NUTRIENTS AS BIOLOGICAL RESPONSE MODIFIERS changing the way the body works to reverse cancer

IMMUNE REGULATORS, ELIMINATE INFECTIONS?

ALTER GENETIC EXPRESSION OF CANCER

CELL MEMBRANE DYNAMICS

DETOXIFICATION

PH MAINTENANCE, BALANCING PROTONS

PROOXIDANTS & AOX, BALANCING ELECTRONS

CELLULAR COMMUNICATIONS (signal cell transduction)

PROSTAGLANDIN REGULATION

STEROID HORMONE CONTROL

ENERGY METABOLISM: AEROBIC VS ANAEROBIC

PROBIOTICS VS DYSBIOSIS

ANTI-PROLIFERATIVE AGENTS

ALTER TUMOR PROTECTIVE MECHANISMS

APOPTOSIS, PROGRAMMED CELL DEATH

Change the rate of a reaction by: temperature

pH

surface area

concentration of substrates or enzymes

X y

enzyme niacin B-3

NAD

Recommended Dietary Allowances (RDA)"... do not cover

special nutritional needs arising from chronic diseases, and

drug therapies." National Research Council 1989

CAN INDOLE-3-CARBINOL (I3C) REVERSE

CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN)?

50

44

00

5

10

15

20

25

30

35

40

45

50

200 MG 400 MG PLCB

% CR

STUDY DESIGN: 30 women biopsy proven

CIN stage 2,3 given 200,

400 mg/day I3C or placebo

12 wk. CR in I3C

No toxicity observed.

Dose dependent response

Shifting 16 @hydroxyestrone

To 2 hydroxyestrone

Most HPV positive

P

time

health

metastatic

malignancy

anaplasia

metaplasia

dysplasia

death

DNA

repair

apoptosis

NK attack

anti-angiogenesis

tumor encapsulation

CAN NUTRIENTS REVERSE THE CANCER PROCESS?

INITIATION

PROMOTION

PROGRESSION

I-3-C reverses CIN

folate reverses bronchial metaplasia & cervical dysplasia

vitamin A and beta-carotene reverse oral leukoplakia

calcium reverses colon crypts/polyps

vitamin E reverses fibrocystic breast disease

neoplasia

HOW CAN NUTRIENTS AFFECT THE CANCER PROCESS?

Shklar, G., Alternative & Complementary Therapies, vol.2, no.3, p.156, May 1996

-inhibit angiogenesis

-dysregulate mutant p53 oncogene

-alter immune cytokines

Schwartz, JL, Cancer Prevention Intl., vol.3, p.37, 1997

-upregulate DNA repair

-augment programmed cell death (apoptosis)

Prasad, KN, et al., Arch.Otolaryngol.Head Neck Surg., vol.119, p.1133, Oct.1993

-regulate gene expression

-induce growth inhibition in cancer

-alter cell differentiation

Lupulescu, A., Intl.J.Vit.Nutr.Res., vol.63, p.3, 1993

-A, C, E regulators of cell differentiation, membrane biogenesis, DNA synthesis

-A, C, E may be cytotoxic and cytostatic in certain cell system

-affect oncogenes

Poppel, GV, et al., Cancer Letters, vol.114, p.195, 1997

-immune stimulation

-enhancement of cell to cell communication, defuse carcinogens, etc.

CAN THERAPEUTIC NUTRITION

LOWER TUMOR RECURRENCE?

0

10

20

30

40

50

60

70

80

90

100

RDA suppl. hi dose nutr

10 mo.actual

5 yr projected

% of bladder cancer patients with tumor recurrence source: Lamm, DL, J.Urol.,151, 21, Jan.1994

Study design: 65 patients w.

transitional cell carcinoma of

bladder, BCG immune tx,

randomized to either RDA

supplement 24 of 30 with

tumor recurrence) or RDA +

40,000 iu A, 100 mg B-6,

2 gm C, 400 iu E, 90 mg Zn

with 14 of 35 recurrence.

Hi dose nutrients cut tumor

recurrence in half.

-50%

CAN FISH OIL IMPROVE OUTCOME

IN CANCER TREATMENT?

anti-cachectic: prevents & reverses wasting syndrome Ross, JA, Curr.Opin.Coin.Nutr.Metab.Care, vol.2, no.3, p.219, May 1999

induces apoptosis in cancer cells Hardman, WE, J.Nutr., vol.132, no.11 suppl, p.3508S, Nov.2002

upregulates immune function Kelley, DS, Nutrition, vol.17, no.7, p.669, Jul 2001

reduces stickiness of cells to slow metastasis

competes with omega-6 arachidonic acid metabolites Woutersen, RA, Mutat.Res., vol.443, no.1, p.111, Jul.1999

improves insulin sensitivity, lowers blood glucose

impairs tumor angiogenesis Rose, DP, Nutr.Cancer, vol.37, no.2, p.119, 2000

DOES FISH OIL SUPPLEMENTATION AS SOLE THERAPY

IMPROVE OUTCOME IN PATIENTS WITH SOLID TUMORS?

