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Neuropathic Pain: Pharmacotherapy Treatment Outcome: Meaningful (~30%) Pain Improvement Ordered by decreasing estimated efficacy Limitations 1. Based on indirect comparisons. 2. Timeframe ~4 to 12 weeks. 3. Details on methods available in online supplement. Amitriptyline Venlafaxine Gabapentin Cannabinoids 25 Improve with treatment 25 Improve with placebo or no treatment 50 No improvement 17 Improve with treatment 25 Improve with placebo or no treatment 58 No improvement 15 Improve with treatment 25 Improve with placebo or no treatment 60 No improvement 9 Improve with treatment 25 Improve with placebo or no treatment 66 No improvement High Dose Opioids * *60-110mg oral morphine per day Pregabalin Duloxetine 18 Improve with treatment 25 Improve with placebo or no treatment 57 No improvement 16 Improve with treatment 25 Improve with placebo or no treatment 59 No improvement 13 Improve with treatment 25 Improve with placebo or no treatment 62 No improvement Improve with treatment Improve with placebo or no treatment No improvement 2018

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Page 1: Outcome: Meaningful (~30%) Pain Improvement...Neuropathic Pain: Pharmacotherapy Treatment Outcome: Meaningful (~30%) Pain Improvement Ordered by decreasing estimated efficacy Limitations

NeuropathicPain:PharmacotherapyTreatment

Outcome:Meaningful(~30%)PainImprovementOrderedbydecreasingestimatedefficacy

Limitations1. Basedonindirect

comparisons.2. Timeframe~4to

12weeks.3. Detailsonmethods

availableinonlinesupplement.

Amitriptyline

Venlafaxine

Gabapentin

Cannabinoids

25Improvewithtreatment

25Improvewithplaceboornotreatment

50Noimprovement

17Improvewithtreatment

25Improvewithplaceboornotreatment

58Noimprovement

15Improvewithtreatment

25Improvewithplaceboornotreatment

60Noimprovement

9Improvewithtreatment

25Improvewithplaceboornotreatment

66Noimprovement

HighDoseOpioids*

*60-110mgoralmorphineperday

Pregabalin

Duloxetine

18Improvewithtreatment

25Improvewithplaceboornotreatment

57Noimprovement

16Improvewithtreatment

25Improvewithplaceboornotreatment

59Noimprovement

13Improvewithtreatment

25Improvewithplaceboornotreatment

62Noimprovement

Improvewithtreatment

Improvewithplaceboornotreatment

Noimprovement

2018

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