peter kjäll
TRANSCRIPT
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Peter Kjäll
Business Area Manager – Life Science Acreo Swedish ICT
BioCom LabBioelectronics and printed electronics for future eHealth
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How we work - Industry
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Technical Expertise
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Distributed diagnostics and eHealth solutions will increase
resources for the individual meeting
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1970 2016
2016
Functions: • Adaption • Safety systems • Emergency call • Remote Diagnostics • Remote service • Connectivity Conditions: • Regulatory • Reliability • Harsh environment
LET US COMPARE… with the dramatic development of the
automotiveFunctions: • Adaption • Safety systems • Emergency call • Remote Diagnostics • Remote service • Connectivity Conditions: • Regulatory • Reliability • Harsh environment
2030
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Printed Biosensor
BioCom Lab - Towards the intra body network
Sensors on /in the body
E-TreatmentCommunication
Sensors in the ambidient
Vision of a Smart intra-body network together with connection to the cloud or a doctor would make possible functions like remote diagnostics, remote emergency calls, remote therapy etc.
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BioCom Lab - A first venture - 4 M EUR
Smart system for prognosis, diagnostics and treatment of epilepsy
Epilepsy is the most common serious neurological condition, affecting almost 60 million people and 2.5 million new cases are each year.
Not possible to intervene with oral medication. Would benefit from very fast and on-demand treatment.
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BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy
Sensoring – EEG (ElectroEncephaloGraphy) and more
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BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy
Sensoring – Vital parameters, holistic approach
Pulse Blood pressure
Oxygen saturation
Respiratory rate
Temperature
Sweat
Electrolyte
Homeostasis
ECG
MovementMotoric functions
Balance
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BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy
Ionpump – E-treatment
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drug / neurotransmitter
electron
SUBSTANCE DELIVERY
e–
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BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy
Ionpump – E-treatmentLow Mg2+
4-AP
CA3
CA1
CA3 CA1
pumpon
pumpon
pumpon
pumpon
activity stopped
activity stopped
50 µV
50 ms
recording electrode
(CA3)
50 µV 1 min
50 µV 1 min
50 µV 20 s
10 µV 20
s
10 µV
100 ms
recording electrode
(CA1)
ion pump outlets
CONTROLLING EPILEPTIFORM ACTIVITY EX VIVO
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induced hypersensitivity
first organic electronic therapeutic
…in an awake animal
direct delivery to spinal nerves
low dose, no side effects
DELIVERY TO THE SPINAL CORD
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DELIVERY TO THE SPINAL CORD
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BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy
Communication InterfacesDatatransmission with the human body as conductor
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BioCom LabSmart system for prognosis, diagnostics and treatment of epilepsy
Big-Data Analysis
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Eco-system for Innovation
Research Prototype Development Commercialization
Industry
PEA Manufacturing
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PRINTED ELECTRONICS IS ALL ABOUT ……produce electronics in the same way as we produce newspaper so we can provide
• Packages with built in quality control, logistic trackers and tempearture sensors
• Simple disposable tests for home diagnostics • Smart cards with skimming control • Food containers with allergy warning
and much much more……
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PROPERTIES: • Electrochemically
and electrolyte gated OFET
• 0.5 – 3 V • Switch time:1E-6 to
1E-2 s
Transistors, resistors
PROPERTIES: • Hybrid material • Up to 2 GHz
Diodes Displays
TECHNOLOGY PLATFORM
PROPERTIES: • Monochrome • Emissive • Paper or plastic • 1-3 V (reflective)
PROPERTIES: Electrolyte based sensor capacitors or transistors. Piezo and Pyroelectrical
Analyte parameters: humidity,
heat ,pressure, vibrations, bio, etc
(www.3-plast.com)
Sensors
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• “Printed instrument” • Low cost • Disposable • Generic sensor
technology platform • Multiple sensors
Printed Sensors and Biosensors
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Point of Care • Glucose • Personalized medicine • Blood coagulation • Creatinine • Medication safety Printed Biosensors on band aid
• Temperature • EEG/ECG • Oxygen • Glucose • Inflammation • Active wound healing
Printed Biosensor
Formfactors Printed Sensors on Packages • Temperature • Time • Humidity • Security and Safety • Food Quality
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Home Care • Glucose • Fall detection • Blood coagulation • Medication safety • Pressure Long Term Care
• Pressure Ulcer • Venous Thromboembolism • Temperature / Fever • Humidity / Wetting • Inflammation • Active wound healing
Healthcare situationsAcute Care and Interactive implants • Temperature • Positioning • Wireless sensor patches • Wound Hemorrhage • Fiber optic Sensors
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Smart clothes for diagnosis and treatment
Problem Epilepsy and Parkinson are common chronic neurological diseases. Solution Comfortable, smart garments with built-in sensor systems for monitoring movements, heart rate etc
Goal To improve the diagnosis, treatment and quality of life for the patients. Already tested in Clinic by collaboration with Sahlgrenska Akademien.
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Temperature label for vaccines22 million children below the age of one not receiving their full dose of vaccinations each year.”
• “Currently, the requirement for a vaccine to be transported and stored in a constant cold chain, from the time it leaves the manufacturer until it is used at a vaccination point, places huge logistical challenges on vaccination providers who must ensure that the cold chain is maintained each step of the way. Although this is not a significant challenge in wealthy countries, it is a considerable obstacle in developing countries, particularly in areas that are hot, isolated, and which lack reliable electricity for refrigeration. This difficulty in getting vaccines to some places is a significant cause of low immunization rates in some countries, leading to more than22 million children below the age of one not receiving their full dose of vaccinations each year.”
An MSF staff member vaccinates a young patient in South Sudan
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Possible Effects• More accurate diagnosis • Early warning eg. heart
failure, stress, burnout, ... • Automatic, person specific
and situation based medication
• Patients can be mobile • Automatic control systems
(Parkinson, Epilepsy..) • etc…
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Inspiring environment and close collaboration
Develop your next innovation at BioCom Lab