“Omega 3 prolonged survival of all patients…resulted in significant

(p

CAN NUTRIENTS EXTEND LIFESPAN IN

POST-SURGICAL (NSC) LUNG CANCER PATIENTS

41

11

0

5

10

15

20

25

30

35

40

45

VITAMIN

USERS

NON-VIT

USERS

MEDIANSURVIVALMONTHS

STUDY DESIGN:

36 post-operative

NSC lung ca ptns

evaluated: diet hist,

supplement usage,

serum folate charted;

Exclusion: 2/d),folate

antagonists.

RESULTS: "Patients (19)

took vitamin supplements

more likely to be long

term survivors." p=.002

Source: Jatoi, A, et al., J.Surg.Oncol., vol.68, no.4, p.231, 1998

FAT CHO

APPLIED HUMAN

CLINICAL NUTRITION

OXYGEN WATER

PROT FIBER

VITAMINS MINERALS

MDC CEN minor dietary

constituents conditionally essential

nutrients

QUASI-VIT

OTHERS

SURVIVING

THRIVING

QuickTime™ and aDV/DVCPRO - NTSC decompressor

are needed to see this picture.

Nature to be commanded must be obeyed.

Sir Francis Bacon (1561-1626)

founder of scientific inquiry

Florida State University fsu.edu

"Look deep into nature and then you will understand

everything better." Albert Einstein

MOST POPULAR GROCERY ITEMS IN AMERICA

1. Marlboro cigarettes

2. Coke Classic

3. Pepsi Cola

4. Kraft processed cheese

5. Diet Coke

6. Campbell’s soup

7. Budweiser beer

8. Tide detergent

9. Folger’s coffee

10. Winston cigarettes

from “1992 Top Ten Almanac”

by Michael Robbins

TOP 3 VEGGIES IN AMERICA:

CATSUP, FRENCH FRIES, ONION RINGS

% OF AMERICANS NOT EATING THE RDA

Recommended Dietary Allowance=92%

0

10

20

30

40

50

60

70

80

A B-1 B-2 B-3 B-6 B-12 C Ca Fe Mg

% below RDA

Paleolithic vs. Modern Diet

% kcal protein

% kcal sucrose

% kcal fat

% PUFA in fat

PUFA/sat. ratio

Fiber gm/day

Sodium mg/day

Calcium mg/day

Vit. C mg/day

Source: Paleolithic Prescription by Eaton, Shostak, Konner, Harper & Row, 1988

12

19

42

Beef 2

0.44 20

~6900

740

90

33

~0

21

Grouse 60 1.41

100+

690

1500+

440

Modern U.S. Diet Paleolithic Diet

SAN DIEGO WILD ANIMAL PARK

NUTRIENT INTAKE IS CRUCIAL FOR ALL PLANTS

AND ANIMALS ON EARTH

but not for humans?

Can a healthy lifestyle lower overall mortality? Hale Project: 1507 healthy men + 832 women, ages 70-90, 11 countries

Europe, 12 year followup (1988-2000), adherence to Mediterranean diet,

exercise, no smoking, moderate alcohol

Conclusions: "adherence to a Mediterranean diet and healthful lifestyle is

associated with a more than 50% lower rate of all-causes mortality." (95%CI)

Knoops, KT, JAMA, 2004;292:1433-9

77

63 65

78

35

100

0

10

20

30

40

50

60

70

80

90

100

Med

diet

Exer No

smok

Mod

alco

All

Haz ratio

REASONS FOR OMNIVOROUS DIET

CARNIVORE NUTRIENTS

conjugated linoleic acid (CLA)

eicosapentaenoic acid (EPA)

cartilage (glycosaminoglycans)

carnitine

CoQ

B-12

zinc

quarternary amino acid sequence

biological value of protein

HERBIVORE nutrients

carotenoids (lycopene 800+)

bioflavonoids (quercetin 20,000)

anthocyanins (red in fruit/veg)

allylic sulfides (garlic, onion)

fucoidans (seaweed)

sterolins (beta sitosterol)

piperine (black pepper)

capsicum (red pepper)

fiber (butyrate)

lignans (flax, wh.grains)

potassium

anti-fungals (veg., mushr.,kelp)

chlorophyll

phytic acid (IP6, wh.grains)

veg-e-tar-i-an (n.)

