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147
PERFORMA FOR THESIS
Data Collection
Particulars of patients:
Name…………………Age/Sex……………..Religion………………Occupation……
…
Religion…………………………
Address…………………………………
Presenting complaints:
Pain: Right knee/left knee/DIP / Wrist /Hip/Ankle
Body Height & Weight (in Kg) ……………………………………………………
Symptoms: Swelling/Warmth/Stiffness/Crepitus/Tenderness
Duration of Stiffness :> 30 min/<30 min/30 min
Severity: Mild/Moderate/Severe
Previous History
Illness: Yes/No Diagnosis ……………………
1 Case No. 5 Date of Admission
2 MRD No. 6 Date of Discharge
3 Hospital No. 7 Department
4 Bed No. 8 Unit (if any)
148
Accident that may account to trauma/infection/joint intervention/RA
Family history: Hereditary disorder: Yes/No
Social and Occupational history:
Nature of occupation…………………… Use of tobacco: Yes/No
Use of alcohol: Yes/No Diet: Rice/Chapatti
General appearance
Build: Slim/Average/Overweight/Obese
Body height …..ft…..inches Weight…..kg
Treatment history
Drugs : Yes/No Surgery: Yes/No
Oral contraceptives: Yes/No Arthroscopy: Yes/No
Others…….
Radiological impressions…………… Diagnosis……………………
149
CURRICULUM VITAE
1. NAME: Sonam Choden Bhutia
2. DATE OF BIRTH : 28th /02 /1980
3. EDUCATIONAL QUALIFICATION
Graduation Year
University : North Bengal University 2002
Specialization: B.Sc
Post Graduation Year
University : Sikkim Manipal University 2005
Specialization : Msc (medical biochemistry)
Doctor of Philosophy (PhD)
Institution : Sikkim Manipal Institute of Medical Sciences
Registration Date : 14th /8/2008
150
LIST OF PAPERS
PUBLISHED ON THE BASIS OF THIS THESIS
1. Sonam Choden Bhutia, Mingma Lhamu Sherpa, S.K.Dewan and T.A.Singh
(2015) (Accepted). Indian journal of Medical Research :IJMR_1235_14
2. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2014).
Production of polyclonal antibody against osteogenic protein-1 (OP-1): its role
as diagnostic tool in osteoarthritis. Singapore Medical Journal; 55(7):388-
391.
3. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2013)
Cartilage metabolic markers and antioxidant: its correlation in osteoarthritic
patients of Sikkim. Int J Cur Res Rev, 5(1): 58-63.
4. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2013)
Correlation of the Osteogenic Protein-1(OP-1) with age, cartilage metabolic
markers and antioxidants in the osteoarthritic patients of Sikkim. Journal of
Clinical and Diagnostic Research, 7(8): 1565-1567.
5. Sonam Choden Bhutia, T.A.Singh, Mingma Lhamu Sherpa. Diagnostic use of
polyclonal antibody against osteogenic protein-1(OP-1) in osteoarthritic
patients of Sikkim. ACBI Souvenir 40th
National conference of Association of
clinical biochemist of India (ACBICON), New Delhi. December, 2013.
151
PRESENTATIONS IN CONFERENCES
1. Diagnostic use of polyclonal antibody against osteogenic protein-
1(OP-1) in osteoarthritic patients of Sikkim. 40th
National conference
of Association of clinical biochemist of India (ACBICON), New Delhi.
December, 2013.
.
152
CURRICULUM VITAE
1. Name : Dr. T. Amumacha Singh
2. Date of birth : 1st /03/1953
3. Qualifications : i) CBSE : March 1968
ii) Bsc : April, 1971, Jabalpur University
iii) MBBS : June 1979, Guwhati University.
iv) MD : Ma/Ap 1992, Nagpur University
v) Post MD : Aug.1998, AIIMS, New Delhi.
vi) FIMSA : 1999, India
vii) FISBT : 2008, India
4 .Medical Registration no. : 8384, Assam Medical Council
5. Present Designation : Professor & Head, Department of Biochemistry &
Biotechnology, SMIMS.
