newsletter 2019 - 01 february 9, 2019 campus...

Newsletter 2019 - 01 February 9, 2019

Annual Report 2018-19 The Multi disciplinary research unit is a flagship scheme of the Department of Health Research sanctioned in January 2014. MRU-TVMC were provided a robust administration with formation of a Governing council 8 formed by senior faculty members and 4 subcommittees namely:- 1.Purchase Committee for monitoring purchases 2.Staff Appointment committee for staff posting and review 3.Finance Committee for accounts, UC and SOE verification 4.Civil Works Committee for Construction and Maintenance

Infrastructure : 1. The MRU-TVMC is located in the first floor of the College Central Library and the modifications carried out under the DHR funds created a state of the art 400 sqm open lab. The project was completed in 3 months within a total expenditure of INR.24,82,541. 2. The MRU has been provided 3 fund releases of INR.1.00, 1.98 and 1.00 crores respectively to a total INR.3,98,91,621. Of this INR 2,98,91,621 has already been utilised. A new set of equipments under the present grant is under purchase and will be installed in the next 2-3 months. We have been provided 5 staff and recurring grants for salaries and contingencies. Research: 2014-2015: 12 concepts were taken up and 6 full proposals were developed in workshop mode conducted by the National Institute of Epidemiology -ICMR, Chennai. 4 of the projects were shortlisted and 3 were approved by the ICMR SPRC for MRU. 2015-2019: SAC (LRAC) was formed as per DHR guidelines. A total of 54 concepts applications were received. 42 full proposals were developed as per DHR guidelines. Of these 39 proposals were placed before the SAC for consideration. The SAC approved 28

Multidisciplinary Research Unit-TVMC �1

Familial Autosomal Myoclonus Epilepsy (FAME/ADCME) Indian gene identified First project under MRU-TVMC is a success story, as the gene has been identified and the publication is awaited. This will be the first such report from India involving122 families with 726 patients. We have published one and 2 more are under preparation.

Sensorineural Deafness novel gene identified Gene identified in 6 patients with Wardenberg Syndrome, is novel and is being reported and survey for more patients has commenced. We have 1 manuscript under preparation.

H a s h i m o t o s T h y r o i d i t i s r a r e metabolite identified Multinodular variant of HT is a unique presentation in our region with specific endocrine and mineral profiles identified. We will be reporting some interesting finding shortly. 126 patients identified and tested. We have published one and 1 more is under preparation.

TVMC Rare Diseases Registry Registries for: ADCME (641) Wardenberg Syndrome (06) Retinoschiesis (04) Spinocebellar Ataxia (43) Parkinsonism (07) NAXOS syndrome (02) MELAS (01) Lamellar Icthyosis (04) Leighs Syndrome (01) Hirschsprung Syndrome (04) Marquios Syndrome (05) Transglutaminase Def (02) Erythrokeratodermia (02) Child Acute Pancreatitis (03)

CAMPUS RESEARCH Multi Disciplinary Research Unit, Tirunelveli Medical College


studies and permitted the studies for commencement of which ✦28 studies have already started. ✦12 new studies are awaiting SAC approvals ✦One Proposal submitted for DST ✦Two Proposals submitted to ICMR ✦One Project sanctioned under ICMR ✦Three Projects sanctioned under NCDIR Completed Projects ✦A study of the genetic determinant of Familial Adult Onset Myoclonic Epilepsy in a Unique community in South Tamilnadu ✦Predicting the occurrence of adverse drug reactions for 5 FLURO URACIL in South Tamilnadu population. ✦Estimation of soluble fms like tyrosine kinase1(sFlt-1) and placental growth factor (PlGF) in determining preeclampsia Ongoing Projects ✦Identification of Novel Genomic Marker as predictor of Sudden Cardiac Death in a specific South Tamilnadu populations ✦Search for a Specific Genomic Marker in predicting the occurrence of severe cutaneous adverse drug reactions for Carbamazepine in South Indian population ✦Genomic Profile of Spino-Cerebellar Ataxia in South Tamilnadu – A study to establish proof of concept for specific drug discovery ✦Genomic Profile of Parkinsons Disease in South Tamilnadu – A study to establish proof of concept for specific drug discovery ✦Identification of Circular RNA CiRS-7 in Breast Cancer and determine its Predictive value as a novel biomarker of breast cancer among women in South Tamilnadu Communities ✦A study of incidence of Carotid artery intimal tear in cases of death due to antemortem hanging ✦Triple negative breast carcinoma – a search for a specific biomarker ✦A comparative study of the levels of serum erythropoietin in patients with diabetic kidney disease and kidney disease of non diabetic etiology ✦Comparison of the Effects of Purified Curcumin and Natural State Turmeric on the Angiogenesis in Zebrafish Embryo ✦Role of Iodine and Selenium in Multi Nodular form of Hashimotos Thyroiditis in our community


