Novocastra HD - GynepathologyHighly Definitive Antibodies

Trust the HD Difference – Highly Definitive Antibodies for Diagnostic Confidence• Independently benchmarked against leading equivalents by external QA*

• Establishing a new quality standard in IHC; simplifying antibody selection

*Independent analysis commissioned by Leica Biosystems and conducted by NordiQC according to the manufacturers’ instructions for use and on the corresponding staining platform.

BOND 7 mL PA0270

BOND 30 mL PA0131

Liquid 1 mL NCL-L-CD10-270

CD10 Clone 56C6

BOND 7 mL PA0007

Liquid 1 mL NCL-L-CD117-032

Human Gastrointestinal Stromal TumorIntense membrane staining of tumor cells.

CD117 (c-kit Oncoprotein)

Clone EP10 Cytokeratin 5 Clone

XM26

BOND 7 mL PA0468

Liquid 0.5 mL NCL-L-CK5

Liquid 1 mL NCL-L-CK5

Cytokeratin 7 Clone RN7

BOND 7 mL PA0942

BOND 30 mL PA0138

Liquid 1 mL NCL-L-CK7-560

Human Lymphoblastic LymphomaIntense membrane staining of neoplastic lymphoid cells.

Ductal Carcinoma In SituIntense staining of myoepithelial cells.

Epithelial Myoepithelial CarcinomaThe luminal cells show intense staining with CK7 in comparison with the weaker staining of the abluminal (myoepithelial) cells.

Human Colonic Mucinous AdenocarcinomaCytoplasmic and membrane staining of absorbative intestinal epithelial cells and malignant tumor cells.

Carcinoembryoinic Antigen (CD66e)

Clone COL-1

BOND 7 mL PA0848 NEW

Liquid 1 mL NCL-L-CEA-609 NEW

Human Adenocarcinoma of EndometriumCytoplasmic and extracellular staining of malignant glandular endometrial cells.

CA125 Clone OV185:1

BOND 7 mL PA0539 NEW

Liquid 1 mL NCL-L-CA125 NEW

Novocastra HD - Gynepathology

Estrogen Receptor Clone 6F11

BOND 7 mL PA0151

BOND 30 mL PA0009

Liquid 1 mL NCL-L-ER-6F11

Liquid 2mL NCL-L-ER-6F11 N/A USA

Ki67 Clone MM1

BOND 7 mL PA0118

BOND 30 mL PA0410

Liquid 1 mL NCL-L-Ki67-MM1

Human Ductal Carcinoma Intense staining of a proportion of breast cancer cells.

Human Squamous Cell CarcinomaNuclear staining in a high proportion of malignant cells.

Mismatch Repair Protein (MLH1)

Clone ES05

BOND 7 mL PA0610

Liquid 1 mL NCL-L-MLH1

Invasive Ductal Carcinoma High ExpressorIntense nuclear staining in nearly 100% of tumor cells.

Human TonsilNuclear staining in the majority of proliferating lymphocytes.

Liquid 1 mL NCL-L-MSH2

Mismatch Repair Protein (MSH2)

Clone 25D12

BOND 7 mL PA0057

Liquid 0.5 mL NCL-L-p53-D07

Liquid 1 mL NCL-L-p53-D07

p53 Clone DO-7

Human Ductal Carcinoma Intense nuclear staining of tumor cells.

Cytokeratin 20 Clone Ks20.8

BOND 7 mL PA0022

BOND 30 mL PA0037

Liquid 0.5 mL NCL-L-CK20

Liquid 1 mL NCL-L-CK20

Human ColonIntense staining in the crypts.

Human SeminomaStrong membrane and cytoplasmic staining of malignant cells.

BOND 7 mL PA0161

Placental Alkaline Phosphatase (PLAP)

Clone 8A9

BOND 7 mL PA0312

Liquid 1 mL NCL-L-PGR-312

Liquid 2mL NCL-L-PGR-312/2 N/A USA

Progesterone Receptor

Clone 16

BOND 7 mL PA0640

Liquid 0.5 mL NCL-L-VIM-V9

Liquid 1 mL NCL-L-VIM-V9

BOND 7 mL PA0562

Liquid 1 mL NCL-L-WT1-562

Vimentin Clone V9 Wilms’ Tumor Clone

WT49

Breast CarcinomaNuclear staining in a proportion of tumor cells.

Spindle Cell CarcinomaA spindle cell carcinoma showing intense vimentin staining.

Human Kidney, Wilms’ TumorNuclear staining of invasive tumor cells.

BOND 7 mL PA0943

Liquid 1 mL NCL-L-SMA

Human LeiomyosarcomaCytoplasmic staining of smooth muscle of vascular elements and of tumor cells.

Smooth Muscle Actin, Alpha (SMA)

Clone αsm-1

Human Testis, SeminomaIntense staining of pluripotent tumor cells.

BOND 7 mL PA0193 NEW

Liquid 1 mL NCL-L-OCT3/4

Oct-3/4 Clone N1NK

LeicaBiosystems.com

Novocastra HDHighly Definitive Antibodies

Benefits of BOND Ready-to-Use antibodies

✓ Optimized for staining performance on BOND

✓ Validated antibody concentrations

✓ Ease of use: just plug and play

✓ Increase standardization through automation

✓ Eliminate variability in antibody preparation

Benefits of concentrated liquid antibodies

✓ Flexibility of use on various platforms1

✓ Adaptable to a variety of detection systems1

✓ Adjustable concentration to suit user’s tissue1

✓ Economical option that retains confidence in clone selection

1. The performance of antibodies should be validated when used with automated platforms or manual staining systems other than stated on Instructions for Use.

Improve workflow efficiency and streamline validation.

95.13346 Rev C · 03/2016 · Copyright©2016 Leica Biosystems Newcastle Ltd. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH. Novocastra and BOND are trademarks of Leica Biosystems and its affiliates. Other logos, product and/or company names might be trademarks of their respective owners. The EP clones have been created by Epitomics Inc., using Epitomics’ proprietary rabbit monoclonal antibody technology covered under Patent No.’s 5, 675, 063 and 7, 402, 409.

Independently Evaluated* Specifically SelectedEach antibody in the range has been independently evaluated* by external QA, NordiQC, in comparison with equivalent products from other vendors. The range represents the highest performing antibodies that Leica Biosystems offers for the most commonly performed IHC tests.

*Independent analysis commissioned by Leica Biosystems and conducted by NordiQC according to the manufacturers’ instructions for use and on the corresponding staining platform.