parkinson’s & a plant based diet
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Parkinson’s & a plant based diet . Danielle Selden Alicia Armeli. Proof in plants . Higher Quality of life . A concerning underlying problem with our current method of treatment- its not working long term . - PowerPoint PPT PresentationTRANSCRIPT
Parkinson’s & a plant based diet Danielle Selden Alicia Armeli
Why we chose this article....
Proof in plants • A concerning underlying problem
with our current method of treatment- its not working long term.
• Two recent studies have shown that a plant-based dietary pattern may protect against PD.
• This peer-reviewed article looks at the effectiveness of a plant-food diet in the management of PD.
Higher Quality of life
Currently there is no cure....
Quick Facts about Parkinson’s Disease (PD): • PD is a chronic progressive movement disorder in which the
neurons that produce dopamine are impaired.
• PD is characterized by slow and decreased movement, muscular rigidly, resting tremor, postural instability, and decreased dopamine transmission to the basal ganglia. Since Dopamine is not available movements can not be controlled.
• Etiology is unclear but is thought to arise from both genetic and environmental factors.
• Treatment includes medication, surgery, and other modalities to manage symptoms.
Introduction
• Preventing a high protein based diet is critical for treatment.
• Levodopa, a prodrug of dopamine (derived from the A.A tyrosine), remains the most effective treatment to alleviate motor dysfunction in PD.
• “The Protein Redistribution Diet” was formulated to avoid
the risk of nutritional deficiencies linked to extreme restriction in total protein intake.
• This intervention consists of a normoproteic diet- a pt’s main protein intake occurs in the evening meal in order to limit the negative interaction of LNAA on L-Dopa’s response at daytime, while the negative effects act up during sleep at night.
Why a plant-food diet?
• A plant-food vegan diet (PFD) is expected to raise L-Dopa availability and bring some advantage in the management of disease.
• This pilot study was designed to establish whether a PFD normoproteic protein redistribution diet can be just as effective as a protein-redistributed OD in improving motor performance in L-Dopa treated PD patients in the short term.
Subjects All 25 participants in the study were PD patients
• 12 were in the intervention group (PDi) and 13 in the control group (PDc), respectively.
• Pt’s have had a good response to levodopa in the past, with a daily dose over 350mg, under 850mg, and over 50 years of age, BMI over 18.5 and under 30.
• Pt’s were already following advices to limit total animal protein and to concentrate them in an evening meal in the context of an OD.
• Pt’s were given the choice to consume the PFD or the usual OD for a 4-week period.
Methods and Measures
• A quasi-experimental non-equivalent group design (NEGD) was utilized.
• The PD intervention (PDi) diet/vegan diet- includes plant-protein rich sources only for dinner (2/3 of total daily intake of PRO)
• The control group (PDc)/omnivorous diet- limited total animal food and concentrated them in the evening meal
• Neurological assessments were made by an experienced neurologist using the comprehensive PD measurement tool United Parkinson’s Disease rating system • Mann-Whitney • Sun Score• Hoehn and Yahr
Results
• After 4 weeks the PDi group showed a significant
reduction with respect to the PDc group in...
• Metabolic changes in the PDi group- total cholesterol, HDL cholesterol, apo-A1, and apo-B showed significant differences after 4 weeks.
PDi PDc(Mann-Whitney Test) UPDRS Total Score [P=0.008]
47.67 74.46
Sub-score III-Motor Performance [P=0.001]
25.42 46.46
Modified HY Scale [P=0.005]
1.96 3.15
Limitations
• Lack of random assignment of subjects to intervention or control groups.
• Both groups have small sample sizes.
• Short study time- 4 weeks.
• Lack of blood measurements of levodopa and dietary LNAA at the enrolment and after 4 weeks.
Conclusions
• This study showed after 4 weeks of a PFD in the PDi had a value 27 points (47.67 vs. 74.46) lower than the PDc group, a result that is clinically relevant.
• Due to its high fiber content, a PFD can potentially raise levodopa bioavailability by reducing the phenomenon of constipation.
• Consumption of a PFD is may be more effective than an OD for improving motor performances in PD pts.
• Additional studies need to be performed, especially longitudinal randomized trails of larger groups
A comprehensive plan for PD Patients
• Increase Antioxidants/ phytochemicals and mitochondrial stabilizers:• CoQ10 and Vitamin E • Vitamin D and Omega 3’s • Magnesium • Alpha lipoic acid
• Fava Beans- 3oz. Contain levodopa• Vegan diet • Acupuncture- shows reduced sxs• Massage- anecdotal evidence of reduced sxs
References Baroni L, Bonetto C, Tessan F, Goldin D, Cenci L, Magnanini P, Zuliani. Pilot dietary study with normoproteic protein-redistributed plant-food diet and motor performance in patients with Parkinson’s disease. Nutritional Neuroscience. 2011;14:1:1-9.
Mahan K L, Escott-Stump S, Raymond J L. Krause’s Food and the Nutrition Care. St. Louis, MO: Elsevier Saunders; 2012: 675-708. Parkinson’s Disease Foundation. Available at: http://www.pdf.org. Accessed May 30, 2012.
The Parkinson’s Foundation. Available at http://www.parkinson.org. Accessed May 31, 2012.
The Natural Standard. Parkinson’s Disease. Available at http://www.naturalstandard.com. Accessed May 30, 2012.