Pathology of the

gastrointestinal tract II

(liver, pancreas).

X. practical training

3rd year Dentistry

Congestion of the liver

Congestion of the liver

Congestion of the liver (hepar moschatum)

1 Portobilial spaces

2 Ways of congestion (congestion with

necrosis of hepatocytes)

Pseudolobulus from residues of 3 lobuli, in

centre is portobilium

1

1

1

2

2

Congestion of the liver (hepar moschatum), detail

1

3

2

3

1 Portobilium- dilatated branch of v. portae

2 Pseudolobulus from residues of 3 lobuli, in centre is

portobilium

3 Ways of congestion (congestion with necrosis of

hepatocytes)

4 Biliary duct

5 Branch of a. hepatica

4

5

Liver steatosis

Viral hepatitis

HAV RNA hepatovirus

HBV DNA hepadnavirus

HDV RNA defektní virus

non A non B (NANB)

HCV RNA flavi a pestivirus-like

HEV RNA kalicivirus

HFV RNA togavirus

HGV RNA flavivirus

others: herpesvirus, cytomegalovirus, paramyxovirus, ...

Acute stage of

viral hepatitis

Viral hepatitis

subacute fatal

Chronic viral

hepatis

Liver – chronic viral hepatis

1

2

3 1 Portobiliar space with chronic inflammatory infiltrate

2 „piece-meal necroses“

3 Central part of lobulus with mixed steatosis

Liver – chronic viral hepatis

1

2

1 Chronic inflammatory

infiltrate in portobiliar space

2 Biliary duct

Cirrhosis of the liver

etiology morphology

alcohol 60-70% mikronodular

CAH 10% makronodular

kryptogenic 10-15% mixed

biliáry primary

secondary

pigment haemochromatosis primary

secondary

Congenital metabolic disorders (tyrosinemia,galaktosemia ...)

Cirrhosis of the liver

Cirrhosis of the liver

Cavernous haemangioma – liver

kopie

Primary liver

carcinoma

Hepatocellular carcinoma

Hepatocellular carcinoma

Hepatocellular carcinoma

Cholangiocarcinoma of the liver

Acute haemorrhagic necrosis of pancreas

Cystic fibrosis of the pancreas

Cystic fibrosis of the pancreas