www.emka.fr Tel: +1 (877) 572-4737 +33 (0)1 40 60 76 00 +86 (0)10-85376382 +81 (0)50-5830-9882 (North America & Canada) (Europe & Middle East) (China) (Japan)

Whole Body PlethysmographPlethysmography for conscious unrestrained animals

MEASUREMENTS

» Respiratory rates & durations

» Flow & volume changes

» Quantifies the index of bronchoconstriction (penH)

FEATURES & BENEFITS

» For conscious and freely moving mice, rats and guinea pigs

» Larger plethysmographs on request (rabbit, ferret, dog, pig, primate)

» Non-invasive measurements for longitudinal studies

» No surgery - monitor the same animal day after day

» Long term monitoring of pulmonary function

» Ease of use: start an experiment on multiple animals in minutes

» Efficient screening

» Low noise pneumotachographs to reduce external artefacts

» Regulated ventilation for noise-free air renewal

Conscious & spontaneously breathing

Ease of use Efficient screening

SYSTEM CONFIGURATIONS & OPTIONS

» Temperature & humidity correction

» Acclimation tool

» Chamber for neonates

» Apnea & cough/sneeze detection

» Adapted plethysmograph for behavior & EEG studies in rats

» Possible combination with implanted telemetry for cardiorespiratory studies (ECG, blood pressure)

» Swivel/tether system, for simultaneous measurement of additional physiological parameters (BP, ECG, SPO2… ) or blood sampling following drug injections

» Controlled & automated aerosol delivery

» Controlled atmosphere (hyperoxia, hypoxia, hypercapnia)

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www.emka.fr Tel: +1 (877) 572-4737 +33 (0)1 40 60 76 00 +86 (0)10-85376382 +81 (0)50-5830-9882 (North America & Canada) (Europe & Middle East) (China) (Japan)

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Whole Body Plethysmograph

AEROSOL DELIVERY

nebulizationCONTROLLER is used in conjunction with the nebulization head (Aeroneb® Lab Nebulizer from Aerogen Inc) to generate a low-velocity fine-droplet aerosol.

» Each nebulizationCONTROLLER drives up to 4 nebulization heads

» Multiple nebulizationCONTROLLER can be linked to drive more than 4 nebulization heads

Adjustable aerosol generation rate (5 % to 100 % of the maximum quantity):

» Prevents cannulae obstruction or increase of particule sizes

Continuous nebulization or only during inspiration:

» Avoid aerosol accumulation inside tubing when the animal is not inspiring (especially useful for anesthetized mice)

Sequential or simultaneous delivery of aerosol in several plethysmographs

EXPOSURE TO GAS MIXTURE WITH MASS FLOW CONTROLLER

» Evaluate the effect of hypoxia, hyperoxia and hypercapnia.

» Up to 3 gases can be controlled (e.g O2 + N2 + CO2 or air + CO2)

» Full automation possible through iox2 protocols

DATA ACQUISITION & ANALYSIS

» iox software : Data recording, real-time analysis & display, synchronized video recording, nebulization remote control with large variety of nebulization protocols

» datanalyst software: Data post-processing

» GLP compliance : access control, audit-trail, electronic signature

Plethysmography for conscious unrestrained animals

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