6. Permanent address : Khurai Chinganbam Leikai, Tinsit Road, Imphal-
795010,Manipir, India
153
WORK EXPERIENCE
Professor SMIMS,Gangtok 1st/7/2006 Till date 08 years
Assoc.Professor -do- 13th/5/2002 31
st
/3/2006
4yrs,01 month
Asstt. Professor RIIMS, Imphal Feb.1994 April,2002 8 yrs,7months
Demonstrator -do- Jan,1981 Feb.1994 13 yrs,1 months
MD Guide RIIMS,Imphal &
SMIMS,Gangtok
1996 Till date 18 yrs
PhD Guide SMU,Gangtok 2008 Till date 6 yrs
PhD Examiner SMU,Gangtok 2004 Till date 10 yrs
Publications
1. T.A.Singh ; K Cheirmaraj; MV Reddy; R Narang; BC Harinath .Diagnostic use
of filarial antibody and antigen isolated from hydrocele fluid for human filariasis.
Indian journal of experimental biology. 1993, Volume: 31:1- 4.
2. M Maneesh, H Jayalekshmi, T Suma, S Chatterjee,
A Chakrabarti, and T A
Singh. Evidence for oxidative stress in osteoarthritis .Indian J Clin Biochem. Jan
2005; 20(1): 129–130.
3. Sonam Choden Bhutia, Mingma Lhamu Sherpa, S.K.Dewan and T.A.Singh
(2015) (Accepted). Indian journal of Medical Research :IJMR_1235_14
154
4. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2014).
Production of polyclonal antibody against osteogenic protein-1 (OP-1): its role as
diagnostic tool in osteoarthritis. Singapore Medical Journal; 55(7):388-391.
5. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2013) Cartilage
metabolic markers and antioxidant: its correlation in osteoarthritic patients of
Sikkim. Int J Cur Res Rev, 5(1): 58-63.
6. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2013)
Correlation of the Osteogenic Protein-1(OP-1) with age, cartilage metabolic
markers and antioxidants in the osteoarthritic patients of Sikkim. Journal of
Clinical and Diagnostic Research, 7(8): 1565-1567.
7. Dr Tshering Paljor , Prof T A Singh and Prof. Mingma Lhamu Sherpa
ACBICON Analysis of Gall stone among patienta attending State Referral
Hospital Sikkim. ACBI Souvenir.40th National conference of Association of
clinical biochemist of India (ACBICON), New Delhi. December, 2013.
8. Dr. Anne Deborah Rai, Prof T.A Singh and Prof Mingma Lhamu Sherpa.
Comparison of bone turnover marker in pre and post menopausal women with
osteopenia and osteoporosis in Sikkim. ACBI Souvenir 40th National
conference of Association of clinical biochemist of India (ACBICON), New
Delhi. December, 2013.
155
9. Sonam Choden Bhutia, T.A.Singh, Mingma Lhamu Sherpa. Diagnostic use of
polyclonal antibody against osteogenic protein-1(OP-1) in osteoarthritic patients
of Sikkim. ACBI Souvenir 40th
National conference of Association of clinical
biochemist of India (ACBICON), New Delhi. December, 2013.
10. B.Paul, T.A.Singh, P.K. Mitra.Effect of leaves of Cassia alata Linnaeus
(Sasesalpiniaceae) on the growth of Staphylococcus aureaus Rosenbach,Pleione
6(2):341-347.
11. B.Paul, T.A.Singh, P.K. Mitra.Effect of solvent,temperature and time on
extraction process of antimicrobial factor of Staphylococcus aureus present in
Cassia alat L,Bioscience Guardian,3(1),2103:206-211.
12. B.Paul. T.A.Singh, P.K. Mitra.Isolaltion and structural determination of an
antibacterial constituent from the leaves of Cassia alata Linn, Journal of
Pharnacology and Phytochemistry: 2(1),2013.
13. Sonam Choden Bhutia and T.A.Singh .Thyroid dysfunction in Sikkimese
populations-an acute health problem. ACBI SOUVENIR 35th
National
conference of Association of clinical biochemist of India (ACBICON).Kolkata.
December, 2008.
