non-pharmacologic management of delirium: an abcdef … safety and... · clinical subtypes of...
TRANSCRIPT
![Page 1: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/1.jpg)
Non-Pharmacologic Management of Delirium:
An ABCDEF Approach
Michele C. Balas PhD, RN, APRN-NP, CCRN-K, FCCMCenter of Excellence in Critical and Complex Care
The Ohio State University College of Nursing
Columbus, Ohio, USA
![Page 2: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/2.jpg)
Disclosures:
Dr. Balas has received research funding from the Alzheimer’s
Association, the Robert Wood Johnson Foundation, the UNMC
College of Nursing and the John A. Hartford Foundation. She
has no industry related conflicts of interest regarding the
content of this presentation.
![Page 3: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/3.jpg)
• Identify potentially modifiable risk factors for delirium
• Explore the evidence-based ABCDEF bundle & other non-
pharmacologic interventions aimed at reducing delirium &
improving outcomes for patients and families experiencing
an acute illness
Objectives
![Page 4: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/4.jpg)
Kaukonen JAMA 2014;311:1308-16
Critically ill with sepsis
Critically ill non-sepsis
Mortality from Critical Illness is Decreasing
Adjusted Odds Ratio
2.01.00.4
2000
2012
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
Year of ICU Admission
![Page 5: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/5.jpg)
‘08‘99 ‘05‘00 ‘04‘01 ‘03‘02 ‘07‘06
200,000
0
100,000
150,000
250,000
50,000
Iwashyna J Am Geriatric Soc 2012;60:1070-77
Long-term Survivors from Severe Sepsis
Number of New
Survivors
Year in which patient reached survivorship
3-Year Survivors
5-Year Survivors
![Page 6: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/6.jpg)
Wunsch JAMA 2010; 303: 849-856
Society of Critical Care Medicine, Critical Care Statistics in the United States, 2012
Annually
Adults Survive a Critical Illness
![Page 7: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/7.jpg)
© r
usty
rho
de
svia
Flic
kr
40-70%Cognitively
Impaired
Jackson AJRCCM 2010; 182: 183
Girard Crit Care Med 2010; 38: 1513
Wolters Intensive Care Med 2013; 39: 376
Pandharipande, et al. NEJM 2013;269:1306-1316
![Page 8: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/8.jpg)
Latronico Lancet Neurol 2011; 10: 931
60-80%Physically
Impaired
Ma
rce
l O
oste
rwijk
via
Flic
kr
![Page 9: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/9.jpg)
© lu
ma
ph
oto
gra
ph
y v
ia F
lickr
10-30%Mental Health
Impairments
Davydow DS Intensive Care Med 2009;35:796-809
Davydow DS Psychosom Med 2008;70:512-9
Wunch H JAMA 2014;311:1133-42
Jackson JC Lancet Respir Med 2014;2:369-79
![Page 10: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/10.jpg)
Post-Intensive Care Syndrome (PICS)
Needham Crit Care Med 2012; 40: 502-09
Elliott Crit Care Med 2014;42:2518-2526
Cognitive Impairments
Mental Health Impairment
Physical Impairments
![Page 11: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/11.jpg)
Psychological Symptoms
Managing Emotions (Grief)
Quality of Life (Death)
Needham Crit Care Med 2012; 40: 502-09
Elliott Crit Care Med 2014;42:2518-2526
Family Post-Intensive Care Syndrome (PICS-F)
Financial Implications
![Page 12: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/12.jpg)
Creditor MC Ann Intern Med 1993;118:219-23
Krumholz HM NEJM 2013;368:100-2
Not Just the Critically Ill
![Page 13: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/13.jpg)
![Page 14: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/14.jpg)
Similarities to Cancer Literature
Acute survivorshipTime when a person is being diagnosed &/or in treatment for cancer
Extended survivorshipTime immediately after treatment is completed, usually measured in months
Permanent survivorshipA longer period of time, often meaning that the passage of time since treatment is measured in years
American Society of Clinical Oncology. Cancer.Net. 2015. http://www.cancer.net/survivorship. Accessed November 10, 2015.
