Nanomanufacturing & MedTech Research at UMass Lowell

MassMEDICApril 10, 2007

Nanomanufacturing Programs at UMass Lowell

• NSF NSEC Center for High-Rate Nanomanufacturing. 9/04: $12.4MM

UMass Lowell ,Northeastern and UNH

• Nanomanufacturing Center of Excellence 12/04: John Adams Innovation Institute $5MM to UMass Lowell.

• New Nano/Bio/Manufacturing Building

4/07 Gov. Patrick commits

$25 MM Cash + $16 MM Bond for

Commercialization of Nanotechnology: Nanomanufacturing is a Vital Component

Flexible Electronics, Sensors, Implants

Biosensors (radiation, cancer, anthrax, insulin...)

New Reinforced Materials

Nano Capsule for Drug Delivery Drugs by

Design

NanoManufacturing

Research

New Fabrics

The Path to Commercialization

Production

NanoscienceScientific discovery, basic theory, test hypotheses

Nanomanufacturing Science

Process science (models, discovery of process methods, reliability

theory, enabling tools) Fundamental science focused on

manufacturing

Nanomanufacturing Center of

Excellence

Product Prototypes, Scalable processes

Specific product process development, “prototype” products

Process Scale upShort production runs, debug

scale up

• Materials suppliers• Process equipment manufacturers• On-line measurement equipment• Products (bio, electronic, automotive, chemical, aerospace…)

NSF NSECCenter for High Rate Nanomanufacturing

Nanomanufacturing at CHN

Biosensors

Memory devices

TemplatesHigh rate

High volume Reliability

Manipulation of billions of atoms and nanoparticles

Informed public and workforce

Environmentally benign processes

CHN

CHN Vision: Guided Self Assembly

Will provide the tools to manufacture a wide range of nanoscale products

Nanomanufacturing Through High-rate/High-volume Templates for Guided Self-Assembly of Nanoelements

microinjection molding machine

Injection Molder

Nanotemplates as tooling surface in high rate process

Nanopatterned Surfaces

Biosensors (radiation, cancer,

anthrax, etc.)+ IgG

NCOE Vision: Capitalize on Polymer Advantages

• Lightweight• Flexible• Biologically compatible• Easily adapted for high

rate processes

Electrospun NanofibersDr. Mead, Plastics Engineering

Inner core •provide mechanical or electrical properties

Outer core•highly absorbent material

Selectively permeable materials•highly breathable•impermeable to liquid water•stretchable•novel textiles•tissue scaffolding

Controlled Patterning of NanoFibersDr. Chen, Mechanical Engineering

High voltagepower supply

Syringe withploymer solution

Shi

ft a

nd s

prea

d of

the

spun

fib

ers

on ta

rget

Rotated discelectrode at syringe

Electrospinning can be used to create submicron diameter fibers with high surface area and fabrics with fine porosity

Greater functionality (and information content) can be achieved through controlled patterns, rather than random mats

1 bilayer

5 bilayers

10 bilayers

Continuous TiO2 on Polyacrylonitrile

TiO2 particles on Functionalized Polyacrylonitrile

Coated Materials include•Polyelectrolytes•Metal Oxides•Conjugated Polymers

Applications include•Photovoltaic Cells•Sensors•Catalysts•Water purification

Layered Materials on NanofibersDr. Kumar, Physics Department

PAHH-PURETCA Fiber

Nanomultilayer CoextrusionDrs. Barry & Mead, Plastics Engineering

• Utilize coextrusion process – Two polymers of dissimilar structure and properties to be combined– Nanolayer laminates with hundreds or thousands of layers– No nanoscale dimensions on tooling– Conventional coextrusion facilities can be used except layer-

multiplying elements

1st3rd

2nd

2nd

4th

Single Screw Extruder

Layer Multiplying

Element (LME)

Feedblock

Single Screw Extruder

Layer Multiplying

Element (LME)

Feedblock

NanocompositesDrs. Barry , McCarthy & Mead, Plastics Engineering

Nanocomposites •High performance properties•Issue is repeatable dispersion in commercially viable process•Study effect of process conditions/material on dispersion

•Nanoclay•Nanoparticulates (alumina, silica, carbon black)

Improved•Barrier properties•Mechanical properties•Flame retardance•Thermal properties

Self-assembled monolayers (SAMs), including alkanethiols adsorbed on gold surfaces

• Thiophene-terminated alkanethiols have been sythesized and used to coat gold nanoparticles.• Organic vapor sensors have been fabricated from the monolayer protected gold nanoparticle films.

0

20

40

60

80

100

0 50000 100000 150000 200000

Rel

ativ

e ch

ange

of

resi

stan

ce (

R/R

o) [%

]

Vapor Concentration (ppm)

TolueneChloroform

Hexane

Ethanol

Change of Resistance vs Organic Vapor Concentration for Films Comprised of Gold Nanoparticles Protected by 12-(3-thienyl)dodecanethiol

*H. Ahn, A. Chandekar, C. Sung and J.E. Whitten, Chemistry of Materials, vol. 16, p. 3274 (2004).