14. Dr.A Ghosh, Ms Y.Bhutia, Dr.T.A.Singh and Dr.M.L.Sherpa. Nitric oxide and
lipid profile in type II Diabetes mellitus-A case control study in East Sikkim,
Indian Journal of Clinical Biochemistry (suppl),2009/24:246.
156
CURRICULUM VITAE
Name : Dr. Mingma Lhamu Sherpa. MD, FIBST
Designation : Professor
Contact information : Department of Biochemistry, SMIMS, 5th
Mile,Tadong
Gangtok-737102, Sikkim, India
Email : [email protected]
Date of birth : 12th of December 1973.
Academic Background
DEGREE Year COLLEGE
MBBS 1998 Lady Hardinge Medical College, Delhi
M.D. (Biochemistry) 2004 Lady Hardinge Medical College, Delhi
WORK EXPERIENCE
JOB
DESCRIPTION
DURATION INSITUTE
Resident Intern
Jan 1998 to Dec 1998 Lady Hardinge Medical College,
Delhi
Junior Resident,
Department of Blood
Bank
Jan 1999 to Jun 1999 Lady Hardinge Medical College,
Delhi
Junior Resident, Jul1999 to Oct 1999 Lady Hardinge Medical College,
157
Department of Surgery Delhi
Junior Resident,
Biochemistry
July2001 to April 2004 Lady Hardinge Medical College,
Delhi
Assistant Professor,
Biochemistry
July 2004 till July 2009 Sikkim Manipal Institute of
Medical Sciences, Gangtok,
Sikkim, India
Associate Professor,
Biochemistry
July 2009 till July
2013
Sikkim Manipal Institute of
Medical Sciences, Gangtok,
Sikkim, India
Professor, Biochemisty May 2013 onwards Sikkim Manipal Institute of
Medical Sciences, Gangtok,
Sikkim, India
Awards and Honors:
1. Received the Mariamma Verghese Award, 1999 for the most compassionate house
surgeon at Lady Hardinge Medical College, New Delhi
2. Nominated for the Sita Devi Award for the Best Scientific paper 2006 at
ACBICON 2006 at Pune for the paper titled ‗Association of NO with c-FOS and c-
JUN in Breast Cancer‘
3. Fellow of International Society of Biotechnology, 2008
4. Received the Exemplary Performance Award- Programme Implementation
(Biochemistry) 2008 at the 8th Convocation, Sikkim Manipal University.
5. Fellow of Fogarty International Center, USA-2013-2014
MEMBERSHIP OF NATIONAL AND INTERNATIONAL BODIES:
1. Life Member of Association of Clinical Biochemists of India
2. Life Member of International Society of Biotechnology, India
158
3. Member of Institutional Ethics Committee, SMIMS, Gangtok, Sikkim, India 2012
onwards
4. Member of American Psychopathological Association, New York, 2013-2014
5. Reviewer for Addiction 2014
6. Reviewer for International Journal of Medicine and Public Health 2014
7. Unit Head , UNESCO Bioethics Chair, Sikkim, India
Training:
1. Organizing member of CME on ‗‘Molecular Medicine‘‘ in Lady Hardinge
Medical College, New Delhi,2003
2. Regional Workshop on ‗‘ Telemedicine & E-Healthcare Service Delivery‘‘,
Sikkim Manipal University.
3. Workshop on ‗‘Teaching learning‘‘ India, Sikkim Manipal University, 2006.
4. Member and Delegate of the ‗‘ Regional workshop on RNTCP-WHO‘‘,
October ,SMU,India,2006.
5. Workshop on ‗‘Scientific writing‘‘ SMIMS,Nov,2006
6. Participated in the CME ‗‘Postgraduate Curriculum in the
Millenium‘‘,SMU,Nov,2006
7. Workshop on ‗‘Laboratory Management‘‘ in AFMC Pune, Nov,2006.
8. Workshop on ‗‘Clinical skills and OSCE‘‘May 2008,Sikkim,India
9. Organizing member and Delegate in CME‘‘Awesome
Pulmonlogy‘‘May,2008
10. Delegate in update on‘‘Respiratory diseases in children‘‘, May 2008
159
11. Resource person,CME on Tuberculosis by State Task Force, Sikkim ,June
2008
12. Organising member in CEZIPS-East,Gangtok,2009.
13. Participated in the ‗‘Update on Respiratory diseases in children‘‘ held in
SMIMS,June 2011
14. A member of organizing committee for ‗‘24th annual conference if All India
Rhinology Society-Rhinocon-2011‘‘,SMU,April 2011
15.Attended the ‗‘ Hands on workshop on Mesenchymal stem cells held at Manipal
Institute of Regenerative medicine, Bangalore,July 4th -9
th, 2011.