Pharmacogenomics Studies Pharmaco-genomic registries for: • Carbamazepine TEN/SJS (14) • 5FU (94) • Phenytoin (03)

Sudden Cardiac Death - autopsy based genomic study S o u t h Ta m i l n a d u w i t h l a r g e indwelling population and high inbreeding. SCD identified in young < 40 years (17-80years). Unique gross changes identified, genomics, TEM, conduction system studies are ongoing.

Departments involved Pathology Pharmacology Community Medicine Forensic Medicine General Medicine Departments involved Pathology Pharmacology Community Medicine Forensic Medicine General Medicine General Surgery Dermatology Neurology Cardiology Nephrology Urology Surgical Oncology Medical Oncology Obstetrics & Gynecology Paediatric Surgery ENT Ophthalmology Chest Medicine


✦Estimation of Glycosaminoglycans / Proteoglycans (GAG/ PG), N-Acetyl-β-D-glucosaminidase (NAG), and Neutrophil gelatinase-associated lipocalin (NGAL) levels in Urine - As early markers of Nephropathy in Diabetes Mellitus Type 2 Patients ✦Circulating free DNA quantification . Is it a prognostic indicator in early stage breast cancers. ✦Development of Population Based Stroke Registry in different regions of India (NCDIR-ICMR) ✦A Study on magnitude and pattern of heart failure – A feasibility study (NCDIR-ICMR) ✦Effects of Natural State Ginger on the Haematopoiesis in Zebrafish Embryo as a proof of concept of a larger clinical role ✦Effect of Life style modification including Yoga on Glycaemic Control among Newly Diagnosed Pre-diabetic Young Adults ✦Study of prevalence of pre-hypertension in adolescent population of Tirunelveli city ✦IL 6 and Alpha-TNF Levels as specific indicators to predict outcome in Dengue Shock Syndrome patients ✦Hospital Based Cancer Registry (NCDIR-ICMR) ✦Role of Urinary Electrophoresis in prognosis of paediatric renal failure ✦A hospital based study of immunological profile of neuropathies of undetermined aetiology ✦Risk of Recurrence of Ovarian Malignancy Algorithm (R-ROMA) – A Multivariate regression model for prediction of tumour residue in ovarian tumours using serial estimation of plasma CA 125 levels and digital SNP quantification ✦Unexplained anemia of elderly and sirtuins SIRT 1 expression – an establishment of proof of concept in search of newer treatment options ✦Tirunelveli Bio Bank Initiative (TBBI) ✦Urinary Metabolomis in Breast Cancer to establish proof of concept for customised machine learning for early and rapid diagnosis of breast cancer. ✦Immunohistochemical expression of estrogen receptors alpha and beta in prostate – as proof of concept for developing newer therapeutic options

Publications Submitted Under Review ✦ Disseminated Tumour Cells in Bone Marrow – Is it an

Independent Prognostic Factor in Breast Cancer. Submitted to Indian J Cytol

✦ Histomorphological Profile of Triple Negative Breast Carcinoma. J Ped Med Oncol

Publications: ✦ Radha Mahadevan et.al. Autosomal dominant

cortical tremor, myoclonus, and epilepsy (ADCME) in a unique south Indian community. Epilepsia,57(3):e56– e59,2016 doi:10.1111/epi.13303

✦ UN Srivatsa, Shantaraman.K et.al. Sudden cardiac death in South India: incidence, risk factors and pathology, Indian Pacing and Electrophysiology Journal 2016, 16 (4), 121-125

✦ Raskin ER, Meenakshi B, S.Kalyanaraman Raw turmeric and pure curcumin: a comparison of embryonic cytotoxicity in zebrafish, Intl.J.Basic Clin Pharmacol. 2017: 6(8);2020-6

