office of research and development photo image area measures 1.5” h x 7” and can be masked by a...
DESCRIPTION
Office of Research and Development 2 Data Sharing Pressures Decades-old call consistency and standardized procedures for collecting, storing, and reporting exposure-related information –Public Health: epidemiology, exposure limits, risk management NIH Data Sharing Policy (2003) –Data sharing plan included in application (>$500K) –OMB Circular A-110 – Applies to EPA as well Recently, REACH legislation has produced increased interest –Manufacturers/Importers required to consider likely exposures –Predictive tools are being developed Journals are being asked to require authors to include the basic data as supplementary materialTRANSCRIPT
November 3, 2009Office of Research and Development
Photo image area measures 1.5” H x 7” and can be masked by a collage strip of one, two or three images.
The photo image area is located 3.19” from left and 3.81” from top of page.
Each image used in collage should be reduced or cropped to a maximum of 1.5” high, stroked with a 1.5 pt white frame and positioned edge-to-edge with accompanying images.
Exposure Data StandardsPeter P. EgeghyNational Exposure Research Laboratory, U.S. Environmental Protection Agency
2Office of Research and Development
Need for Standards for Data Representation
•Purpose of Standards: Allow data to be efficiently stored, communicated, and interpreted
•Drivers for standardization of exposure data:
– Data sharing pressures
– Need for chemical prioritization
– Desire to “mainstream” exposure science
• Take the Zartarian/ISEA/IPCS effort to the next level
3Office of Research and Development
Data Sharing Pressures
•Decades-old call consistency and standardized procedures for collecting, storing, and reporting exposure-related information – Public Health: epidemiology, exposure limits, risk management
•NIH Data Sharing Policy (2003)– Data sharing plan included in application (>$500K)– OMB Circular A-110 – Applies to EPA as well
•Recently, REACH legislation has produced increased interest– Manufacturers/Importers required to consider likely exposures– Predictive tools are being developed
• Journals are being asked to require authors to include the basic data as supplementary material
4Office of Research and Development
Exposure-Based Chemical Prioritization
• Risk Assessment– Risk defined as Hazard x Exposure– Incorporate vital human exposure resources
• Accessible exposure databases facilitate:– Application of environmental informatics tools– Linkages with toxicity data (ACToR, DSSTox)– Linkages with product usage data– Large-scale, multidimensional data analysis
• Formal representation of key concepts and relationships
– Defines exposure domain and data structureBrazma et al., 2006 Genetics 7:593-605
5Office of Research and Development
Pulling Exposure Science away from the Fringe
• To further the scientific understanding of human exposure•Make existing human exposure data more accessible to:
– The broader science community•Reality = most of the “exposure assessment” for chemicals
management will not be performed by exposure scientists•Automated interrogation of databases is replacing hand-
interpretation of data– Established hierarchies and system of mapping is essential
– The public•Exposure data will reach the public•Example: AHHS written up in “Parade” and “Parenting” magazines
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Workgroup
•Establish a Workgroup for developing standards for data representation– Guidance from experts in the field– Include both generators and users
•Define the exposure domain– Develop a conceptual model– Specify how to describe and communicate data and information– Establish a minimal set of the most informative parameters
•Beyond consistent naming, coding, and formatting of data elements, a formal representation of key concepts and relationships
•Need your help!