![Page 15: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/15.jpg)
?
![Page 16: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/16.jpg)
Low mobility is common in the hospital
100
0
60
40
80
20
Day 1
12P
Day 2
12A
Day 3
12A
Day 4
12A 12P 11P12P12P
Mean
Percent
of Time
Lying
Sitting
Standing/Walking
Brown J Am Geriatric Soc 2009;57:1660-1665
N=45
![Page 17: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/17.jpg)
ICU-Acquired Weakness & Mortality
Ali N, et al. Am J Respir Crit Care Med 2008;178:261-8
Quartiles of MRC Score
20
30
10
0
29.4%
1 2 3 4
In-hospital
Mortality
(%)
Weakest Strongest
9.1%
4.2% 6.2%
40
P=0.001
N=136
![Page 18: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/18.jpg)
1. Delirium = inattention
2. Develops over a short period of time, represents an acute
change from baseline & fluctuates in severity
3. Additional cognitive domain involved
4. Not occurring during coma
American Psychological Association Diagnostic and Statistical Manual of Mental Disorders 2013, 5th Ed.
![Page 19: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/19.jpg)
Delirium is the Strongest Independent Predictor
of Cognitive Impairment
0 2 4 6 8 10
70
60
80
90
N=382
P=0.004 for 0 vs. 5 days of delirium
RBANS
Global
Cognitive
Score
Days of ICU Delirium
Pandharipande, et al. NEJM 2013;269:1306-1316
![Page 20: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/20.jpg)
Pisani MA. Am J Respir Crit Care Med. 2009;180:1092-1097
Time to Death (Days)0 75 150 225 300 375 450
0
0.2
0.4
0.6
0.8
1.0
Survival
Probability
0 days
1-2 days3-4 days
5-9 days
10+ daysHR, 1.10; 95% CI, 1.03–1.18; p < .001
Delirium & Mortality
![Page 21: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/21.jpg)
Delirium, Why We Should Care
• Increased ICU & hospital LOS
•↑ restraints & sedative medications
• Poor functional recovery
• New institutionalization
• Multiple complications
• Total $143 billion to $152 billion nationally
•l 1-year health-care costs
![Page 22: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/22.jpg)
![Page 23: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/23.jpg)
Predisposing Risk Factors
• Advanced age• Dementia or other forms of cognitive impairment• Functional impairments• Medical & Psychiatric comorbidities• Drug or ETOH withdrawal• Male• Sensory impairment• APO E4 polymorphism
![Page 24: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/24.jpg)
![Page 25: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/25.jpg)
Precipitating Risk Factors
• Acute cardiac, neurologic, pulmonary or infectious event• Surgery• Severity of illness• Fluid & electrolyte imbalances• Immobility/bed rest/restraints• Mechanical ventilation• Indwelling tubes/catheters• Sleep deprivation• Uncontrolled pain• Medications
• Anticholinergic agents, benzodiazepines, opioids, more than 3 medications added
![Page 26: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/26.jpg)
Date of download: 7/11/2016Copyright © 2016 American Medical
Association. All rights reserved.
From: Effectiveness of Multicomponent Nonpharmacological Delirium Interventions: A Meta-analysis
JAMA Intern Med. 2015;175(4):512-520. doi:10.1001/jamainternmed.2014.7779
Meta-analysis of Delirium Incidence and Falls Eleven studies measured delirium incidence. Three randomized or matched trials and 5 non–randomized or
matched trials demonstrated significant reductions in delirium incidence. P < .001, and heterogeneity was low at I2 = 18%. Weighting was assigned according to
the inverse of the variance. Odds ratios less than 1 indicate decreased delirium incidence. Four studies examined the number of falls per patient-days.
Individually, only Stenvall et al (a randomized or matched trial) demonstrated significant reduction in the number of falls. P < .001, and heterogeneity was low at
I2 = 0%. Weighting was assigned according to the inverse of the variance. Odds ratios less than 1 indicate decreased rate of falls. NNT indicates the number
needed to treat.
