prevalence of infective endocarditis in streptococcal ... · journal club 31.08.2020 dr. med. a....
TRANSCRIPT
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Prevalence of Infective Endocarditis in Streptococcal Bloodstream Infections Is
Dependent on Streptococcal Species
Journal Club 31.08.2020Dr. med. A. Durovic
Klinik für Infektiologie und SpitalhygieneUniversitätsspital Basel
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STUDY DESIGN
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RETROSPECTIVE DATA ANALYSIS
2008 – 2017
DENMARK
CAPITAL REGION (serving 1,5 Mio people)
DATASET
3 DANISH NATIONAL REGISTRIES
LOCAL DEPARTEMENTS OF CLINICAL MICROBIOLOGY
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INCLUSION
PATIENTS / DATA
• BSI (-30d TO +14d)
• HOSPITALISATION >14d
BSI-CASE
• MIN. 1 POSITIVE BLOOD CULTURE BOTTLE (1 EPISODE = 14d)
• MONOINFECTION
• STREPTOCOCCUS SPECIES IDENTIFICATION AVAILABLE
INFECTIOUS ENDOCARDITIS
• ICD-10 CODESBSI = bloodstream infectionIE = infectious endocarditis
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1. STREPTOCOCCAL BSI
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• 0,5% OF ALL BSI ANALYSED
• 6506 EPISODES
(236 PATIENTS WITH >1 EPISODE)
HOSPITALISED PATIENTS WITH STREPTOCOCCAL BSI
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2. INFECTIVE ENDOCARDITIS
IN STREPTOCOCCAL BSI
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7.1 % INFECTIVE ENDOCARDITIS
VARIATION: 0 – 48 %
HIGHLY SPECIES DEPENDENT
ICD-10 CODE + STREPTOCOCCAL BSI
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RISK FOR IE
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STREPTOCOCCAL GROUP vs. SPECIES - RELEVANCE FOR IE?
- outdated ?
- still relevant?
- more relevant than ever?
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DISCUSSION
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- ONLY PATIENTS WITH “IE-DIAGNOSIS” INCLUDED
- IMPORTANT DATA MISSING:
- ECHOCARDIOGRAPHY
- MICROBIOLOGY
- CLINICAL DETAILS (TREATMENT, OUTCOME)
- PATIENTS WITH BSI WITHOUT IE
- RELEVANCE STREPTOCOCCAL GROUP / SPECIES FOR IE?
- SIGNIFICANCE OF 1 SINGLE POSITIVE BLOOD-CULTURE?
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