time of manufacturing and it is kept frozen until shipping.

October 2004:October 2004: The manufacturer has increased product stability again, allowing the The manufacturer has increased product stability again, allowing the probiotics to last up to 6 months at room temperature holding their GUARANTEED minimum probiotics to last up to 6 months at room temperature holding their GUARANTEED minimum potency on label! potency on label!

You will receive your HMF probiotic directly from the manufacturer in about 3-5 days. This You will receive your HMF probiotic directly from the manufacturer in about 3-5 days. This product is very fresh and has not been sitting around on our shelves. And, you are product is very fresh and has not been sitting around on our shelves. And, you are guaranteed it will contain 50% more than what the label states.guaranteed it will contain 50% more than what the label states.

How do I travel with my HMF probiotics?How do I travel with my HMF probiotics?We highly recommend you take your probiotics with you on all trips and vacations since their We highly recommend you take your probiotics with you on all trips and vacations since their potency will last for up to 6 months at room temperature un-refrigerated. But, when possible potency will last for up to 6 months at room temperature un-refrigerated. But, when possible and if convenient, we recommend you store your probiotics in the freezer or refrigerator, and if convenient, we recommend you store your probiotics in the freezer or refrigerator, especially if you plan to preserve freshness of your product for months or years. especially if you plan to preserve freshness of your product for months or years.

What is What is Clostridium DifficileClostridium Difficile ((C.difficileC.difficile)?)?

Clostridium difficile,Clostridium difficile, or or C. difficileC. difficile (a gram-positive anaerobic, SPORE forming (a gram-positive anaerobic, SPORE forming bacterium) bacterium)

Is now recognized as the major causative agent of colitis (inflammation of the colon) and diarrhea Is now recognized as the major causative agent of colitis (inflammation of the colon) and diarrhea that may occur following antibiotic intake. that may occur following antibiotic intake. C. difficile C. difficile infection represents one of the most common infection represents one of the most common hospital (nosocomial) infections around the world. Laboratory studies show that when hospital (nosocomial) infections around the world. Laboratory studies show that when C. difficileC. difficile colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to colonize the gut, they release two potent toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately cause diarrhea and certain receptors in the lining of the colon and ultimately cause diarrhea and inflammation of the large intestine, or colon (colitis).inflammation of the large intestine, or colon (colitis). This bacterium is primarily acquired in This bacterium is primarily acquired in hospitals and chronic care facilities following antibiotic therapy (symptoms may be delayed until 6-8 hospitals and chronic care facilities following antibiotic therapy (symptoms may be delayed until 6-8 weeks after antibiotic use). In addition to antibiotic use, chemotherapy and hospitalization, another weeks after antibiotic use). In addition to antibiotic use, chemotherapy and hospitalization, another risk factor for developing risk factor for developing C.difficileC.difficile diarrhea is simply advancing age. One study conducted in diarrhea is simply advancing age. One study conducted in Sweden found that individuals older than 60 years of age are 20 to 100 times more likely to haveSweden found that individuals older than 60 years of age are 20 to 100 times more likely to have C.difficileC.difficile in their stools compared to 10-20 year olds (Barlett, 2002). in their stools compared to 10-20 year olds (Barlett, 2002).

Symptoms of Symptoms of C.difficile?C.difficile?

Symptoms of Symptoms of C.difficileC.difficile diarrhea vary widely in severity. Some individuals experience recurrent mild- diarrhea vary widely in severity. Some individuals experience recurrent mild-to-moderate diarrhea, wither others suffer from recurrent bouts of severe abdominal and back to-moderate diarrhea, wither others suffer from recurrent bouts of severe abdominal and back cramping, frequent loose and watery, greenish, foul-smelling stools, flatulence, fever, as well as cramping, frequent loose and watery, greenish, foul-smelling stools, flatulence, fever, as well as variable amounts of mucus and blood in the stool. variable amounts of mucus and blood in the stool. C.difficileC.difficile diarrhea with accompanying diarrhea with accompanying inflammation of the colon can lead to toxic dilation of the colon, perforation of the colon, inflammation of the colon can lead to toxic dilation of the colon, perforation of the colon, dehydration, loss of water volume, shock, and death. dehydration, loss of water volume, shock, and death. The toxins produced by The toxins produced by C.difficileC.difficile can also can also trigger a whole host of extra-intestinal complications, including joint pain and sleep trigger a whole host of extra-intestinal complications, including joint pain and sleep disorders.disorders.