![Page 27: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/27.jpg)
A
D
E
C
F
B
ABCDEF BundleAssess, prevent, & manage pain
Both SAT & SBT
Choice of analgesia & sedation
Delirium: Assess, prevent, & manage delirium
Early Mobility & Exercise
Family Engagement & Empowerment
Balas, M.C., et al., (2015). Critical Connections. 14(4); 1, 10.
![Page 28: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/28.jpg)
A
D
E
C
F
B
ABCDEF Team Approach
Nurse
Physician
Pharmacist
PT/OT
Respiratory
![Page 29: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/29.jpg)
A
• Why– Incidence
– Outcomes
• How– NRS, BPS, CPOT
– Pharmacologic interventions
– Nonpharmacologic interventions
– Proxy responders
AAssess, prevent, & manage pain
Puntillo K. Am J Crit Care, 2001;10:238-251; Payen J. Crit Care Med. 2001;29:2258-2263; Gelinas C. Am J Crit Care. 2006;15: 420-27; Payen J.
Anesthesiology. 2009; 111: 1308-16 ; Chanques G. Crit Care Med. 2010;151: 711-721; Gelinas C. Int J Nursing Stud. 2011;48: 1495–1504; Puntillo K. Crit
Care Med. 2012;40: 2760-2767; Puntillo K. Am J Respir Crit Care Med. 2014; 89: 39-47
![Page 30: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/30.jpg)
A protocol of “No Sedation”113 randomized
58 to control55 to intervention
Morphine PRNMorphine PRN
Cont. propofolHaloperidol PRN
Strom T, et al. Lancet 2010;375:475-80
6 hr propofol
Cont. propofol
Ramsay 3-4
Daily interruption
![Page 31: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/31.jpg)
Analgosedation: ICU Length of Stay
0
Days
70
20
40
60
80
100
Patients
Remaining
in ICU
(%)
14 21 28
Intervention (n=55)
Control (n=58)
Strom T, et al. Lancet 2010;375:475-80
p=.03
ICU stay reduced by 9.7 days
![Page 32: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/32.jpg)
B• Why
– Incidence
– Outcomes
• How
– Daily safety screen &
success/failure criteria
– Importance of RT & RN
coordination
– Opt out method
BBoth SATs &
SBTs
Ely E. N Engl J Med. 1996;335:1864-9; Riker R. (SAS) Crit Care Med. 1999; 27:1325-9; Kress J. N Engl J Med. 2000;342:1471-7; Sessler C. (RASS) Am J
Respir Crit Care Med. 2002, 166:1338-44; Ely E. (RASS) JAMA. 2003;289:2983-91; Girard T. Lancet. 2008;371:126-34; Strøm T. Lancet. 2010;375:475-80;
Shehabi Y. Am J Respir Crit Care Med. 2012;186:724-31; Balas M. Crit Care Med. 2013;42:1024-36; Klompas M. Am J Respir Crit Care Med. 2015;191:292-
301.
![Page 33: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/33.jpg)
ABC—study design
336 randomized
168 to control168 to intervention
Daily SBT
Daily SAT
Daily SBT
1 year follow-up 1 year follow-up
Girard TD, et al. Lancet 2008;371:126-34
![Page 34: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/34.jpg)
Coordinated SAT+SBT approach is associated
with a 14% reduction in mortality at 1 year.
Patients
Alive (%)
Girard TD, et al. Lancet 2008;371:126-34
00
20
40
60
80
100
60 12
0
18
0
24
0
30
0
36
0Days
p=.01
NNT to save 1 life: 7
SAT+SBT (n=167)
Usual Care+SBT (n=168)
![Page 35: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/35.jpg)
C
• Why
– Incidence
– Outcomes
• How
– Rounding
– Target sedation score
– Pharmacist driven
CChoice of
analgesia &
sedation
Riker R. Crit Care Med. 1999; 27:1325-9; Kress J. N Engl J Med. 2000;342:1471-7.; Sessler C. Am J Respir Crit Care Med. 2002, 166:1338-44; Ely E. JAMA.
