neutriderm moisturising lotion reference (disodium lauriminodipropionate tocopheryl phosphates...
TRANSCRIPT
-
8/14/2019 Neutriderm Moisturising Lotion Reference (Disodium Lauriminodipropionate Tocopheryl Phosphates potent new ant
1/2
MoisturisingLotion
Vitamin E
The deleterious effects of sun exposure relating to erythema and freeradical induced aging are well documented. Moreover, recent studies
have shown that brief exposure to UV rays during normal everyday
routine activities can be cumulative and produce the above effects
over time. Similarly, the overuse of cosmetics can cause sub clinical
erythema, which can also be cumulative.
The daily use of products that inhibit the above deleterious skin effects
is needed for moisture balance, to mitigate free radical-induced
premature skin aging, and to promote youthful healthy skin is anecessity for most all skin types. A cream containing 3% wt/wt vitamin
E phosphate (disodium lauriminodipropionate tocopheryl
phosphates), a new potent form of vitamin E, can readily be used to
prevent erythema and restore skin as a before and after sun exposure
product.
For optimal coverage the formulation contains the above in a light
elegant cosmetic base with INCI-registered esters to promotemoisture balance and emolliency. In addition, the cream reduces
redness due to acne. Skin studies have shown that in this base the
vitamin E phosphate exhibits excellent distribution into the skin
compared with an equivalent amount of vitamin E acetate. Clinical
studies have shown that vitamin E phosphate at levels of 1% to 3%
active is a more effective anti-inflammatory compared with aloe,
vitamin E acetate, and a topical steroid. The results of a human repeat
insult patch test (HRIPT) on humans show no cumulative irritation
and/or sensitization, and the cream is well tolerated for frequent daily
use on skin.
Otto Mills, PhD, Robert Wood Johnson Medical School, Doylestown, PA, UnitedStates; Robert Verdicchio, PhD, Verdi Enterprises, Succasunna, NJ, United States; Journal of American Academy ofDermatology. March 2005 (Vol. 52, Issue 3, Suppliment, Page P-85)
Anti-inflammatory skin creamwith Vitamin E Phosphate
AfterBefore
-
8/14/2019 Neutriderm Moisturising Lotion Reference (Disodium Lauriminodipropionate Tocopheryl Phosphates potent new ant
2/2
The beneficial use of vitamins in general & specifically vitamin E, continues to be an active
area in dermatology & cosmetic science. It is clear that vitamin E, especially in the form of
-tocopherol, is a potent antioxidant and is widely used by the body to protect lipids in cell
membranes from oxidative damage. However, the role of vitamin E in skin is much less
clear, both in the understanding of its intrinsic role as well as clearly demonstrating its
clinically relevant, in vivo benefits.
-Tocopherol is stored in the liver & adipose tissue. In the liver it is bound and transferred
by a specific cytosolic protein, -tocopherol transfer protein (?TTP). When circulated
through plasma, tocopherol is transported by several forms of lipoproteins including very
lowdensity lipoproteins (VLDL) & high density lipoproteins (HDL). It is believed that most-tocopherol is delivered through HDLs to cells for use in the membrane or within the cell. It
is not unreasonable to assume that when delivered topically, - tocopherol needs to
associate with a transport protein to gain access to the dermis, especially the fibroblasts,
unless some other delivery vehicle is provided in the formulation.
Another significant formulation challenge is to keep -
tocopherol stable until use. The most common approach is
to use the ester -tocopherol acetate. Although the ester is
more stable than -tocopherol, it has a different efficacyprofile. For instance, it has been shown that -TTP binds -
tocopherol to an extent more than 50 times greater than -
tocopherol acetate.
A second approach to vitamin and drug stabilization is
phosphorylation. Phosphorylation is the transformation of
an alcohol to a phosphate ester through transfer of a
phosphoryl group (-PO3H2). Adenosine triphosphate
(ATP) is the most common endogenous phosphorylatingagent. It has been shown that phosphorylated vitamin C is
accumulated into cells as vitamin C. Work in our
laboratories has begun to develop evidence for the
presence of phosphorylated - tocopherol in the human
body. For this reason, we believe that phosphorylation is a
better route to formulation stabilization & that it allows a
better opportunity for in vivo efficacy through an
endogenous form that can be activated by phosphate ester
cleavage.
UAS Pharmaceuticals Pty LtdP.O. Box 802 Castle Hill, NSW 1765 Australiawww.neutriderm.com.au AUS TRALI ANMADE & OWNED
By: Mark E. Rerek, International Speciality Products; Otto H. Mills, Robert Wood Johnson Medical School; Robert Verdicchio andSimon West, Vital Personal Care Specialties
Disodium Lauriminodipropionate Tocopheryl Phosphates:
Potent New Anti-Inflammatory