1. One who practices vegetarianism.

2. A herbivore.

3. Native American phrase "bad hunter"

LOOKING AT A HEALTHY MEAL PLATE

tomato,spinach,carrot,peppers,

fruit,broccoli,cabbage,onion,etc

oatmeal,beans,bread,tortilla

pasta,yams,nuts,grains,

legumes,cooked vegetables

fish, wild game, poultry,

lean beef,eggs,br.yeast

beans, dairy,spirulina,kelp

1/3 1/3

1/3

raw fr/veg lo fat/hi pro

cooked whole plant food

ORAC: OXYGEN RADICAL

ABSORBENCE CAPACITY

sponges for free radicals ORAC/5 GM

prunes 288

raisins 141

blueberries 111

blackberries 101

garlic 96

kale 88

cranberries 87

strawberries 76

spinach raw 60

plum 47

"...reduce risk of diseases of aging

by adding high ORAC foods to diet."

Floyd Horn, PhD, Tufts Univ.

need 3000-5000 ORAC units/day

(food & supplements)

average US intake 1200 ORAC

NUTRITIONAL DEFICIENCIES time required to develop condition

O2 H2O C A

days

Ca Cr/E EPA,CoQ

et al.

0.003 2

30

180

14,600 14,600

16,425

?

ADAPTIVE FORCES OF NATURAL SELECTION

(AFONS) FROM TOXIC TO ESSENTIAL

reaction

from

organism

time (eons)

toxic tolerated

essential

oxygen

sunlight

gut flora

selenium

blood sugar

iron

iodine

indole 3 car

quercetin

WINDOW OF EFFICACY “First, do no harm.”

TOO MUCH CAN BE TOXIC

TOO LITTLE CAN BE INEFFECTIVE

DRUGS IRON VIT A

calcium

magnes

SELENIUM VIT C

B VIT

The difference between a medicine and a poison is dosage.

ANNUAL CAUSES OF DEATH IN AMERICA CDC, Nat.Ctr Health Stat, JAMA, Consumer Prod.Safety Comm.

400,000 Tobacco

125,000 Alcohol

140,000 RX drugs

42,000 Auto accidents

36,000 Flu

9100 Food contamination

3300 Aspirin, bleeding

1064 Boating accidents

800 Bicycles

32 Skiing accidents

17 Hair dryers

15 Power lawn mower

4 Vending machine crushing

0 All vitamin supplements

1? Commercial herb products, mahuang

source:Willner, C, Alt.Ther.,

10,4, 26, July 2004:

Michelle Moore

Diagnosed May 2000

terminal kidney (renal) cancer

given 2 months to live

Alive and well as of Jan.2003

CAN GAMMA LINOLENIC ACID IMPROVE OUTCOME

IN BREAST CANCER TREATMENT? Kenny, FS, et al., Int.J.Cancer, vol.85, p.643, 2000

4

16

3026

49

37

1721

COMPL

RESP

PART

RESP

STAT DIS PROGR

DIS

TAMOXIFEN TAM + GLA

STUDY DESIGN: 47 elderly endocrine sensitive

br.ca. patients received

tamoxifen as 1st line tx

(controls) compared to 38

matched patients receiving

tamoxifen (20 mg od) +

gamma linolenic acid 2.8 g/d.

No drop outs & no side

effects in 42% exper. group.

Results at 6 mo. after

beginning tx.

"Phase 2 study suggests high

dose oral GLA to be a

valuable new agent in tx

ER/PR br.ca."

DOES DIETARY FLAXSEED INFLUENCE

METASTASIS OF MELANOMA IN MICE?

155

106

7257

0

20

40

60

80

100

120

140

160

#TUMORS/MOUSE

CONTROL DIET 2.5% flaxseed

5% flaxseed 10% flaxseed

Lin, Y., et al., Cancer Letters, vol.124, p.181, 1998

P

Synergism of Chemopreventive Nutrients

0

20

40

60

80

100

Study design: female rats (15-30/group) exposed to 30 mg total DMBA begin at day 50 after birth, provided nutrient supplements from d 40-240; Rao, AR, et al, Jpn J Ca Res, vol 81, p 1239, Dec 1990

DMBA Se Mg C A Se+A Mg+C Mg+C +A

C+A+ Se+Mg

C+A +Se

C+A

100

52

46

57

48

30 26

16 12

23

35

1 nutrient

2 nutrients

3 nutrients

4 nutr

% Animals with Tumors

DOES NUTRITION IMPROVE OUTCOME?

over 900 trees planted (5 year survivor)