2003;289:2983-91; Girard T. Lancet. 2008;371:126-34; Strøm T. Lancet. 2010;375:475-80; Shehabi Y. Am J Respir Crit Care Med. 2012;186:724-31; Bassett
R. (IHI ABCDE Collaborative) Jt Comm J Qual Patient Saf. 2015;41:62-74.
![Page 36: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/36.jpg)
Shehabi Y, et al. AJRCCM 2012;186:724-731
100
Deep Sedated (RASS -3 to -5)
Light Sedated (RASS -2 to +1)
Every deep sedation increases
the risk of death at 6 months
0 30 60 90 120 150 180Days
75
Patients
Alive
(%)
0
25
50
p=0.048
N=251
![Page 37: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/37.jpg)
Targeted Level of Consciousness
Choose Target Level of Consciousness
Assess Actual Level of Consciousness
Modify Treatment so Actual = Target
![Page 38: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/38.jpg)
D
DAssess, Prevent,
&
Manage Delirium
• Why– Incidence
– Outcomes
• How– CAM ICU, ICDSC
– Nonpharmacologicinterventions
– Pharmacologic interventions
Ely E. JAMA. 2001;286:2703-2710; Bergeron N. Intensive Care Med. 2001;27:859-864; Dubois M. Intensive Care Med. 2001;27:1297-1304; Ely E. Intensive
Care Med. 2001;27:1892-1900; Ely E. JAMA. 2004;291:1753-1762; Pisani M. Am J Respir Crit Care Med. 2009;180:1092-1097; Shehabi Y. Crit Care Med.
2010; 38:2311–2318; Schweickert W. Lancet. 2009;373:1874-1882; Needham D. Arch Phys Med Rehabil. 2010;91:536-542;’ Colombo R. Minerva Anestesiol.
2012;78:1026-1033; Balas M. Crit Care Med. 2013;42:1024-1036; Kamdar B. Crit Care Med. 2013;41:800-809
![Page 39: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/39.jpg)
Inouye SK Arch Intern Med. 2001;161:2467-2473.
Devlin JW Crit Care Med. 2007;35:2721-2724.
Spronk PE Intensive Care Med. 2009;35:1276-1280.
van Eijk MM Crit Care Med. 2009;37:1881-1885.
Delirium is missed in 3 out of 4 cases if a screening
tool is not used.
Missed DeliriousMissedMissed
![Page 40: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/40.jpg)
Hyperactive
2%
Hypoactive
43%
Peterson, et al., J Am Geriatr Soc 2006; 54: 479-84
Mixed
54%
Clinical Subtypes of Delirium
![Page 41: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/41.jpg)
Step 1-Routinely administer valid & reliable delirium screening instruments
• CAM, CAM-ICU, ICDSC, etc.
• Frequency of assessments
• Teaching strategies
• Common errors
![Page 42: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/42.jpg)
Screening: Implementation Strategies
• UTA drama• Case-based scenarios
1
– Before-and-after case studies – Strategy increased usage of the ICDSC by 70% and accuracy of assessment by 54%
• Spot-checking2,3
– Systematic comparison of users with expert raters – Identifies areas for fine tuning education
• Get it into the water– Incorporate delirium into hospital nursing orientation
1. Devlin JW Crit Care. 2008;12(1):R19.2. Pun BT Crit Care Med. 2005;33(6):1199-1205.3. Soja SL Intensive Care Med. 2008;34(7):1263-1268.