16. The fogarty international centre INDO-US program in Non-communicable
Diseases (CNCD‖S ) Workshops on Research Skills building on 14th and 15
th of May
2013.
17. CME on stem cell , 20th June 2013 conducted by Dept of Biochemistry, SMIMS
18.Organizing member for the annual convocations for graduates of SMU.
19. Coordiantor of BScMLT course,SMU.
PUBLICATIONS
2002
1.Jain A,Mangal A,Sherpa M.L, Gayatri R and Goyal U .Placental ALP in serum and
placenta in pregnancy in Preganancy Induced Hypertension SOUVENIR,9th Asia
Pacific Congress of Clinical Biochemists and 28th annual conference of ACBI,2002.
160
2003
2.Battacharjee J and Sherpa M L.Role of Nitric oxide as endogenous scavenger of
lipid peroxidation trends in clinal Biochemistry and Laboratory medicine,2003.
3. Battacharjee J and Sherpa M L.Nitrix oxide and Transcription factor API in Breast
Cancer,ACBI Souvenir,29th annual conference of Association of clinical
Biochemistry of India,Jaipur,2003.
2006
4.Sherpa ML,Bhattacharjee J,Ravi B,Prusty BK and Das BC.Association o fNO with
c-FOS and c-JUN in breast cancer,ACBI Souvenir,33rd
annual conference of
Association of clinical biochemisty of India,Pune,2006.
2008
5.Mingma Lhamu Sherpa,Jayashree Bhattacharjee ,BINa Ravi,Bhudev C Das.NITRIC
OXIDE,MDA LEVEL SIN SERUM AND GPX ACTIVITY IN WHOLE BLOOD
BREAST CANCER PATIENTS.Indian Journal of Clinical Biochemistry;Dec
2008,vol.23(suppl).
2009
6.Mingma L Sherpa,‘‘Seasonal Affective Disorder‘‘,CEZIPS-East Zone
Souvenir,Gangtok,2009.
7. Dr.A Ghosh, Ms Y.Bhutia,Dr.T.A.Singh and Dr.M.L.Sherpa. Nitric oxide and lipid
profile in type II Diabetes mellitus-A case control study in East Sikkim,Indian Journal
of Clinical Biochemistry(suppl),2009/24:246.
2013
161
8. Dr Tshering Paljor, Prof T A Singh and Prof Mingma Lamu Sherpa ACBICON
Analysis of Gall stone among patienta attending State Referral Hospital Sikkim.
ACBI Souvenir. 40th National conference of Association of clinical biochemist of
India (ACBICON), New Delhi. December, 2013.
9. Dr. Anne Deborah Rai, Prof T.A Singh and Prof Mingma Lamu Sherpa.
Comparison of bone turnover marker in pre and post menopausal women with
osteopenia and osteoporosis in Sikkim. ACBI Souvenir 40th National conference of
Association of clinical biochemist of India (ACBICON), New Delhi. December,
2013.
10. Sonam Choden Bhutia, T.A.Singh, Mingma Lhamu Sherpa. Diagnostic use of
polyclonal antibody against osteogenic protein-1(OP-1) in osteoarthritic patients of
Sikkim. ACBI Souvenir 40th
National conference of Association of clinical biochemist
of India (ACBICON), New Delhi. December, 2013.
11. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa. Production of
polyclonal antibody against osteogenic protein-1 (OP-1): its role as diagnostic tool in
osteoarthritis. Singapore Medical Journal (accepted), SMJ-2012-623R1.
12. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2012) Cartilage
metabolic markers and antioxidant: its correlation in osteoarthritic patients of Sikkim.
Int J Cur Res Rev, 5(1): 58-63.
