nih/nasa meeting on space-related health research
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NIH/NASA Meeting on Space-Related Health Research. Henry Rodriguez, Ph.D., M.B.A. Director, Clinical Proteomic Technologies Initiative National Cancer Institute. December 8, 2006. Technology Benefits. Technology Benefits to NCI. Bio-Technology Benefits to NASA. - PowerPoint PPT PresentationTRANSCRIPT
NIH/NASA Meeting onSpace-Related Health Research
Henry Rodriguez, Ph.D., M.B.A.Director, Clinical Proteomic Technologies Initiative
National Cancer Institute
December 8, 2006
Technology BenefitsTechnology Benefits
Bio-Technology Benefits to NASA Technology Benefits to NCI
Miniaturized biochemical analytic laboratories
Bio-Astronautics and Human Exploration
Fabrication of ultra rugged materials and structures
Early detection
Accurate diagnosis
Prevention and improved therapies
Fundamental Technologies in Biomolecular Sensors (NCI-NASA)Fundamental Technologies in Biomolecular Sensors (NCI-NASA)
Workshop (June 1999) on Sensors for Bio-Molecular Signatures
– Richard Klausner, Director NCI; Daniel Goldin, NASA Administrator
– April 2000 MOU, Oct. 2000 launched
Total 6 awards, $13.6M over 4 yrs.– Launching companies & Building
foundation for NCI Alliance for Nanotechnology in Cancer
A. Peptide Functionalized Nanoparticles (Alnis Biosciences Inc., collaboration with UNC Center of Cancer Nanotechnology Excellence)
B. Ultra-bright Near Infrared Fluorophores (possible synergy with Emory and MIT/Harvard Centers of Cancer Nanotechnology Excellence)
C. Molecular Beacons (PI became co-PI of MIT/Harvard Center of Cancer Nanotechnology Excellence)
Nanogel
(carbohydrate or PEG nanoparticle
– targeted drug delivery tool)
A
B
C Molecular Beacons
(enabling live detection of gene expression)
Ultra-bright contrast agent
(deep tissue imaging, > 1 cm)
Object Oriented Data Technology(NCI-NASA/JPL)Object Oriented Data Technology(NCI-NASA/JPL)
OODT’s architecture originally developed for NASA’s planetary data system (PDS) project by JPL
– Open source & Based on open standards: Java, XML, Web Services
– Distributed network that is secure and confidential
EDRN’s Virtual Specimen distributed query system (ERNE) is based on NASA’s OODT
– Existing sites specimen databases maintained locally
– Uses EDRN Common Data Elements (CDEs)
OODT Framework includes:– Name Server; Query Server; Archive
Server; Profile Server; Product Server; Server Manager
Nanowire arrays for early detection (NCI/NASA-Goddard/U. Maryland)Nanowire arrays for early detection (NCI/NASA-Goddard/U. Maryland)
Controlled on-chip synthesis (SiNWs and carbon nanotubes)
Surface mod. readily achieved for affinity-capture material
Ultra-sensitive and fast sensors for electrical, real-time and label-free detection sensing of chemical or biological species (amplicon - femtomolar)
Nucleic acid sequence detection, protein marker detection, and single viral particle detection
Nanomedicine (2006) 1(1), 51-65
Nature Protocols (2006) 1(4), 1711-1724