PRELAB 4

PHARMACEUTICS II

ByMohamad Naseef

Prelab. 4

Preparations:1) Peppermint water2) Ca lactate 3) Suspension ----- Mist alba

Problems: Conversions

Conversions

Equivalents of length1 M. 39.37 in.1 in. 2.54 cm.

Equivalents of volume1 ml. 16.23 m

1 m 0.06 ml.1 f ℨ 3.69 ml.1 f ℥ 29.57 ml1 pt. 473 ml

1 gal. (U.S.) 3785 ml Equivalents of Weight

1 g. 15.432 gr.1 k.g. 2.2 lb. (avoir)

1 gr. 0.065 g. or 65 mg.1 oz.(avoir) 28.35g.

1 ℥ 31.1 g.1 lb. (avoir) 454 g.1 lb. (apoth.) 373.2 g.

Other Equivalents1 oz. (avoir.) 437.5 gr.

1 ℥ 480 gr.1 gal. (U.S.) 128 f ℥1 f ℥ (water) 455 gr.

p.15

2) The dose of a drug is 1/10 gr. per kg. of body weight. How many milligrams should be given to a person weighing 154 lb.?

•1 kg 2.2 lb

?? 154 lb

Wt of the person =1x154/2.2 = 70 kg

•1/10 gr 1 kg ?? gr 70 kg

The dose for this person = 70 x 1/10 =7 gr.

•1 gr 65 mg7 gr ?? mg

the required dose = 65 x 7 = 455 mg

AROMATIC WATERS

Peppermint WaterRxPeppermint oil 0.2 mlTalc 1.5 gWater to 100 ml

The Peppermint Water[E.P.]

Uses:carminative and flavoured vehicle

PEPPERMINT WATER

Add Talc + 4 drops of oil and levigate

Add 70 ml water

Transfer to bottle

Rinse with 30 ml

Shake for 10 minLeave for 5 min

Filter on filter paper Transfer

to cup measure and adjust volume

RxPeppermint oil 0.2 mlTalc 1.5 gWater to 100 ml

The role of Talc:(1)Distributing agent expose oil to

solvent action of water due to large surface area.

(2) Filter aid adsorb excess oil.

CALCIUM LACTATERx

Calci Lactatis Recentis ƷiSyrup Auranti ƷiiiAqua ad ℥iiiFiat: MisturaSig: Cochlearia magna duo bis in die sumenda

Ca lactate

Orange syrup

Water

Ca lactate should be freshly prepared

?CaCO 3 + Lactic acid

Good solubility No sour milk odor SOLUTION

BY CHEMICAL REACTION

used as source of Ca for children

CALCIUM LACTATERx

Calci Lactatis Recentis ƷiSyrup Auranti ƷiiiAqua ad ℥iiiFiat: MisturaSig: Cochlearia magna duo bis in die sumenda

= 4 X 1 = 4 g= 3 X 4 = 12 ml= 3 X 30 = 90 ml

Calculation:

Ca lactate

Orange syrup

Water

2 X 90 100 308M.wt.

100 g?? ??

Lactic acid contains lactic acid 87.5% (w/w) + lactide (dimer of lactic acid)

87.5 g 100 g58.44

g

actual bottle

??

/

1.2

55.2 ml

2 lactic acid + CaCO3 = Ca lactate + CO2 + H2O

CALCIUM LACTATERx

Calci Lactatis Recentis ƷiSyrup Auranti ƷiiiAqua ad ℥iiiFiat: MisturaSig: Cochlearia magna duo bis in die sumenda

= 4 X 1 = 4 g= 3 X 4 = 12 ml= 3 X 30 = 90 ml

2 lactic acid + CaCO3 = Ca lactate + CO2 + H2OCalculation:

Ca lactate

Orange syrupWater

2 X 90 100 308M.wt.100 g?? ??

= 32.4 g = 4o g xss

CALCIUM LACTATERx

Calci Lactatis Recentis ƷiSyrup Auranti ƷiiiAqua ad ℥iiiFiat: MisturaSig: Cochlearia magna duo bis in die sumenda

= 4 X 1 = 4 g= 3 X 4 = 12 ml= 3 X 30 = 90 ml

Lactic acid:100 g Ca lactate 55.2 ml lactic acid 4 g xLactic acid = 4 X 55.2 / 100 = 2.2 ml

CaCO3: 100 g Ca lactate 40 g CaCO3

4 g x CaCO3 =40 X 4 / 100 = 1.6 g

100 g Ca lactate needs 40 g CaCO3 and 55.2 ml lactic acid

The Mixture One coffeecupful to be taken twice daily.

Calculation:

Ca lactate

Orange syrupWater

2 TABLESPOONFULS = 2 X 15 ml = 30 ml = One coffeecupful

b.d.s. = twice daily

Preparation:

In the flask:• 2.2 ml lactic acid• 1.6 g CaCO3

• 60 ml waterBoil for 15 minutes (3 precautions )

Filter on filter paperTransfer to cup

measure

coolAdd syrup auranti

Complete volume to 90 ml

CALCIUM LACTATE

Lactide on storage hydrolysis lactic acid which is of sour taste we must change all lactide to lactic acid then add CaCO3 Ca Lactate by: 1) Diluting lactic acid with water2) Boil for 15 min (heat break lactide to lactic acid).3) Add excess CaCO3 (convert any lactic acid from lactide hydrolysis to Ca lactate)

Storage effect (Commercial form have objectionable odor of sour milk:)1) Lactide (hydrolysis) lactic acid sour taste & bad odor.2) Solubility decrease.

Lactic acid contains lactic acid 87.5% (w/w) + lactide (dimer of lactic acid)

2 lactic acid + CaCO3 = Ca lactate + CO2 + H2O

SUSPENSIONS

Mist albaRxMagnesium sulphate 5 gLight magnesium carbonate 1 gPeppermint water to 15 mlFiat: Mist

Sig.: 15 ml o.m.

Factor = 4

X 420 g4 g60 ml

Mitte: iv doses

Preparation:

Grind MgSO4 in mortar

Add MgCO3 in mortar

Add peppermint water till pourable

Continue volume with peppermint water

Transfer to cup measure

RxMagnesium sulphate 5 gLight magnesium carbonate 1 gPeppermint water to 15 mlFiat: MistSig.: 15 ml o.m.

Use: Laxative and antacid in liver

cirrhosis

Rinse mortar with a LITTLE of peppermint water

The Mixture One tablespoonful to be taken every morning.

Shake The Bottle

TAKE CARE!!!!!!!!!!!!

Light magnesium carbonate is self- diffusable & suspending so, NO need for suspending agent