162
13. Sonam Choden Bhutia, T.A.Singh and Mingma Lhamu Sherpa (2013)
Correlation of the Osteogenic Protein-1(OP-1) with age, cartilage metabolic markers
and antioxidants in the osteoarthritic patients of Sikkim. Journal of Clinical and
Diagnostic Research, 7(8): 1565-1567.
2014
Bhutia SC, Singh TA, Sherpa ML. Production of a polyclonal antibody against
osteogenic protein-1, and its role in the diagnosis of osteoarthritis. Singapore Med J
2014; 55(7): 388-391.
Khandelwal B, Khatri D, Patnaik SK, Sherpa ML, Kar S. Microalbuminuria as an
overrated indicator of target organ damage in hypertension: a hospital based cross
sectional study. Int J Res Med Sci. 2014; 2(3): 881-885 doi: 10.5455/2320-
6012.ijrms20140822
Bhutia SC, Singh TA, Sherpa ML.Correlation of cartilage metabolic markers &
antioxidants with the severity of knee OA & its demographic characteristics.(
Accepted for publication by IJMR_1235_14).
PAPER/ POSTER PRESENTATION AT NATIONAL AND INTERNATIONAL
CONFERENCES
1. Placental ALP in Serum and Placenta in Pregnancy Induced Hypertension 9th Asia
Pacific Congress Clinical Biochemistry & 28th Annual Conference of Association of
Clinical Biochemist of India, 2002
2. Nitric Oxide and Transcription factor in AP1 of Breast Cancer 29TH Annual
Conference Of Association of Clinical Biochemist of India, Jaipur, 2003
3. Association of NO with c-FOS and c-JUN in Breast Cancer, Sita Devi Award
Session. 33RD Annual Conference of Association of Clinical Biochemist Of India,
Pune, 2006
163
4. Current Status – Biochemical Diagnosis of Human Tuberculosis. CME on
Tuberculosis by State Task Force, Sikkim, June 2008
5. Nitric Oxide, MDA levels in Serum and GPx Activity in Whole Blood of Breast
Cancer patients. 35th Annual Conference of Association of Clinical Biochemist Of
India, Kolkata, 2008
6. Attended CEZIPS, Sikkim 2009
7.Screening and laboratory diagnosis of Diabetes Mellitus , Training on NCD and
Mental Health for Medical Officers Department of Health and Human Services and
Family Welfare Department. Government of Sikkim, 17th August 2011, CRH,
Gangtok.
8. Evaluation of non enzymatic antioxidants and electrolyte status in hypertensive
patients, attending Central Referral Hospital, Gangtok. Cardiovascular Symposia.
39th Annual Conference of Association of Clinical Biochemist of India. Ranchi, 2012
9. Attended ―10th Anniversary BRAIN Disorders in the Developing world
Symposium, Bethesda, Maryland, DC‖ 11-13 Feb 2014
10. Sherpa ML, Lasopa SO, Vaddiparti K, Striley CW and Cottler LB. Does the age
of child affect drinking or depression status in the mother? Poster presented at the
103rd Annual Meeting of the American Psychopathological Association (APPA),
New York, March 3-5, 2014
11. Lasopa SO, Cottler LB, Sherpa ML and Acheampong A. Characteristics of heavy
drinking women: A community based study. Poster presentation at Research Day at
the College on Public Health and Health Professions at the University of Florida in
April 2014.