![Page 43: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/43.jpg)
Step 2-Consider differential diagnosis & recognize potential for coexistence
• Pain, anxiety, dementia, depression
![Page 44: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/44.jpg)
Step 3- Perform history & physical exam
• History-Baseline status• Medication review
– OTC & ETOH• Physical exam
– VSS, O2 sat, neuro exam, I & O• Laboratory other diagnostic tests
• CBC, electrolytes, renal function test, UA, LFTs, serum drug levels, ABGs, chest X-ray, EKG, cultures
• EEG & CSF rarely helpful
![Page 45: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/45.jpg)
Step 4-Discontinue unnecessary drugs
• Anticholinergics• Anticonvulsants• Antidepressants (anticholinergic only)• Antihistamines (anticholinergic only)• Antiparkinsonian agents
• Antipsychotics
• Barbiturates
• Benzodiazepines
• Chloral hydrate
• H2-blocking agents
• Opioid analgesics (esp. meperidine)
![Page 46: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/46.jpg)
Step 5- Use non-pharmacologic interventions
• Recognize, remove, or reverse of the underlying cause of delirium
• Prevent/correct– Electrolyte disturbances
– Hypoxia
– Infections
– Hemodynamic instability
• Implement fall, aspiration, & safety precautions
![Page 47: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/47.jpg)
Step 5- Use non-pharmacologic interventions• Call bell, close proximity
• DC unnecessary lines/tubes/equipment
• Distraction/activity belts
• Adequate lighting/reduced noise
• Clocks/calendars/pictures
• Avoid physical restraint use– Restraints are indicated only if other
nonrestrictive measures have failed & if behavior puts self or others at risk for harm
• Provide 1:1 care/supervision
![Page 48: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/48.jpg)
Step 5- Use non-pharmacologic interventions
• Provide glasses, hearing aids, &/or other assistive devices
• Favor mobilization/avoid immobilization– Limit the use of tubes & catheters, IVs, &
other devices that “tether” patient
• Assist with ADLS
• Encourage activities that limit anxiety
• Reorient
![Page 49: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/49.jpg)
Reorienting ICU Patients• Before-after observations in 214 ICU patients• Interventions:
– Night environment, music therapy, visual cues (clock)– Reorientation with 5 W’s and 1 H
• Who? Who are you? Who is the nurse/physician?• What? What happened?• Where? Where are you/we?• Why? Why did it happen?• How? How did it happen? And what is the illness progression?
• Result: Delirium incidence reduction – Pre 35% vs. post 22%
Colombo R Minerva Anestesiol. 2012;78:1026-1033.
![Page 50: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/50.jpg)
Step 5- Use non-pharmacologic interventions
Communication-Patient• Provide a way of communicating
needs
• Use reality orientation, repeat information as necessary, explain the situation, environment, & equipment
• ALL BEHAVIOR HAS MEANING!
• Listen to & observe behavior
• Acknowledge feelings & fears
![Page 51: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/51.jpg)
Step 5- Use non-pharmacologic interventions
Communication-Staff• Walking rounds & mental status exam
with off-going care provider
• Delirium screenings at least once a shift
• Conduct multidisciplinary rounds
• Provide for continuity in care
• Rapid response for challenging situations
![Page 52: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/52.jpg)
Step 5- Use non-pharmacologic interventions
Communication-Family• Interview caregivers & family to determine
patients’ baseline behavior & methods to relieve anxiety & depression
• Involve & inform SO of patients change in mental status (provide emotional support)
• Encourage visits by family/friends (may be helpful to call in family 24/7)
![Page 53: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/53.jpg)
Step 5- Use non-pharmacologic interventions
• Nonpharmacologic sleep promotion
![Page 54: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/54.jpg)
Sleep Abnormalities
• More time in light sleep• Less time in deep sleep• More sleep fragmentation
Friese R. Crit Care Med. 2008;36:697-705.
Weinhouse GL, Watson PL. Crit Care Clin. 2009;25:539-549.
There is little evidence that sedatives in the ICU restore
normal sleep
![Page 55: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/55.jpg)
Boosting Sleep Quality
• Optimize environmental strategies
– Day/night variation, reduce night interruptions, noise reduction
• Avoid benzodiazepines (↓ SWS & REM)
• Consider dexmedetomidine (↑ SWS)
• GABA receptor agonists (eg, zolpidem)
• Sedating antidepressants (eg, trazodone) or antipsychotics
• Melatonin
– Pilot: may improve sleep quality of ICU COPD patients
Weinhouse GL, Watson PL. Crit Care Clinics. 2009;25:539-549.
Faulhaber J, et al. Psychopharmacology. 1997;130:285-291.
