CATALINA SALAZAR DUQUE

MOLECULAR BIOLOGY

3RD SEMESTER

MEDICINE

UNIVERDAD PONTIFICIA BOLIVARIANA

MEDELLÍN

2015

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INTRODUCTION We all know how important DNA is in the human body. It

has the entire genetic information of a person, since what

sex are they going to be, until the sex preferences they’re

going to have, their likes or dislikes and even their entire

personality.

DNA is everything on a person, the genomic information

that it has, has to be with everything in the humans body

and that’s why it is so important.

In the DNA we could find different information, and

in relation with medicine is important because it

manages the information of the internal human

body so depending on it, humans develop different

kind of characteristics, even diseases related to

some specific information.

But also it lead us to use it as a tool to know about

this specific characteristics and information for us

to learn what to do with it and how treat it.

Mayor European mouse study reveals the role of genes in diseases

Mice’s genes are 90% similar to

humans ones, so the European Mouse

Disease Clinic made an investigation

about 320 of their genes to look for

some type of relations or explanations

to some human diseases.

Mayor European mouse study reveals the role of genes in

diseasesThe EUMODIC made almost a 150 different

tests to the mice. Over an 80% of the

evaluations made, leaded them to a clue to

what the missing gene’s role might be.

In order to do this they divided the mice in groups that had a single gene removed to analyze them between the tests.

Mayor European mouse study reveals the role of genes in

diseases

One of the genes that they

found it’s called Elmod1.

They found that it is related

to glucose levels, so if the

gene was missing, the

mouse presented lower

glucose levels.

Mayor European mouse study reveals the role of genes in

diseases

EUMODIC was the first place to create a mouse

database of their genes functions but now this

is being implanted in different places of mouse

studies because they are trying to find what the

function of mice 20.000 genes, are.

Mayor European mouse study reveals the role of genes in

diseases

I think this is a really important step for

everything related to humans health.

From this study and the ones that are

coming, they will be able to find which

genes is related to some things presented

in a person and what way do they work so

depending on that they’ll analyze and

create things to prevent some pathologies,

to improve people’s lifestyle and health.

Modify DNA building blocks are Cancer’s Achilles heel

Ludwig cancer researchers

discovered that DNA-recycling

mechanism can be turn against

certain cancer cells

Cell are always trying to thrift when they are synthesizing new DNA, so that’s why they to a recycling process to use what the past DNA synthetized didn’t use.

Modify DNA building blocks are Cancer’s Achilles heel

Normal cell have a highly selective

mechanism to ensure that nucleosides

don’t carry any unwanted chemical

changes, but the cancerous cells aren’t

that selective.

Ludwig researchers found that maybe

they will be able to attack this cells by

modifying the nucleosides for killing them.

They are trying to implement this as a strategy to fight with cancer.

Modify DNA building blocks are Cancer’s Achilles heel

In the DNA there’s a part that is

often chemically modify.

If this modification is in the wrong

place, the cells can be damaged

and can be killed.

In this investigation they are trying to find how

cells prevent that the modified part of the DNA,

ends up in the wrong place, so they will try to get

into the process, change it and using it against

cancer cells as an anti-cancer agent!!!!!!!

Modify DNA building blocks are Cancer’s Achilles heel

Modify DNA building blocks are Cancer’s Achilles heel

I found this investigation really important

and amazing for the cancer treatment

because basically it will help humans

with this disease to get done with it by

killing the cancerous cells, and help

them to don’t have anymore damage.

Both news are medically important

because they are trying to find some

ways to prevent some human illness, by

investigating how the cells and the

components of them work, so this will

lead them to create some processes or

treatments to help the affections that

they have

Cancers figure among the leading

causes of morbidity and mortality

worldwide, and other diseases are

cause of deaths too, so if the results of

these investigations work out it would

be a BIG step for medicine and it would

be easier to treat and save people’s

life.

From this, more investigations will

begin and more things will be

invented, so humans health will

have the possibility to get better,

more and more, everyday.

This studies don’t have a highly

selection because they work o

DNA’s, so this could be apply to

every single person who needs it

and has the possibility to afford it.

BIBLIOGRAPHY• MARTINEZ SANCHEZ, Lina Maria; VARGAS GRISALES, Natalina; MEJIA

CARDONA, Laura; OSORIO OSPINA, Felipe; RAMIREZ PULGARIN, Sergio.

Biologia Molecular. 8 ed. Editorial Universidad Pontificia Bolivariana, 2015.

79-pg.

• Adapted by MNT from original release. (July 23rd of 2015). Modify DNA

building blocks are cancer’s Achilles heel. Retrieve from:

http://www.medicalnewstoday.com/releases/297189.php

• Adapted by MNT from original release. (July 27th of 2015). Mayor European

mouse study reveals the role of genes in disease. Retrieve from:

http://www.medicalnewstoday.com/releases/297341.php

• World cancer report 2014 (February 2015) Cancer. Retrieve

from: http://www.who.int/mediacentre/factsheets/fs297/en/