Big (Biomedical) DataPanel discussion

• (Chair) Fiona Nielsen, CEO, DNAdigest and Repositive

• Adam Auton, Senior Statistical Geneticist, 23andMe

• Mathew Woodwark, Director of Research Bioinformatics, MedImmune

• Eric Little, VP Data Science, Osthus

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Big Biomedical Data – chair introduction

Pistoia Alliance European Conference 2016 210 May, 2016

• Fiona Nielsen, CEO of DNAdigest and

Repositive

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 310 May, 2016

• High throughput technologies – biology is

moving from the lab to the computer

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015

Genomes Sequenced

80+PB

Sequenced

every year

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Big Biomedical Data – intro

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• Growing interest and growing databanks

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 510 May, 2016

• Genomics, Proteomics, metabolomics, all the

omics!

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 610 May, 2016

• Challenges in all dimensions of big data:

Volume, Velocity, Variety, Veracity

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 710 May, 2016

Assay Types

Dedicated to…

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 810 May, 2016

1

10

100

1000

10000

100000

1000000

Sam

ple

# (

Log1

0)

Top 5:GEO (1.8M)PMI Cohort Program (1M)Auria Biopankki (1M)EGA (~0.6M)SRA (~0.5M)

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 910 May, 2016

Aboriginals

African Americans

Africans

Australians

Chinese

MalaysIndians

DanishDutch Estonian

Russian

European Ancestry

FinnishIcelandic

JapaneseKorean

Latin Americans

Saudi

Swedish

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Big Biomedical Data – intro

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9475600

88

660

26

68

5062

3

25

0

0

23

International

Interesting site to look at: http://omicsmaps.com/stats

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1110 May, 2016

• Challenges in all dimensions of big data: How to

collect? How to store? How to analyse?

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1210 May, 2016

• Challenges for international research

community: How to work across borders and

silos?

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1310 May, 2016

• Additional challenges for biomedical: Data

privacy, data governance, patient consent,

medical legislation

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1410 May, 2016

• How will the landscape change when genomics

moves to the clinic?

?

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1510 May, 2016

• Is Big Data a promise of Big Findings?

?

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1610 May, 2016

• Community-led databanks: patient groups,

academia, the general public

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Big Biomedical Data – intro

Pistoia Alliance European Conference 2016 1710 May, 2016

• For our panel discussion:

• How can Pistoia Alliance members uncover

value from Big Biomedical Data?

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Big (Biomedical) Data panel speakers:

Pistoia Alliance European Conference 2016 1810 May, 2016

Adam Auton

Senior Statistical Geneticist, 23andMe

Mathew Woodwark

Director of Research Bioinformatics,

MedImmune

Eric Little

VP Data Science, Osthus

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Thanks to our panel speakers:

Pistoia Alliance European Conference 2016 1910 May, 2016

Adam Auton

Senior Statistical Geneticist, 23andMe

Mathew Woodwark

Director of Research Bioinformatics,

MedImmune

Eric Little

VP Data Science, Osthus