NUCLEAR MEDICINE WEEK 2006

SSSIHMS.PSN

MOLECULAR IMAGING

BY DR.V.SIVASUBRAMANIYAN, Dept.of Nuclear Medicine

W H A T I S .. D E F I N I T I O N

Molecular Imaging defined as IN-VIVO

characterisation and imaging of BIOLOGICAL

PROCESSES at the Cellular and Molecular

with TARGETTED IMAING TECHNIQUES.

H O W I S I T D I F F E R E N T

CONVENTIONAL I M A G I N G - EFFECT OF A PATHOLOGICAL PROCESS IS DEPICTED

MOLECULAR IMAGING – DEPICTS OR DELINEATE S THE PATHOLOICAL PROCESS CAUSING THE DISEASE

B A S I C T O O L ..

M O L E C U L A R P R O B E S

H I G H A F F I N I T Y – 2 T Y P E S

L.M.W – RECEPTOR LIGANDS ENZYME SUBSTRATES H.M.W- MONOCLONAL Ab RECOMBINENT PROTEINS

C R I T I C A L I S S U E S

C E L L I N T E R N A L I S A T I O N

A DE Q U A T E C O N C E N T R A T I O N

R E T E N T I O N F O R L O N G E R

M E T H O D S O F I M A G I N G

N U C L E A R I M A G I N G

M A G N E T I C R E S O N A N C E

O P T I C A L I M A G I N G

N U C L E A R S T U D I E S

Na I SYMPORTER TRAPPING – I 131

THYROID / LACTATING BREAST/ GASTRIC MUCOSA

FDG PET

HSV1- THYMIDINE KINASE

M. R . I

MONOCRYSTALLINE IRON OXIDE NANO-PARTICLES

SECOND REPORTER SYSTEM

ENZYMATIC HYDROLYSIS

O P T I C A L I M A G I N G

NEAR INFRA RED FLUROSCENCE IMAGING

BIO-LUMINESCENT PROTEINS