mycotoxins contamination of animal feed
TRANSCRIPT
Mycotoxins contamination of animal feed
Francois StepmanNovember 18th- 20th 2015 Berlin
16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development
courtesy of Prof. dr. Siska CROUBELSDepartment of Pharmacology, Toxicology and Biochemistry
Faculty of Veterinary Medicine – Ghent University
www.mytox.be
• Introduction• AflaNet to be funded by German BLE• Influencing EC funded research
Outline of the presentation
01-02 October 2014. Berlin, Germany. Federal Ministry for Economic Development and Cooperation (BMZ). Expert meeting on Food Safety for Nutrition Security discussing aflatoxin.
4
Mycotoxins:
• Introduction• Effects in animals• Effects on intestinal barrier function• Consequences of impaired barrier function• Transfer of residues to animal food products
Effects on animal health
Pig reduced performancereduced feed utilization and efficiencyimpaired fertilityskin lesions
Poultry reduced performance“fatty liver” syndromedecreased egg productionpoor carcass quality
Cattle reduced milk yieldimpaired fertilitymastitisketonuria
Horse neurotoxic syndrome
Subclinical doses: immunosuppressive effects
CLINICAL EFFECTS IN ANIMALS
dr. J. Leus
www.mycotoxins.infowww.thepoultrysite.com
Dependent on
- type and dose
- duration of exposure
- species, gender, age, health status
- synergistic effects (single vs. multiple toxins)
www.efsa.eu.intwww.knowmycotoxins.com
www.thepoultrysite.comwww.mycotoxins.info
CLINICAL EFFECTS IN ANIMALS
EFFECTS OF MYCOTOXINS
www.mycotoxins.info
EFFECTS OF MYCOTOXINS
www.mycotoxins.info
EFFECTS OF MYCOTOXINS
www.mycotoxins.info
Small intestine:• Absorption of water and nutrients• Dynamic barrier
GASTROINTESTINAL TRACT: FIRST TARGET FOR MYCOTOXINS
MYCOTOXINS IMPAIR INTESTINAL BARRIER
Altered intestinal functions:CONSEQUENCES?
Enhanced susceptibility to enteric infections?
Altered digestion and absorption of nutrients?
Altered absorption of veterinary drugs and feed additives?
Toxins, 2014
TRANSFER OF MYCOTOXINS TO ANIMAL FOOD PRODUCTS
•Feed contamination: 1 mycotoxin << multimycotoxin (1+1 = sometimes 3)
•Effect of high contamination levels of the feed (rare) on animal health is mostly known, however the effects of low to moderate contamination levels (frequently occurring) is less well-known
•Even low contamination levels (< max. EU guidance levels) can have a negative effect on poultry, pigs, …
•Economic impact of mycotoxins ≠ animals with clinical mycotoxicosis
TAKE-HOME MESSAGES
•Negative impact on the intestinal morphology and function: -enhanced susceptibility for infectious diseases-altered digestion and absorption of nutrients-altered absorption of veterinary drugs
•Modulate the immune response
•(Partial) hydrolysis of masked DON and release of native DON in poultry and pigs
•Limited transfer of residues to animal food products, except e.g. for aflatoxin B1 (M1) to milk and ochratoxin A to kidney tissue
TAKE-HOME MESSAGES
AflaNETNetworking on aflatoxin reduction in the food value chain
Application at BLE German Federal Office for Agriculture and Food
Joint cooperation in the area of combating Aflatoxin contamination
Department of Safety and Quality of Cereals
16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development
01.05.23 17
Associated partners
• JKI Federal Research Centre for Cultivated Plants • FLI Federal Research Institute for Animal Health• PAEPARD Platform for African – European Partnership• EAFF Eastern Africa Farmers Federation• KALRO Kenya Agricultural and Livestock Research Organization • ILRI International Livestock Research Institute• AflaStop Project funded by the ACDI/VOCA organization • GIZ GmbH Deutsche Gesellschaft für Internationale Zusammenarbeit
MRI – Federal Research Institute of Nutrition and Food
The goal is to initiate a long-lasting scientific network between African and German
partners by working out the possibilities to reduce aflatoxins in the food value chain
via close contacts.
Project leader MRI Federal Research Institute of Nutrition and FoodDr. Christine Schwake-Anduschus
Budget 173.312 – Duration 12/2015 – 12/2016
16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development
Workpackages
01.05.23 18MRI – Federal Research Institute of Nutrition and Food
WP 2 Applicability of rapid test kits for aflatoxin detection
WP 3Aflatoxin M1 development:Knowledge about the ratio B1 feed/M1milk
WP 4Aflatoxin B1 inactivation ofbiosynthesis at the molecular level
WP 6 dissemination of project results, Networking East-Africa and Kenya-Germany
Prospects of Minimization of Aflatoxin in Feed and Food in KenyaLong lasting Cooperation of
German Federal Institutes and Kenyan/ East-African Key Actors
Installation of sustainable relationships
WP 1Liasion officer in KenyaExcursion andExperts survey on siteConference and exchangewith scientists and active groups in Kenya, e.g. EAFF, KALRO, ILRI, PACA, MRI, JKI, FLI
Germany Kenya
WP 5 Capacity building: visits of Kenyan scientists at MRI
16th annual meeting of the Inter-Agency Donor Group (IADG) on pro-poor livestock research and development
Please contact the project leader
Dr. Christine Schwake-AnduschusMax Rubner-Institut
Department of Safety and Quality of CerealsSchuetzenberg 12
32756 Detmold, GermanyTel 0049 (0) 5231 741 132
www.mri.bund.de
Advisory participation is appreciated !
01.05.23 19MRI – Federal Research Institute of Nutrition and Food
1. mobile phone apps on awareness creation and moisture control;
2. the use of binders in feed to reduce waste and give an incentive to farmers for contaminated crops which should be destroyed;
3. biological control measures: in particular the use of antagonistic bio control agents in addition to the bio control agent ‘aflasafe™’. The use of Trichoderma strains or extracts as bio-fertilizer or bioagents also out-competes Aspergius flavius in the soil.
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