Negative selection and adaptive duplication, not sensory exchange, explain chemosensory gene repertoires in noctilionoid bats

Liliana M. Dávalos, Elizabeth R. Dumont, Stephen Rossiter, Sharlene Santana, Karen Sears, & Laurel R. Yohe

International Bat Research Congress, Durban4 August 2016

Sensory tissues are expensive

• For neurons• Maintaining function,

even at rest, is energetically expensive

• Excess functional capacity has increased energetic costs

• Reduction may relate to high energetic costs

Niven & Laughlin 2008 J. Exp. Biol.

Sensory exchange hypothesis Gilad et al. 2004 PLoS Biol.

Trichromatic visionExcess pseudogenes

Statement 2 V. Wiebe and S. Pääbo retract their names from the publication since they are of the opinion that the primary data do not support the conclusions presented.

Comparative evidence for trade-off Hypothesis with sensory systems

An alternative: grade shifts Garland 2014 Curr. Biol.

The bat chemosensory system In a phyllostomid

Chemosensory trade-off? Hayden et al. 2014 Mol. Biol. Evol.

Mo

lecular Biolo

gy and Evo

lution

Volum

e 31 • Num

ber 10 • October 2014

Published on behalf of the Society for Molecular Biology and Evolution

Joshua Akey, University of Washington, USADoris Bachtrog, University of California, Berkeley, USAMiriam Barlow, University of California, Merced, USARobin Bush, University of California, Irvine, USADouglas L. Crawford, University of Miami, USACharles F. Delwiche, University of Maryland, College Park, USAJuliette de Meaux, Universität Münster, GermanyAnna Di Rienzo,* University of Chicago, USAJoel Dudley, Mt. Sinai School of Medicine, USADaniel Falush, Max Planck Evolutionary Anthropology, GermanyBrandon Gaut,* University of California, Irvine, USATakashi Gojobori, National Institute of Genetics, JapanManolo Gouy,* Université Lyon, FranceXun Gu, Iowa State University, USAMatthew Hahn, Indiana University, USAS. Blair Hedges,* The Pennsylvania State University, USARyan D. Hernandez, University of California, San Francisco, USAAsger Hobolth, University of Aarhus, DenmarkBarbara Holland,* University of Tasmania, AustraliaHideki Innan, School of Advanced Sciences, JapanDavid M. Irwin, University of Toronto, CanadaLars Jermiin, CSIRO, AustraliaYuseob Kim, Ewha Womans University, KoreaThomas Leitner,** Los Alamos National Laboratory, USAJohn Logsdon, University of Iowa, USAJohn H. McDonald, University of Delaware, USAJames McInerney, National University of Ireland, MaynoothAoife McLysaght, Trinity College, IrelandMichael Nachman, University of Arizona, USAStuart Newfeld, Arizona State University, USARasmus Nielsen, University of California, Berkeley, USAJohn Novembre, University of Chicago, Chicago, USAKatja Nowick, Universität Leipzig, GermanyTodd H. Oakley, University of California, Santa Barbara, USACsaba Pal, Institute of Biochemistry, HungaryJohn Parsch, University of Munich, Germany

Helen Piontkivska, Kent State University, USASergei Kosakovsky Pond,** University of California, San Diego, USATal Pupko, Tel Aviv University, IsraelMichael Purugganan, New York University, USAOliver Pybus, University of Oxford, UKSohini Ramachandran, Brown University, USAEduardo Rocha,* Institut Pasteur, FranceAndrew J. Roger,* Dalhousie University, CanadaClaudia Russo, Federal University of Rio De Janeiro, BrazilIlya Ruvinsky,** University of Chicago, USANaruya Saitou, National Institute of Genetics, JapanYoko Satta, Graduate University of Advanced Studies, JapanBeth Shapiro, The Pennsylvania State University, USAAnne C. Stone,* Arizona State University, USABing Su, Kunming Institute of Zoology, ChinaWillie J. Swanson, University of Washington, USANaoki Takebayashi, University of Alaska, Fairbanks, USANaoko Takezaki,* Kagawa University, JapanKoichiro Tamura, Tokyo Metropolitan University, JapanEmma Teeling, University College Dublin, IrelandJeffrey Thorne,* North Carolina State University, USASarah Tishkoff, University of Maryland, College Park, USAJohn True, Stony Brook University, USANicholas Vidal, Museum National d’Histoire Naturelle, FranceArndt von Haeseler,* Center for Integrative Bioinformatics, AustriaClaus Wilke,** University of Texas, USAPatricia Wittkopp, University of Michigan, USAGregory Wray, Duke University, USAStephen Wright, University of Toronto, CanadaShizhong Xu, University of California, Riverside, USAMeredith Yeager, National Cancer Institute, USAGeorge Zhang,* University of Michigan, USA

Cover Art Caption: Gain in olfactory receptor gene subfamilies is associated with adaptation to a frugivorous lifestyle. Image depicts a New World Watson’s fruit bat (Dermanura watsoni) and an OR phylogenetic tree

across bat species. Cover art provided by Liliana M. Dávalos and photo by Sébastien Puechmaille (Volume 31, pp. 917–927).

ASSOCIATE EDITORS

* Also a Senior Editor ** Guest Editor

Published by Oxford University Press 2014.

Volume 31 • Number 10 • October 2014

Print ISSN 0737-4038Online ISSN 1537-1719

www.mbe.oxfordjournals.org

Society for Molecular Biology and Evolution

Molecular BBiology and EEvolution

• A tool for inferring large Bayesian phylogenies

• Experimental models fit the data much better

• Genetic diversity in captive giant pandas

• Mosses mitochondrial genomes are frozen in time

• P450 is a genetic component for termite societies

mbe_31_10_Cover.indd 1mbe_31_10_Cover.indd 1 16-09-2014 12:21:2016-09-2014 12:21:20

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●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●●

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insects blood small verts nectar soft fruits figs Old World fruit

Take-home

• Lots more work needed to get complete inventories

• Molecular evolution analyses show clear patterns• Conservation of

V1Rs• Expansion of certain

OR subfamiliesPhoto by S. Puechmaille

Thanks!