PinelLa Manie

FalretFolie circulaire

BaillargerFolie a double forme

BELGIUM

MANIC-DEPRESSIVE ILLNESS WAS10 per million new cases per year

100 new cases per year8 Times less common than Schizophrenia

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1985 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005

Articles on Mood Stabilizers

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Bipolar & Manic-Depressive Publications 1960-2007 Medline

EVIDENCE BASED MEDICINE

All studies of life expectancy on antipsychoticsShow a doubling of mortality ratesAnd a reduction of life expectancy

All studies of prophylaxis with mood stabilizersShow a doubling of suicidal act risk compared to placebo

Valproate and other mood stabilizers are among the most teratogenic drugs in medicine

1870 Weighing Scales1873 Anorexia Nervosa

1920sScales in Drugstores1920sIncrease in Eating Disorders

1960sBathroom Scales1960s Bulimia Nervosa

SuicideDivorceAlcoholismSubstance AbuseCareer Failure

1997Zyprexa MDL Documents

Zyprexa MDL Documents

Zyprexa MDL Documents

Zyprexa MDL Documents

BELGIUM

MANIC-DEPRESSIVE ILLNESS WAS10 per million new cases per year

100 new cases per year8 Times less common than Schizophrenia

BIPOLAR DISORDER IS5% + of Belgium400,000 Belgians

As common as Depression10 times commoner than Schizophrenia

THEODOREZIEHEN

Many of the mothers we interviewed remembered their baby’s excessive activity in utero.  

 1/ While my daughter was in the womb, she kicked so hard and often that I had very little rest… much of the time it felt like she was in a fight - rolling and tumbling around and then, when she was born.. she kept all the other babies up with her screaming. 2/ I too noticed signs that this was an extra-spirited child. In fact, while I was pregnant, I remember saying, “Uh-oh, the baby is angry again.” His kicks would last for an hour as I doubled over in pain..3/ “At 14 weeks the sonographer and obstetrician were unable to get a picture of Ian’s face and could not sample the amniotic fluid due to constant, unpredictable activity.”

EVIDENCE BASED MEDICINE

J American Academy of Child & Adolescent Psychiatry 42, 1494-1503

Car dans la Manie, comme dans beaucoup d’autres maladies, s’il y a un art de bien administrer les médicamentes, il y a un art encore plus grand de savoir quelquefois s’en passer.

Philippe Pinel 1800.

www.davidhealy.org

www.Rxisk.org

www.davidhealy.org

www.Rxisk.org

Dear Dr Healy,

Thank you very much for all your hard work on this article. I'm afraid we've run into a legal wall with our libel lawyer reluctant for us to publish your piece… I remain supportive of publication but obviously can't do this against legal advice.

Our lawyer has several questions that he wants us to address at this stage. He isn't ruling out publication, but we need to reassure him about the facts first.

Best wishes,

Editor BMJ

Bipolar disorder 5%

Under-acknowledged and under-researched

My doc and I decided not to have antidepressants

Identify triggers ….

My feelings of persecution are really …

In my most recent episode I used a mood scale ..

UNMET NEEDS

Zyprexa MDL Documents