S286 19th World Congress of Neurology, Poster Abstracts / Journal of the Neurological Sciences 285 S1 (2009) S155–S339

in Asia. However, the epidemiology of PD in Asian countries is

poorly understood. This review brings together evidence on the

prevalence and incidence of PD in Asian countries and identifies

gaps in our knowledge.

Method: A systematic search was conducted using MEDLINE and

EMBASE from 1965 to October 2008. The selection criteria were

defined a priori. The prevalence and incidence were standardized

to WHO World Standard Population 2000. Twenty-one original

studies were selected for the review. Two studies in which the

ethnic origin of participants were classified and contained Asian

populations were included for analysis.

Results: Excluding one study with questionably low prevalence

and incidence, the remaining reported standardized prevalence per

100,000 of all age group in door-to-door surveys ranged from 51.3

to 176.9. The prevalence in record-based studies ranged from 35.8

to 68.3 per 100,000. The standardized incidence rates were 8.7 per

100,000 person-years in a door-to-door survey and 6.7 to 8.3 per

100,000 person-years from the record-based surveys.

Conclusions: The prevalence of PD in Asian countries appears to

be lower than that of western countries, but there is not much

difference overall. It is difficult to compare the incidence because

of the small number of studies. Varying methodologies, different

diagnostic criteria, and case finding strategies contribute to the

variation in the reported prevalence and incidence of PD.

PO24-TH-02

Incidence and prevalence of Parkinson disease in Canadian

seniors

M. Wieler1, D.C. Voaklander2, C.A. Jones3, W.R.W. Martin1.1Neurology, University of Alberta, Edmonton, Canada; 2Public Health

Sciences, University of Alberta, Edmonton, Canada; 3Physical Therapy,

University of Alberta, Edmonton, Canada

Purpose: Reported incidence and prevalence rates for Parkinson

disease (PD) vary widely. To determine a more accurate estimate

of these rates for people 65 years and older, a combination of 3

different provincial administrative databases were analysed. These

data are part of the public healthcare system in the province of

British Columbia, Canada.

Methods: Record linkage of inpatient hospitalization and physician

billing records were examined for PD specific diagnostic codes.

PD drug prescriptions were captured through the provincial drug

insurance plan that provides 100% cost coverage for seniors. A

detailed algorithm based on hospitalisation, billing and drug use

(drug and dosage defined by a movement disorders neurologist)

was developed for case ascertainment from a base population of

450,000. Data for fiscal years from 1993–94 to 2000–2001 were

stratified by year, age group, sex and geographic location. Prevalence

rates were adjusted for deaths and migration.

Results: The majority of cases were identified from physician

records (73%), followed by hospitalisations (21%). Incidence rates

in 1993–94 were 398 per 100,000, falling to 320/100,000 in

1996–97, and then rising to 1999–00 of 450/100,000. Over eight

years, prevalence increased from 1571 to 2199/100,000 population.

Incidence and prevalence were related to increased age and male

gender. Incidence rates increased from age 65 to 95 but declined

after age 95. The male to female ratio of incidence ranged from 1.13

to 1.52.

Conclusions: PD is an ageing-related condition. Our incidence

and prevalence rates were higher than reported previously for

the Canadian population. This may be due, in part, to the use

of comprehensive, population-based administrative health data for

people 65 years and older residing in the community as well as in

institutions. The triangulation of overlapping and complementary

databases provides a comprehensive approach in maximising case

ascertainment.

PO24-TH-03

Incidence and prevalence of Parkinson disease in Moscow

E.I. Gusev, E.A. Katunina, Y.N. Bezdolniy. Russian State Medical

University, Moscow, Russian Federation

Aim: The aim of our research was to estimate clinical and epidemi-

ological indexes of Parkinson disease (PD) in Moscow population.

Materials and methods: The study was spent in neurological

department of regional clinic of northeast Moscow district from

01.07.06 till 31.06.08. The population of northeast Moscow district

is 1237899 people (12.4% from Moscow population). Organization

of neurological department work consists of information collection

about PD cases from 22 clinics of northeast Moscow district,

examination of patients for confirmation of PD and treatment. The

analysis of database was performed.

Results: 947 cases of PD were analyzed. Prevalence of PD was

76.5/100,000. Age analysis represented male domination in all age

groups with the greatest indexes older 70 years. General incidence

of PD was 7.63/100,000 a year. Incidence of PD was 9.85/100,000 for

female a year, 5.18/100,000 for male a year. The incidence among

female is more than male, but standardization of age structure

population revealed domination of male incidence at the age

of 60–69. The middle age of incidence of PD among male was

62.35±9.59, among female 64.12±9.81.

Conclusion: Cognitive disorders among patients with PDmade 64%:

34% from this sum–dementia. Light cognitive disorders were

marked in 30% cases, light and middle dementia in 31% cases. Hard

dementia was fixed in 3% cases. 71% of patients had depression

disorders. Light and middle depression were marked in 32% cases.

Strong and hard depression was revealed in 39% cases. There was

no correlation between prevalence of depression and length of

disease.

PO24-TH-04

Parkinson’s disease registry in Thailand launched

R. Bhidayasiri1, N. Wannachai1, S. Limpabandhu2,

T. Asawawichienchinda3, T. Poolpolamnuay2, L. Kaewwilai1,

R. Devahastin1, K. Phanthumchinda1. 1Chulalongkorn Comprehensive

Movement Disorders Center, Chulalongkorn University, Bangkok,

Thailand; 2Ministry of Public Health, Bangkok, Thailand; 3Division of

Epidemiology, Chulalongkorn University, Bangkok, Thailand

Background: Little is known about the epidemiology of PD in

Thailand. A nationwide PD registry in Thailand is established in

2008 to determine the number of PD patients (pts) in Thailand.

Objective: The initial goal is to generate a confidential database

containing basic information about individual PD patients in

various parts of Thailand. Chulalongkorn Comprehensive Movement

Disorders centre (www.chula-parkinsons.org) as a representation

of the Thai Red Cross society and the Ministry of Public Health of

Thailand implement this work.

Methods: Based on the interest expressed by disease advocates,

a means of PD patients who voluntarily register their own

information will be created. The collected information include

demographic information in the 7-item questionnaire. During

all stages of data collection, storage and use, strict confidential

procedures conforming to national regulations are followed.

Results: The project started in July 2008 and will last for two years.

We estimate the target of PD population to be 66,000 pts. As of

May 2009, a total of 16,829 (25.5%) pts voluntarily registered and

5,027 pts completed the 7-item questionnaire. There were 2570 M

and 2457 F. 2037 (40.5%) pts were above 70 years old and only

302 pts (6.2%) represents a young-onset PD. 3445 pts (68.5%)

had tremor as their initial symptom, followed by bradykinesia

(54.2%). 3157 (62.8%) reported bradykinesia as major troublesome

symptom. 39.3% of pts reported symptoms of motor fluctuations

with “wearing-off” symptom being the most common (94.3%). 4053

pts (80.6%) take levodopa while 25.7% and 21.5% of pts utilize

anticholinergics and dopamine agonist respectively. 68.5% of pts

denied history of smoking.