75% of our patients are refractory...failed therapy

NUTRITION SUPPLEMENTS AGAINST CANCER

return on investment: risk/benefit/cost ratio

CORE: broad spectrum vit/min

extra C: 1-12 grams, buffered

extra E: 400 iu mixed

400 iu succinate

cod liver oil: 1 T/d, 20 caps

green tea

curcumin

BONUS: tolerate,afford? CLA, GLA

enzymes

thymus extract

bovine cartilage

garlic

probiotics

lipoic acid

CoQ

curcumin

silymarin

Maitake D-fraction

alkylglycerol (shark oil)

green tea

DISEASE-SPECIFIC prostate: lycopene

breast: cal-d-glucarate

colon: anti-fungal

lung: CoQ, vit.A

ADJUVANT NUTRITION IN

CANCER TREATMENT BASIC diet: whole foods. omniv

-perimeter store

-perishable/sprout

-little or no label

-1/3 plate guide

protein (60-100 gm/d)

low glycemic/no sugar

no trans fats

high color vegetable*/fruit

supplements

-multi vit/min

-fish oil cap

-vit. C 1 gm/d

-AOX multiple

ADVANCED detect underlying cause of

failed homeostatic mech.

detect food allergies

supplements:

1-3 tsp fish oil

GLA

CLA

vit.D (2000-5000 iu)

green tea

CoQ

selenium

IP6

curcumin (curry)

fucoidan (seaweed)

HERBAL MEDICINE AS SUPPLEMENTS:

echinacea

astragalus

Cat’s claw

Pau D’arco

ginseng

grape seed extract

aloe vera

red clover

milk thistle

Essiac

Hoxsey

Flor-Essence

AS SEASONINGS:

garlic

onion

hot peppers

cinnamon

ginger

real licorice

turmeric (curry)

parsley

sage

chicory

thyme

basil

AS FOODS:

soy

green & orange

dandelion greens

citrus

tomato

green tea

broccoli/cabbage

beets

sprouts

flaxseed meal

sesame seeds

Maitake mushrm

HEALTHY SEASONINGS: HERBAL MEDICINE?

COMPREHENSIVE CANCER

TREATMENT INCLUDES:

change underlying

cause(s) of disease

NUTRITION

DETOXIFICATION

DYSBIOSIS

HORMONE BAL.

HYPERGLYCEMIA

INFECTIONS

STRESS

EXERCISE

ENERGY PATHWAYS

ETC.

restrained tumor

debulking

CHEMO?

RADIATION

SURGERY

BURZYNSKI

HYPERTHERM

PHOTO-CYTO

HERBALS

APHERESIS

LYMPH.INFUS.

symptom

management

PAIN**

NAUSEA

ANOREXIA

ANEMIA

LEUKOPENIA

DEPRESSION

CACHEXIA

HAIR LOSS

1 2 3

COMPLETE HOST DEFENSE MECHANISMS

person's life force

METAPHYSICAL

protection: spirit, love,

purpose, expression,

social network, touching

PHYSICAL protection:

nutrition, avoid toxins,

exercise, sun, fresh air,

body alignment

BOB HOPE 100 YR

GEORGE BURNS 99 YR

MILTON BERLE 93 YR

WHAT DO THESE "LONGEVITY EXPERTS"

HAVE IN COMMON?

Art Linkletter 1912-? 93 yr

Groucho Marx 87 yr

Jack LaLanne 1915-? 91 yr

STRESS AND DISEASE what you are eating may not be as important as what's eating you

STRESS AND DISEASE what you are eating may not be as important as what's eating you

-Selye and General Adaptation Syndrome

atrophied thymus, erosion of gastric mucosa, elevated serum lipids

-Krebiozen cancer drug

-Cousins "galloping heart"

-placebo effect, sometimes equal to active drug

-sympathetic (fight or flight) vs parasympathetic nervous sys.

-ACTH alters other hormone pathways, growth, thyroid, etc.

-relaxation proven to help many ailments: physical & mental

-live life at your own pace

-lean on a "Higher Power"

-rest often

-Galen Clark story

DETOXIFICATION TOXINS: lower immune functions & damage DNA

BODY POOL OF

TOXINS

AIR 50 million breathe polluted air

FOOD 1.2 bil. lb. pest. 4 mil. lb. antibiotic 2800 FDA additives

WATER 40% fresh water unusable 1300 pollutants in typical drink. OTHER

Hg amalgam EMF

URINE water, C, beans, chelation

FECES fiber, fluid psyllium, sena, probiotic

SWEAT skin largest organ exer, hot tub fever, jacuzzi

LIVER garlic, silymarin, Se & E, glutathione

CHEMICAL RELEASES IN THE US

scorecard.org

HAZARDOUS AIR POLLUTANTS CANCER RISK

scorecard.org

SMOG AND PARTICULATE EMISSIONS IN US

scorecard.org

EPA SUPERFUND CLEANUP SITES IN US

scorecard.org

GALEN CLARK 1814-1910

"I went to the mountains to take my chances of dying or getting

better; which I thought were about even."

BEATING

CANCER

WITH

NUTRITION 4th edition 2005

By Patrick Quillin, PhD,RD,CNS

NutritionCancer.com

Harnessing the incredible healing power of

nature and science for medically-treated

cancer patients.