C.Difficile TxC.Difficile Tx

C.difficileC.difficile be treated effectively? be treated effectively?Although Although C. difficileC. difficile infection usually responds to antibiotic infection usually responds to antibiotic treatment with metronidazole or vancomycin, treatment with metronidazole or vancomycin, approximately 20 to 25% of patients will experience re-approximately 20 to 25% of patients will experience re-appearance of diarrhea and other symptoms weeks or even appearance of diarrhea and other symptoms weeks or even months after initial therapy has been discontinued. When months after initial therapy has been discontinued. When antibiotics are used to eradicateantibiotics are used to eradicate C.difficile, C.difficile, the antibiotics the antibiotics kill many of the “good” gastrointestinal flora species, but kill many of the “good” gastrointestinal flora species, but only kill non-spore forms of only kill non-spore forms of C.difficile.C.difficile. The The C.difficile C.difficile spores spores are still present. In order to eliminate are still present. In order to eliminate C.difficileC.difficile spores you spores you need to have some “good” normal flora present. need to have some “good” normal flora present. How can I How can I re-establish my gastrointestinal flora to eliminatere-establish my gastrointestinal flora to eliminate C.difficileC.difficile??Numerous of studies have proven certain probiotics to be a Numerous of studies have proven certain probiotics to be a successful solution for recurrentsuccessful solution for recurrent C.difficile C.difficile diarrhea. diarrhea.

Saccharomyces boulardiiSaccharomyces boulardii Saccharomyces boulardiiSaccharomyces boulardii

A non-disease causing yeast that survives A non-disease causing yeast that survives passage through the intestinal tract, passage through the intestinal tract, unaffected by antibiotics (although it will unaffected by antibiotics (although it will be killed by antifungal drugs). be killed by antifungal drugs).

Based on preliminary data indicating that Based on preliminary data indicating that this yeast could prevent antibiotic-this yeast could prevent antibiotic-associated diarrhea.associated diarrhea.

Numerous studies, have gone on to prove Numerous studies, have gone on to prove Saccharomyces boulardii, as an effective Saccharomyces boulardii, as an effective treatment for active treatment for active C.difficileC.difficile diarrhea. diarrhea.

Saccharomyces boulardiiSaccharomyces boulardii disrupts toxins disrupts toxins that would normally irritate the intestines,that would normally irritate the intestines,

In addition, In addition, Saccharomyces boulardiiSaccharomyces boulardii stimulates the intestinal immune system to stimulates the intestinal immune system to secrete secrete C.difficileC.difficile toxin A-specific antibodies toxin A-specific antibodies (IgA) in the gut (Qamar et al., 2001).(IgA) in the gut (Qamar et al., 2001).

* It is then eliminated after * It is then eliminated after supplementation is stopped. supplementation is stopped.

Allergy Research GroupAllergy Research Group

http://http://www.allergyresearchgroup.com/www.allergyresearchgroup.com/proddesc/category/microbal.htmproddesc/category/microbal.htm

Thorne Thorne Lactobacillus sporogenesLactobacillus sporogenes

Lactobacillus sporogenes represents a Lactobacillus sporogenes represents a breakthrough in Lactobacillus breakthrough in Lactobacillus supplementation supplementation

a safe, stable, effective, L(+)-lactic-a safe, stable, effective, L(+)-lactic-acid-producing organism. acid-producing organism.

Lactobacillus sporogenes binds Lactobacillus sporogenes binds cholesterol in the gut, and may inhibit cholesterol in the gut, and may inhibit the cholesterol-producing enzyme HMG the cholesterol-producing enzyme HMG CoA Reductase.CoA Reductase.

It requires no refrigeration or special It requires no refrigeration or special handling.handling.

ResourcesResources

http://www.rockwellnutrition.net/home.asp http://www.rockwellnutrition.net/home.asp

http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf Infection.pdf

Manufacture sitesManufacture sites

http://www.seroyal.com/seroyal/Navigation/ProductLinePublic/Genestra_Line.htmhttp://www.seroyal.com/seroyal/Navigation/ProductLinePublic/Genestra_Line.htm

http://www.allergyresearchgroup.com/proddesc/category/microbal.htmhttp://www.allergyresearchgroup.com/proddesc/category/microbal.htm

http://www.thorne.com/altmedrev/fulltext/micro.html http://www.thorne.com/altmedrev/fulltext/micro.html

Microbial Ecology and Dysbiosis in Human Medicine ~ Microbial Ecology and Dysbiosis in Human Medicine ~ Excellent ArticleExcellent Article

jefechi.com/jefechi.com/probioticsprobiotics