Shilo L, et al. Chronobiol Int. 2000;17:71-76.
![Page 56: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/56.jpg)
Effect of Common Sedatives & Analgesics on Sleep There is little evidence that administration of sedatives inthe ICU achieves the restorative function of normal sleep
• Benzodiazepines
↑ Stage 2 NREM↓ Slow wave sleep (SWS) and REM
• Propofol
↑ Total sleep time without enhancing REM ↓ SWS
• Analgesics
Abnormal sleep architecture• Dexmedetomidine
↑ SWS
Weinhouse GL, et al. Sleep. 2006;29:707-716.Nelson LE, et al. Anesthesiology. 2003;98:428-436.
![Page 57: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/57.jpg)
Differences in BOLD activities/NREM sleep (fMRI)
Contribution of Sedative-Hypnotic Agents to Delirium Via Modulation of the Sleep Pathway
Sanders RD, Maze M. Can J Anesth. 2011;58:149-156.
![Page 58: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/58.jpg)
E
• Why– Incidence
– Outcomes
• How– Daily safety screen &
success/failure criteria
– Importance of team coordination
– PT/OT driven
EEarly mobility
& exercise
Thomsen G. Crit Care Med. 2008;36:1119-24; Schweickert W. Lancet. 2009;373:1874-82; Pohlman M. Crit Care Med. 2010;38:2089-94.; Needham D. Arch
Phys Med Rehabil. 2010;91:536-42; Morris P. Am J Med Sci. 2011;341:373-7; Hopkins R. Phys Ther. 2012;92:1518-23.; Lord R. Crit Care Med. 2013;41:717-
24; Kayambu G. Crit Care Med. 2013;41:1543-54; Kayambu G. Intensive Care Med. 2015;41:865-74; Miller M. Ann Am Thorac Soc. Epub 2015.
![Page 59: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/59.jpg)
More patients who received early PT+OT were functionally
independent at hospital discharge
1005028211470
0
20
40
60
80
Hospital Days
Proportion of
patients with
functional
independence at
hospital discharge
(%)
Usual Care (n=49)
Early PT+OT (n=55)
p = 0.048
Schweickert, Lancet 2009; 373: 1874-82
![Page 60: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/60.jpg)
F
• Why– Patient & family-centered
care
– Safety
• How– Flexible visiting hours
– Family presence during codes
– Rounding
– Unit design
FFamily
engagement & empowerment
Scheunemann L JAMA 2003; 290: 1166- 1172; Azoulay E Intv Care Med 2003; 29: 1498-1504; McDonagh J Crit Care Med 2004; 32:1484-1488; Azoulay E
Crit Care Med 2004; 32: 1832- 1838; Curtis R Am J Respir Crit Care Med 2005; 171: 844–849; Stapleton R Crit Care Med 2006; 34: 1679- 1685; Norton S Crit
Care Med 2007; 35: 1530- 1535; Lautrette A N Engl J Med 2007; 356: 469- 478; Zier L Crit Care Med 2008; 36: 2341- 2347
![Page 61: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/61.jpg)
ABCDEs: Processes of Care
ABCDE Process Measures
Pre –
ABCDE
(Ntot = 146)
(Nvent = 93)
Post –
ABCDE
(Ntot = 150)
(Nvent = 94)
P
A SAT performed 53% 71% 0.04
B SBT performed 71% 84% 0.03
C Used Benzodiazepines 62% 51% 0.06
D% time CAM-ICU
documented every 8 hoursNA 50% NA
E Out of bed anytime 48% 66% 0.002
Balas MC Crit Care Med 2014;42:1024-36
![Page 62: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/62.jpg)
ABCDE Bundle: Outcomes
Balas MC Crit Care Med 2014;42:1024-36
Outcome
Before
ABCDEs
(n=146)
After
ABCDEs
(n=150)
P
Ventilator-free days (out of 28) 21 24 0.04
Ever delirious 62% 49% 0.02
ICU days with delirium 50% 33% 0.003
Ever comatose 28% 28% 0.91
ICU days with coma 2 2 0.35
ICU mortality 16% 9% 0.07
Hospital mortality (ICU + post-ICU) 20% 11% 0.04
![Page 63: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/63.jpg)
A
D
E
C
F
B
ABCDEF Team Approach
Nurse
Physician
Pharmacist
PT/OT
Respiratory
![Page 64: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/64.jpg)
ABCDEF Road Map(A framework for bedside rounds)
3. How did they get there?Drugs
Assistance needed for Mobility
1. Where is the patient going?Target Pain Level
Target Consciousness Level
Target Mobility Level
2. Where is the patient now?Current Pain & Consciousness Levels
Current Delirium Status
Current Mobility Level
© B
rian Slo
an via Flickr
![Page 65: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/65.jpg)
Improved communication
Families Clinicians
Decreased family anxiety (vs. excluding family)
How do we do it?
