oer fy14 budget projections - harvard university · oer powerpoint \(ppt\) template - 508 compliant...
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75th percentile = 2.84 25th percentile = 0.65
Median 1.39
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Most Common Journals
MGH-NIH Other NIH Not NIH
PNAS (2%) J Biol Chem (3%) PLoS ONE (1%)
J Biol Chem (2%) PNAS (2%) Phys Rev Let (<1%)
PLoS ONE (2%) PLoS ONE (2%) J Biol Chem (<1%)
J Clin Endocrin Metab (2%) J Immunol (1%) BMJ (<1%)
Neuro Image (1%) Biochem (1%) Lancet (<1%)
J Neurosci (1%) J Neurosci (1%) PNAS (<1%)
J Immunol (1%) J Virol (1%) Nature (<1%)
8
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“Payoffs from research follow a power law, with big, near-unlimited upside but limited downside. Since the winner will have an explosive payoff, the right approach requires a certain style of blind funding … [of] as large a number of projects as possible...” Nassim Nicholas Taleb
Some Other Thoughts …
Taleb N 2012 Random House
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Another Finish Line?
10 Shapiro D, Vrana K. PNAS 2015;112:9496-7
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Ability to Respond to Emergencies …
11
Science 2016;353:1094-5
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Rigor, Reproducibility, and …
12
Nature 2014;505:612-13
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Registration and Reporting (Fast) …
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“To realize the benefits of a clinical trial, the data must be broadly shared quickly. The DHHS has released a regulation for registration and summary results reporting. The NIH will withhold clinical trial funding if the agency is unable to verify adequate registration and results reporting…”
JAMA 2016 (online September 16, 2016)
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What We Care About – Research Output
14 Moses H et al. JAMA 2015;313:174-189
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Ivacaftor
FDA trials
Documents / Publications
Scientists (N=2587) Institutions (N=2516)
Sanders Williams R et al. Cell 2015;163:21-23
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A Metrics Story with Big Data
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Thanks Jim Onken, Brian Haugan, George Chacko, Shixin Jiang, Samet Keserci, Alex Pico, and Lindsay Wan
PCSK9 inhibitor
Trials
Foundational publications
NIH-supported organizations NIH grants
Cited References
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Why Should We Care? “Eroom’s Law”
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Scannell JW et al. Nature Reviews Drug Discovery 2012;11:191-200
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Why Might This Be Happening?
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Scannell JW et al. Nature Reviews Drug Discovery 2012;11:191-200
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Some Think Our Paradigm May be Wrong…
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Gittelman M. J Research Policy 2016;45:1570-85 Plenge RM et al. Nature Reviews Drug Discovery 2013;12:581-594
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20 http://www.nih.gov/sites/default/files/about-nih/strategic-plan-fy2016-2020-508.pdf
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Towards “Evidence-Based Funding” …
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Azoulay P. Nature 2012;484:31-32 Ioannidis J. Nature 2011; 477:529-31
“It is a scandal that billions of dollars are spent on research without knowing the best way to distribute that money.” John Ioannidis
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Looking Forward to Open Dialogue …
22 http://nexus.od.nih.gov/all/category/open-mike/