modified histone maprockland-inc.com/uploadedfiles/support/pathways/histone...histone h4 l p c e g...

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dified Histone Map Modified Histone Map Featured Modified Histone Antibodies www.rockland-inc.com [email protected] Histone H3 [Dimethyl Lys4] Epi-Plus TM is a jointly owned trademark of Novus Biologicals, LLC and Rockland Immunochemicals, Inc. Modified Histone Map © Novus Biologicals, LLC 2011. All Rights Reserved. H4 H4 H2B H2B H3 H3 H2A H2A H2A H2B H3 H2B H4 H4 H2B H2A R T K Q A G G A P Q A T A P T G G V H R R P G V A L R E I R R Y Q S T E L L I R L P F Q R L V R E I A Q D F D L R F Q S S/A A A L Q E A C/S E A Y L V G L F E D N L C A I H A V I M P D I Q L A R R I R G E R A A T S T K R K K A A R K S K K Y T K K K T T K R T K P Ac P P P Ac Me Me Ac Me Ac Me P Ac Me P P Ac Me Ac Me P P Ac P Ac Me 2 3 4 6 10 11 14 17 18 23 26 27 28 36 37 41 45 56 64 79 80 107 115 118 122 Histone H3 G G G G G L G G G A R H R V L R D D N I Q T P A I R R L A R R G G V R I G L I E E T R G V L V F L E N V I R D A V T Y T H E A R T V T A M D V V A L Q G R T L Y G F G S R K K K K K K S Y K K K Y K R P Ac Ac Me Ac Ac P P Me Ac Ac Me P Ac Me 1 3 5 8 12 16 20 31 47 51 59 77 79 88 91 92 Histone H4 L P Ac Me G Cit R 8 Me Cit K Ac 9 Cit Ac A/S 31 Ac Me 87 V/I 89 M/G 90 96 Cit I K 44 G Legend Me P Ac Acetylation Methylation Phosphorylation A - Alanine C - Cysteine D - Aspartic acid E - Glutamic acid F- Phenylalanine G - Glycine H - Histidine I - Isoleucine K - Lysine L - Leucine M - Methionine N - Asparagine P - Proline Q - Glutamine R - Arginine S - Serine T - Threonine V - Valine W - Tryptophan Y - Tyrosine Modifications: Residues: Cit Citrullination Me1 Me2 Me3 Monomethylation Dimethylation Trimethylation Me2 Me1 Me2 Me1 Me3 Me2 Me1 Me3 P Me2 Me1 Me3 Me2 Me1 Me2 Me1 Me2 Me1 Me2 Me1 Me3 Me2 Me1 Ac Me Isoform Residue Changes: Histone H3.2 C96 S96 Histone H3.3 A31 S31 S87 A87 V89 I89 M90 G90 C96 S96 Ac Histone H3 [Trimethyl Lys4] Histone H3 [Dimethyl Lys36] Histone H3 [Phospho Thr6] Histone H3 [Dimethyl Lys18] Histone H3 [Monomethyl Lys36] Histone H3 [Trimethyl Lys4] 600-401-I58 600-401-I59 600-401-I59 600-401-I63 600-401-I79 600-401-I87 600-401-I86

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Page 1: Modified Histone Maprockland-inc.com/uploadedFiles/Support/Pathways/histone...Histone H4 L P c e G it R 8 e it K c 9 it c A/S 31 c e 87 89 V/I 90 M/G 96 it I K 44 G Legend Me P c Acetylation

Modified Histone MapModified Histone Map

Featured Modified Histone Antibodies

www.rockland-inc.com [email protected]

Histone H3 [Dimethyl Lys4]

Epi-PlusTM is a jointly owned trademark of Novus Biologicals, LLC and Rockland Immunochemicals, Inc. Modified Histone Map © Novus Biologicals, LLC 2011. All Rights Reserved.

H4

H4

H2B

H2B

H3

H3

H2A

H2A

H2A

H2B

H3

H2B

H4

H4

H2B

H2A

RT K Q A

GG

AP

QA T

AP

TG

GV

H RR P G

VA

LR

EI

RR

YQ

ST

EL

L I R L P F QR

LV

RE

IAQ

DF

D L R FQ

SS/A

A

ALQ

EA

C/S

EA

YL V G L F E

D

NL

CA

IH

A

V

I MP

DIQLA

RR

IR G E

RA

A

T

ST

K

RK

K AA

RK

S

KK

YT

K

K

KT

T

KR

TK

P

AcP

P

P

Ac

Me

Me

Ac Me

Ac

MeP

Ac

Me

P

P

Ac

Me

Ac

Me

P

P

Ac

P

Ac

Me

2

34

6

10

11

14

17

18

23

26

27

28

36

37

4145

56

64

79

80

107

115

118122

Histone H3

GG

G GG L

G

GG

A

RH

R

VL R DD N I Q

T

PA

I

RR

LA

RR

GG V

R I G L I

EE

TR

GV

L

VF

L EN V I R D A V T Y T

HE

A

R

TV

TA M D V V

AL

QG

RT

L Y GF

G

SR

K K

K

K

K K

SY

KK

K

Y

KR

P

Ac

Ac

Me

Ac

Ac

P

P

Me

Ac

Ac

Me

P

Ac

Me1

35 8

12

16

20 31

47

51

5977

79

88

91

92

Histone H4

L

P

Ac

Me

G

CitR8

MeCit

KAc

9

Cit

Ac

A/S31

Ac

Me

87

V/I89M/G90

96

Cit

I

K44

G

Legend

Me

P

Ac Acetylation

Methylation

Phosphorylation

A - AlanineC - CysteineD - Aspartic acidE - Glutamic acidF- PhenylalanineG - GlycineH - Histidine

I - IsoleucineK - LysineL - LeucineM - MethionineN - AsparagineP - ProlineQ - Glutamine

R - ArginineS - SerineT - ThreonineV - ValineW - TryptophanY - Tyrosine

Modi�cations:

Residues:

Cit Citrullination

Me1

Me2

Me3

Monomethylation

Dimethylation

Trimethylation

Me2

Me1

Me2

Me1

Me3

Me2

Me1

Me3

P

Me2

Me1

Me3

Me2

Me1

Me2

Me1

Me2

Me1

Me2

Me1

Me3

Me2

Me1Ac

Me

Isoform Residue Changes:Histone H3.2 C96 S96Histone H3.3 A31 S31 S87 A87 V89 I89

M90 G90 C96 S96

Ac

Histone H3 [Trimethyl Lys4] Histone H3 [Dimethyl Lys36]Histone H3 [Phospho Thr6] Histone H3 [Dimethyl Lys18] Histone H3 [Monomethyl Lys36]Histone H3 [Trimethyl Lys4] 600-401-I58 600-401-I59 600-401-I59 600-401-I63 600-401-I79 600-401-I87 600-401-I86