Big (Biomedical) DataPanel discussion
• (Chair) Fiona Nielsen, CEO, DNAdigest and Repositive
• Adam Auton, Senior Statistical Geneticist, 23andMe
• Mathew Woodwark, Director of Research Bioinformatics, MedImmune
• Eric Little, VP Data Science, Osthus
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Big Biomedical Data – chair introduction
Pistoia Alliance European Conference 2016 210 May, 2016
• Fiona Nielsen, CEO of DNAdigest and
Repositive
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 310 May, 2016
• High throughput technologies – biology is
moving from the lab to the computer
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015
Genomes Sequenced
80+PB
Sequenced
every year
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 410 May, 2016
• Growing interest and growing databanks
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 510 May, 2016
• Genomics, Proteomics, metabolomics, all the
omics!
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 610 May, 2016
• Challenges in all dimensions of big data:
Volume, Velocity, Variety, Veracity
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 710 May, 2016
Assay Types
Dedicated to…
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 810 May, 2016
1
10
100
1000
10000
100000
1000000
Sam
ple
# (
Log1
0)
Top 5:GEO (1.8M)PMI Cohort Program (1M)Auria Biopankki (1M)EGA (~0.6M)SRA (~0.5M)
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 910 May, 2016
Aboriginals
African Americans
Africans
Australians
Chinese
MalaysIndians
DanishDutch Estonian
Russian
European Ancestry
FinnishIcelandic
JapaneseKorean
Latin Americans
Saudi
Swedish
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1010 May, 2016
9475600
88
660
26
68
5062
3
25
0
0
23
International
Interesting site to look at: http://omicsmaps.com/stats
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1110 May, 2016
• Challenges in all dimensions of big data: How to
collect? How to store? How to analyse?
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1210 May, 2016
• Challenges for international research
community: How to work across borders and
silos?
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1310 May, 2016
• Additional challenges for biomedical: Data
privacy, data governance, patient consent,
medical legislation
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1410 May, 2016
• How will the landscape change when genomics
moves to the clinic?
?
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1510 May, 2016
• Is Big Data a promise of Big Findings?
?
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1610 May, 2016
• Community-led databanks: patient groups,
academia, the general public
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Big Biomedical Data – intro
Pistoia Alliance European Conference 2016 1710 May, 2016
• For our panel discussion:
• How can Pistoia Alliance members uncover
value from Big Biomedical Data?
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Big (Biomedical) Data panel speakers:
Pistoia Alliance European Conference 2016 1810 May, 2016
Adam Auton
Senior Statistical Geneticist, 23andMe
Mathew Woodwark
Director of Research Bioinformatics,
MedImmune
Eric Little
VP Data Science, Osthus
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Thanks to our panel speakers:
Pistoia Alliance European Conference 2016 1910 May, 2016
Adam Auton
Senior Statistical Geneticist, 23andMe
Mathew Woodwark
Director of Research Bioinformatics,
MedImmune
Eric Little
VP Data Science, Osthus