✦ B.Meenakshi, Nirmala Devi P, et.al. Profile of c u t a n e o u s a d v e r s e d r u g r e a c t i o n s o f carbamazepine. Intl.J.Basic Clin Pharmacol. 2017: 6(12);2876-2880

✦ J Merla, Shantaraman K, Thyroid Cancer and Nodular Goitre of thyroid. An analysis of patients in rural south Tamilnadu. Thyroid Res and Pract 14(3) 106-108

✦ Sinduja R, Shantaraman K. Histological Profile of Ovarian tumours in rural south Tamilnadu – A 3 year retrospective analysis. Journal of Path and Oncol 4(3) 2017;2(3):49-51

✦ Pabitha.BM, Shantaraman.K, Hashimotos Thyroiditis – A predominantly multi nodular disorder in Costal South India, Annals of Pathology & Laboratory Medicine, Vol5 (3), 2018: p204-08

Manuscript under Preparation

✦ Genomics of Sensori-neural Deafness - A case series (Dr.Suresh Kumar)

✦ Genomics of Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) in a south Indian community (Dr.M.Radha)

✦ Anxiety Disorder is a unique phenotype in Autosomal dominant cortical tremor, myoclonus, and epilepsy (ADCME) in a south Indian community

✦ Multi Nodular Hashimotos Thyroiditis is a unique clinical entity (Dr.B.M.Pabitha Devi)

✦ Time line trends in Breast Cancer – 10 year analysis (Dr.K.Shantaraman)

✦ sflt-1 and plgf in Pre-Eclampsia (Dr PK.Senthil Kumar)

✦ E Cadherin & CK5/6 in TNBC (Dr.K.Swaminathan) ✦ AMCAR in Prostate Carcinoma (Dr. S.Vasuki) ✦ Effect of Phenyl Hydrazine on Zebrafish Embryos

(Dr. R.Raskin Erusan) ✦ Adverse Drug Reaction in 5FU treated patients

(Dr.B.Meenakshi) ✦ Time line trend in Sudden Cardiac Deaths

(Dr.K.Shantaraman)



Training 1.August 2015: Basic Course Workshop in Research Methodology & Hands on Training in Framing a Research Question. Participants : Faculty TVMC,Total number of Participants 33 2.September 2015: Basic Course Workshop in Research Methodology for UG students. Participants : II-Final MBBS students,Total number of Participants 6 3.September 2016: Basic Course Workshop in Research Methodology Participants : Faculty TVMC,Total number of Participants 30 4.September 2016: Basic Course Workshop in Research Methodology for UG students. Participants : II-Final MBBS students,Total number of Participants 72 5.July 2017: Clinical Genomics Workshop Participants : 103. Resource Persons: Dr Sridhar Sivasubbu , Dr Vinod Scaria, Dr Sivaprakash; CSIR – IGIB New Delhi. Demonstration of HiSeq Machine and NGS Technology 6.August 2017: Basic Course Workshop in Research Methodology for Post Graduates. Participants : PG students TVMC,Total number of Participants 100 7.November 2017: 2nd Proposal Development Workshop Director NIE presided, Participants : 22; Proposals Developed : 17 (MRHRU) 2 (MRU) 8.Basic Course Workshop on Biostatistics Participants : 45, Resource Persons: Dr R.Ramakrishnan , & team

Translation of Research We have commenced a population based research for identifying patients with ADCME or its forme-frustae for diagnosis of the gene defect. A counselling and guidance for this patients have been established through the network of neurologists working in this project.

Acknowledgments: We thank the Department of Health Research, Govt of India for the grants aid and support in our journey since 2014.


Short Term Student Research 1. T h e s t u d e n t s o f T V M C a r e

encouraged to participate in short term research in the campus and many of these projects have been s u b m i t t e d u n d e r I C M R - S T S program for funding.

2. We h a v e s h o w n s i g n i fi c a n t progress in this direction

3. October 2017:Integrat ion of Research training in UG curriculum – Weekly Saturday 2 hours devoted to Lectures, Hands on Training and smal l group d iscuss ions on research methods and advances in medical science

newsletter 2019 - 01 february 9, 2019 campus...

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