Surface Functionalization and CharacterizationDr. Whitten; Chemistry

Nanospherical Gold Delivery SystemsDr. Braunhut, Biology

“Non-invasive product that kills cancer using localized lethal heat with negligible damage to healthy tissues”

In conjunction with Triton Biosystems of Chelmsford, MA

• Targeted/controlled delivery

Self-assembly in water Optional removal of core

• Core-shell structure

• Shell can be crosslinked

• Core can be selectively removed

• Shell and/or core can be functionalized selectively

Self-assembly of Polymer MicellesBiodegradable Hollow Nanospheres for

Drug DeliveryStephen P. McCarthy, Plastics Engineering, 978.934.3417

Biodegradable Hollow Nanospheres for Drug Delivery

Stephen P. McCarthy, Plastics Engineering, 978.934.3417

Self-assembly in water

Optional removal of core

Self Assembly of Polymer Micelles

•Core-shell structure

• Shell can be crosslinked

• Core can be selectively removed

• Shell and/or core can be functionalized selectively

Typical curve with expected value of cac

RhRH

mica mica mica

Well-defined spherical

nanoparticles observed

Atomic Force Microscopy Analysis of

Nanoparticles

Transdermal Delivery of Insulin with Cationic Shell-xlinked Hollow

Nanospheres in Hyperglycemic Rats

Glucose tolerance test in normal rats

0

50

100

150

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250

300

350

400

450

0 20 40 60 80 100 120 140

Time, min

Glu

co

se

, mg

/dl

Glucose alone

Insulin in cationic nanospheres

Highlights of Results

Encapsulation of nutrients, such as Vitamin E

Oral and transdermal delivery of insulin

Transdermal delivery of antiinflammatory agents

Encapsulation of hydrophobic and hydrophilic substances

Antibacterial properties of cationic nanospheres

Biodegradable Hollow Nanospheres for Drug Delivery

Stephen P. McCarthy, Plastics Engineering, 978.934.3417

Massachusetts Medical

Device Development Center (M2D2)

UMASS Lowell & UMass Worcester

Connect the resources of the University of Massachusetts

to Medical Device firms within Massachusetts

M2D2 Mission

M2D2M2D2

EducationEducation

ProductProductRealizationRealizationProcessProcess

NetworkNetwork

BusinessBusinessRealizationRealizationProcessProcess

Medical Device Industry Critical to Massachusetts’ Future

What was Once An Economic Engine

Medical Device Employment Trends

75%

80%

85%

90%

95%

100%

105%

110%

115%

120%

2000 2001 2002 2003 2004 2005

CA

MA

MN

NC

US

Is Now Declining Compared to Others

Source: Economy.com 4 digit NAICS code 3391 Employment: Medical Equipment & Supplies Manufacturing

With M2D2 They Can Reach Across

M2D2M2D2

Proof of ConceptBusiness Plan

Team

Inventors

IdeasMock-Ups

Investors

MarketsProducts

Product/Business Realization Process Creates 8-11

Companies/YearSeed Fund

(3-8 mos)Prototyp

e & AnimalTrials

(12 mos)

Human Trials(18-24 mos)

Screening

(2-4 mos)

UnqualifiedLeads

Markets & Investors

Milestone

Competitive Selection

Seed funding obtained & Business Plan

Prototype demonstrated in Animals/Cadavers

FDA Regulatory Submission

8-11300 45 22 11300/yr

15%

50%

50%

75%

17-24 months

M2D2 Helps Entrepreneurs Find Funds

• SBIR grants

• STTR grants

• John Adams Innovation Institute

• Angel investors

Seed Funding process requires 3-8 months Depending on concept quality & funding source

Multiple Companies Already Benefiting

• Perfusion Technology

UMass Lowell Incubator

( SBIR, April 2006, August 2006)

Ultrasound Enabled Drug

Delivery To the Brain

Multiple Companies Already Benefiting

• Spire Biomedical Bedford, MA

(SBIR, December 2006)

Novel Dialysis Catheter

Multiple Companies Already Benefiting

• Vista ScientificAndover, MA

(STTR, April 2007)

Nanosphere-Antibiotic Corneal Contact Lens Delivery System

Multiple Companies Already Benefiting

• VasoTechWorcester, MA

(FastTrack, April 2007)

Biodegradable Drug Eluting Stent

Multiple Companies Already Benefiting

• BosteQBoston, MA

(STTR April 2007)

Vibrotactile Tilt Feedback

for Balance Rehabilitation

and Elderly Fall Reduction

M2D2 Steering Committee• Hooks Johnston, Chair• (SVP, Smith & Nephew, Retired)• Daniel Baril, President & CEO, Baril Die Company• John Brooks III, General Partner, Prism Venture Partners• Thomas Chmura, Vice President for Economic Development, University of

Massachusetts President’s Office• Paul Fenton, President, Axya Medical• Robert Halpin, President & CEO, MVEDC, Inc.• John Konsin, Executive Vice President & General Manager, Accellent

Endoscopy• Peter Litman, Vice President for Business Development and Marketing,

Anika Therapeutics, Inc.• Stephen McCarthy, Co-Director, M2D2, University of Massachusetts Lowell• Sheila Noone, Co-Director, M2D2, University of Massachusetts Worcester• Richard Packer, President & CEO, Zoll Medical Corporation• Thomas Sommer, President, MassMEDIC• Josh Tolkoff, Managing Director, Ironwood Equity Fund LP• Edward C. Williams III, Partner, Brook Venture Partners

Big Things from Small Science

• Continuing the tradition of manufacturing excellence in Lowell region– Education– Research– Service to industry and the

community

• Sustainable economic development for the US