1) Prepare family
2) Team rounds as usual
3) Plain language summary
4) Q & A
Does not take longer! (Saves time later?)
Family Engagement on Rounds
Davidson JE, www.nacq.org, 2016
![Page 66: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/66.jpg)
![Page 67: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/67.jpg)
“Most patients return to their primary care
physicians, who frequently don’t know to probe
into the nature of their ICU memories. And if no
one asks, patients might go years before they
admit their experience and seek help — if ever.”
“Their life is terrible, and they often end up back in
the hospital…We need to restructure critical care
to handle the needs of ICU survivors."
"Every day I wake up and I keep
thinking this is the day I'm going to
go back to my old life."
![Page 68: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/68.jpg)
Social Worker
Physician
Nurse
Practitioners
Pharmacist
Psychologist
Case
Manager
Vanderbilt ICU Recovery Center
![Page 69: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/69.jpg)
![Page 70: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/70.jpg)
Aging/Pre-operative studies indicate potential benefits for
physical and cognitive function & hospital outcomes:
Exercise
Strength/ Endurance/ Flexibility
Cognitive
Cognitive stimulating activities/ Computer games
Nutritional
Supplemental nutrition in high-risk patients
“Pre”-habilitation?
O’Doherty Br J Anes 2013;110:697-84
Barnes JAMA Inter Med 2013;173:797-804
Holloway W J Nurs Rsch 2015;37:103-23
Barnes JAMA Inter Med 2013;173:797-804
Gupta Anes Clinics 2016: 34; 2641-50
![Page 71: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/71.jpg)
![Page 72: Non-Pharmacologic Management of Delirium: An ABCDEF … Safety and... · Clinical Subtypes of Delirium. Step 1-Routinely administer valid & reliable delirium screening instruments](https://reader031.vdocuments.us/reader031/viewer/2022022600/5b4060b07f8b9a91078d2fca/html5/thumbnails/72.jpg)
Selected Additional References• Ely E. JAMA. 2001;286:2703-2710 (CAM-ICU)
• Bergeron N. Intensive Care Med. 2001;27:859-864 (ICDSC)
• Dubois M. Intensive Care Med. 2001;27:1297-1304 (Risk Factors)
• Ely E. Intensive Care Med. 2001;27:1892-1900 (LOS and Risk Factors)
• Ely E. JAMA. 2004;291:1753-1762 (Delirium Mortality)
• Pisani M. Am J Respir Crit Care Med. 2009;180:1092-1097 (Delirium Mortality)
• Shehabi Y. Crit Care Med. 2010; 38:2311–2318 (Delirium Mortality)
• Schweickert W. Lancet. 2009;373:1874-1882 (Delirium Reduction)
• Needham D. Arch Phys Med Rehabil. 2010;91:536-542 (Delirium Reduction)
• Colombo R. Minerva Anestesiol. 2012;78:1026-1033 (Delirium Reduction)
• Gusmao-Flores D. Crit Care. 2012;16:R115 (Meta-Analysis of Tools)
• Balas M. Crit Care Med. 2013;42:1024-1036 (Delirium Reduction)
• Kamdar B. Crit Care Med. 2013;41:800-809 (Delirium Reduction)