oddt - open drug discovery teams for collaboration
DESCRIPTION
Short overiew showing ODDT a new mobile app in alpha for open drug discovery teams. Illustration of genesis and development so far.TRANSCRIPT
![Page 1: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/1.jpg)
Open Drug Discovery Teams (ODDT): How our Collaboration Led to a New App For
Collaboration
Dr. Sean EkinsCollaborations in Chemistry, A division of Collaborations in
Communications, Inc.
Dr. Alex M. ClarkMolecular Materials Informatics, Inc.
![Page 2: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/2.jpg)
When Given a New Challenge How do You Respond?
• Mid January Pistoia Alliance Ask for volunteers to present in a Dragon’s Den Scenario Feb 8th at the RSC
• Ideas that will transform Pharma R&D in 2014• So my natural response was :“If I am going to take part I want to create something real”
![Page 3: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/3.jpg)
Why it is time to transform R&D – This is just one disease!
• Tuberculosis Kills 1.6-1.7m/yr (~1 every 8 seconds) equivalent to malaria• 1/3rd of worlds population infected!!!!• Extensively drug resistant increasing incidence• No new drugs in over 40 yrs • Drug-drug interactions and Cc-morbidity with HIV
• Recent years have seen increased investment from Bill and Melinda Gates Foundation (BMGF) etc.
• But no impact on new clinical candidates except from pharma• Pipeline is thin and weak• No data sharing on the scale of malaria• Open Source effort in India (OSDD) but no real international traction• Disconnected efforts - CDD, Pharmas, Academia, NIH• BMGF & NIH do not coordinate TB efforts, not mandating open data.
– Result data hoarding – still not learning from failure – thousands of compounds screened and not accessible
![Page 4: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/4.jpg)
Inspiration
• There are many 1000s of diseases and few with cures
• Science Online 2012 on open notebooks and data overload
• Could we create an app for science like Flipboard?
![Page 5: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/5.jpg)
So I started sketching on my iPad..
![Page 6: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/6.jpg)
How would we go about finding these teams?
![Page 7: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/7.jpg)
Can we create virtual teams of open researchers – we need a central hub to
integrate open science data
![Page 8: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/8.jpg)
Everything is on the cloud and the App becomes the glue for the team and projects
![Page 9: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/9.jpg)
How the App should look – note the Flipboard inspiration
![Page 10: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/10.jpg)
Sounding Boards are Very Important
• Antony J. Williams VP, Strategic development for ChemSpider at the Royal Society of Chemistry.
• Alex M. Clark is the founder of Molecular Materials Informatics, Inc.
• Alex said he could build the App
![Page 11: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/11.jpg)
Within about 10 days Alex Created ODDT to present at the Pistoia meeting
Focused on Tuberculosis, Malaria, HIV/AIDS, Huntington’s Disease, Sanfilippo Syndrome, and Green Chemistry as topics in version 1
We did not win the competition but had useful feedback – the need to articulate the value proposition
![Page 12: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/12.jpg)
The Value Proposition• The project is intended to bring together open data in a single aggregated
collection, and then facilitate forming open research teams around this data
• Disseminate important information to a highly relevant target audience
• Network and discover other researchers with complementary interests, and opportunities to collaborate
• Team members will be able to borrow and reuse a growing collection of existing Open data.
• The community as a whole can debate, contest or endorse data based on its quality.
• The app could also be used as a type of “lab notebook” whereby individual researchers share links (URLs) to content and the app aggregates these.
![Page 13: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/13.jpg)
Getting to the Free Alpha Version
• Added more topics – Chagas Disease, leishmaniasis
• Added voting• Added Stats page• Added datasheet viewing• ….Find testers
![Page 14: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/14.jpg)
Latest Layout9 Panels includes one on ODDT information
Can use multiple Twitter accounts Here is my icon
Stats summary
About App
![Page 15: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/15.jpg)
Tap on a panel and look at Incoming contents
Click here to endorse or disapprove
Click here to follow hyperlink
Incoming is sorted by time of creation
![Page 16: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/16.jpg)
Browse through multiple pages of tweets
![Page 17: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/17.jpg)
Endorse, Disapprove and Comment
![Page 18: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/18.jpg)
Endorse content or reject it
![Page 19: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/19.jpg)
Recent contents
Click on image to open it
Recent isfactoids with a vote count of +1 or better
![Page 20: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/20.jpg)
Content
Ranked content
Click on image to open it
Content is currently anything with a votecount of +1 or better, sorted by most popular first
![Page 21: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/21.jpg)
Tap on a link or image
![Page 22: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/22.jpg)
Be able to download content
![Page 23: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/23.jpg)
Look at your own statistics
![Page 24: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/24.jpg)
Exposing rare diseases – creating communities of research and sparking discussion
My tweets on recent analyses and ideas
My Retweets
![Page 25: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/25.jpg)
Summary
• From idea to alpha testing version in a month• Well on way to delivering a tool for R&D and
the general public• Future versions will allow user to specify
topics
![Page 26: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/26.jpg)
Coming Soon
• Rewards – badges• Image handling – HTML web crawling• Beta version• Presentation at ACS meeting• General release – Post ACS meeting• More ideas that may need funding to cover server etc• - Would you fund us if we posted ODDT on Kickstarter
or Petridish.org ??• Are there sponsors for specific pages or content?
![Page 27: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/27.jpg)
Thank you Alpha testers
• Antony J. Williams• Hans De Winter • Chris Swain • Andrew Lang • Carlo Yuvienco • Paul Reinheimer • Michael S. Lajiness• Nancy Connell • Greta Beekhuis • Joe Hupcey III• Freundlich, Joel• Tanya Parrish• Peter Olinga ODDTPhoto for San Fillipo Syndrome courtesy
of Jill Wood www.jonasjustbegun.org
![Page 28: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/28.jpg)
More Information
• Please contact us for further details or suggestions at: [email protected] and [email protected]
• You can learn more about the ODDT app at:
http://www.scimobileapps.com/index.php?title=Open_Drug_Discovery_Teams
And frequent blogs at http://www.collabchem.com and http://cheminf20.org/
![Page 29: ODDT - open drug discovery teams for collaboration](https://reader031.vdocuments.us/reader031/viewer/2022020217/54c265c54a795974748b45d3/html5/thumbnails/29.jpg)
Data to Appify?
• If you have Drug Discovery data or ideas that could be turned into an app please let us know
• Alex Clark has developed these other Apps