164
Experience in Educational, Research, Administration & Management
1. Member of the Cultural Committee SMIMS, 2006-2007
2. Supervisor and co-supervisor for dissertations of MSc Medical Biochemistry
3. Supervisor and co-supervisor for dissertations of MD students,
4. Co-supervisor for dissertations of DNB (Medicine) students
5. Supervisor and co-supervisor for dissertations of PhD students
6. Organizing Member for the Annual Convocations for graduates of Sikkim Manipal
University since 2008
7. Organizing member in various conferences and workshops held at SMIMS and
SMU
8. Appointed Member of SMIMS Institutional Ethics Committee in 2012.
9. NABL ASSESSOR IN MAY 2013
10. Course co-ordinator of BScMLT course, SMIMS since 2009
11. Pre Clinical ( MBBS) co-ordinator since 2013
12. Organised guest lecture on Regenerative Medicine June 2013
13. Conducted a ―Hands on Workshop on good practices of Phlebotomy by vacutainer
system‖. Trained doctors, nurses, students and technicians. June 2013
14. Attended the seminar on Bioethics at CMC Vellore, Nov 2014
15. Attended the Conclave on Asia Pacific Network of Bioethics , SRM, Chennai,
2014
Continued Medical Education (CME), Workshops and Trainings attended
1. Participated in Workshop on Youth and Promotion of Mental Health organized by
the Vishwa Yuwak Kendra Nov, 1996
165
2. Organizing member of CME on Molecular Medicine in Lady Hardinge Medical
College, New Delhi, 2003
3. Attended Regional Workshop on Telemedicine & E- Healthcare Service Delivery
SMU 2005
4. Participated as organizing member in the Regional Workshop on RNTCP- WHO,
October, SMU, 2006
5. Participated in the workshop on Scientific Writing, November, 2006
6. Participated in the workshop on ―Neonatal Advanced life Support‖ in SMU, April
2007
7. Participated in the workshop ―Pediatric Advances life Support‖ in SMU, May 2007
8. Participated in the CME- Emerging and Re-emerging infectious Diseases in India ,
SMU, 2008
9. Resource person, CME on Tuberculosis by State Task Force, Sikkim, June 2008
10. International Society of Biotechnology conference, as organizing Member. 2008
11. Organizing member of 35th Annual Conference of Indian Psychiatric Society,
Eastern Zonal Branch. (CEZIPS-2009) ―Theme: Substance abuse & Suicide‖ SMIMS
Gangtok, Sikkim.
12. Hands on workshop on Mesenchymal Stem Cells (MIRM-2011) Bangalore
13. Participated in the ―Update on Respiratory Diseases in Children‖ held in SMIMS ,
June 2011
14. Resource person for training on NCD and Mental Health for Medical Officers
Department of Health and Human Services and Family Welfare Department.
Government of Sikkim, 2011
15. ICMR: Sensitization workshop on Research Methodology: at SMU, 16-17th
October 2012
16. Attended and qualified the NABL Assessor Training course at CIPET,
Bhubaneshwar, March, 2013
166
17. Fogarty International Center, National Institutes of Health, USA, Indo-US
Training Program on Chronic Non-Communicable Diseases skills building workshop
on grant writing May, 2013
18. BD FACS Orient (BD Accuri C6) A course in Flow Cytometry Basics, August 2013,
BD-JH FACS Academy, New Delhi
19. NABL Assessors Orientation and Awareness Program (ISO15189: 2012) course at
Kolkata, August, 2013
20. Fogarty Post Doctoral Fellowship-Nov 2013-May 2014 , University of Florida,
Gainesville, Florida, USA
21. Basic Course Workshop in Medical Education Technologies, August, SMIMS,
Gangtok, 2014
22. Intellectual Property Rights protection Workshop, Gangtok, Sikkim, November 2014
167
DOCTORAL COMMITTEE
I. Air Marshal (Retd) Dr. G.S. Joneja, Dean, Administration Chairperson.
II. Dr. T.S.K.Singh , Professor & Head Microbiology, Member Secretary.
III. Dr.Selvam Ramachandran PT Associate Professor Physiotherapy, Asst.
Member Secretary.
IV. Dr. Bidita Khandelwal Professor & Head, Medicine, Member.
V. Prof. Mridula Das,Professor & Principal, SMCoN, Member.
VI. Dr. Sudip DuttaProfessor & Head, Pediatrics, Member.
VII. Dr. Sanjiba Dutta Professor & Head, Psychiatry, Member.
VIII. Dr. Luna AdhikariProfessor, Microbiology, Member.
IX. Dr. Nikita Joshi P Physiotherapy, Member.
Departmental Research Committee
X. Dr. T.A.Singh, Professor & Head, Biochemistry department.
XI. Dr.Mingma Lhamu Sherpa, Professor,Biochemistry department.
XII. Dr.S.K.Dewan,Associate Professor,Orthopedic department.
XIII. Dr.Sanjeev Dhakal,Associate Professor,Biochemistry department.
XIV. Dr.Sameer Bhandari,Associate Professor, Biochemistry department.