osteomalacia
TRANSCRIPT
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Osteomalacia
Zaryab GhauriBatch E
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What is Osteomalacia?
Osteomalacia means soft bones often develops because of vitamin D deficiency.
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Who gets Osteomalacia?
Elder PeopleFamily History of RicketsBlack RaceSouth Asian Origin
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Bone Mineralization
Bone Mineral Hydroxyapatite[Ca10(PO4)6(OH)2]
Vitamin D(Metabolism)
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Vitamin D(Functions)
*Intestinal Calcium absorption
*Re-absorption of Calcium from Kidneys
*Interaction with PTH in regulation of blood Calcium
*Mineralization of Bone
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OsteoclastsOsteoblastsOsteocytesLining Cells
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Pathology in Osteomalacia
Inadequately mineralized Osteoid
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Causes Of Osteomalacia
1. Vitamin D deficiencyDietSun Exposure
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2. Gastrointestinal CausesGastricIntestinalBilliary
3. Renal CausesChronic Renal FailureRenal Tubular AcidosisLong term Renal DialysisFanconi Syndrome(Poisoning)
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4. Tumor Induced Osteomalacia5. Drugs
Phenobarbital (Pubmed)Acetazolamide(JAMA, Journal of the American Medical Association)
Ammonium Chloride (http://press.endocrine.org/doi/abs/10.1210/jcem-16-5-599)
Disodium Etidronate(http://www.ncbi.nlm.nih.gov/pubmed/10883448)
Flouride(http://fluoridealert.org/studies/osteoid02/)
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Symptoms
>50yrs ageBone PainMuscle WeaknessEasy Fractures
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Investigations
CBCElectrolytesLevels Of CalciumPhosphorusCalcium Phosphorus IndexVitamin DALPPTH
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Looser’s Zone
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Codfish Vertebrae
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Trefoil Pelvis
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Bone Scan
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Treatment
Sun ExposureDietVitamin D supplementation
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Prevention
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References
http://painreliveonlypt.blogspot.com/2014/10/osteomalacia-causes-risk-factors.html
http://www.arthritisresearchuk.org/arthritis-information/conditions/osteomalacia/what-is-osteomalacia.aspx
http://www.vitaminsestore.com/osteomalacia-causes-treatments-symptoms-and-risk-factors/