MJPSManipal Journal of Pharmaceutical Sciences

Manipal University Press (MUP) is a unit of Manipal Academy of Higher Education (MAHE) Trust and is committed to the dissemination of knowledge generated within its vibrant academic environment and beyond.

Published by Manipal University Press (MUP), Manipal INDIAAdmin Off: Manipal Centre for European Studies (MCES), Behind Post Office, Manipal 576104 India

Published under the aegis of Directorate of Research, Manipal University, Manipal

Title: Manipal Journal of Pharmaceutical SciencesEditor: Dr Manthan D JanodiaISSN 2455-3735 (Online)

Volume: 2Issue: 1Month and Year: March-August, 2016Pages: 48

Cover page design: Arvind N, Manipal University Press, Manipal

No part of this publication may be reproduced in any form without prior permission of the publisher in writing.

Disclaimer: Opinions and views expressed in the articles are those of authors and do not reflect the idea or opinions of the publisher, Manipal University or Editorial Board. The publisher does not take legal responsibility for the accuracy of the content, or liability for any errors or omissions. The publisher does not endorse or refute opinions, views or suggestions regarding matter contained in the journal articles.

Printed at Manipal Technologies Ltd, Manipal

Manipal Journal of Pharmaceutical Sciences | March 2016 | Volume 2 | Issue 1 iii

Manipal Journal of Pharmaceutical Sciences

Editorial Board 2016

EDITORManthan D Janodia, PhDAssociate Professor, Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

MANAGING EDITORM Surlivel Rajan, PhDAssociate Professor, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

ASSOCIATE EDITORSAlex Joseph, PhDAssociate Professor, Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Srinivas Mutalik, PhDProfessor, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Saleemulla Khan, PhDAssociate Professor – Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Rekha Shenoy, PhDAssociate Professor, Department of PharmacologyManipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Sudheer Moorkoth, PhDAssociate Professor, Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

D Sreedhar, PhDAssociate Professor, Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Angel Alex, PhDAssistant Professor (Senior Scale) – Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Sreedharan Nair, PhDAssociate Professor, Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

EDITORIAL ADVISORY BOARDNayanabhirama Udupa, PhDDirector Research (Health Sciences) – Manipal University, Manipal University, Manipal 576104, Karnataka, India

Padma V Devarajan, PhDProfessor and Head, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400019, India

Vandana B. Patravale, PhDProfessor of Pharmaceutics, Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai-400019, Maharashtra, India

S Narasimha Murthy, PhDAssociate Professor-Pharmaceutics, 113 Faser Hall, The University of Mississippi, MS 38677, USA

Sanyog Jain, PhDAssociate Professor, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Chandigarh, Punjab, India

M Sreenivasa Reddy, PhDVice Principal and Professor, Department of Pharmaceutics – Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, Karnataka, India

iv Manipal Journal of Pharmaceutical Sciences | March 2016 | Volume 2 | Issue 1

Ananth Pannala, PhDPrincipal Lecturer of Pharmaceutics, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton - BN2 4GJ, UK

M Srinath Baliga, PhDScientist: Research and Development, Father Muller Medical College, Mangalore 575002, Karnataka, India

Santosh L Vishwakarma, PhDAssistant Director- Discovery Biology, Jubilant Biosys, Bangalore, India

K N Chidambara Murthy, PhDPrincipal Scientist (Scientist-E), Central Research Laboratory, MS Ramaiah Medical College and Teaching Hospital, MSR Hospital Building (1st Floor), MSRIT Post, Bangalore-560 054, India

Tuhinadri Sen, PhDAssociate Professor, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India

C Mallikarjuna Rao, PhDPrincipal, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India

Deepak Mundkinajeddu, PhDSenior Manager- Phytochemistry, Research and Development Centre, Natural Remedies Private LimitedBangalore- 560100

S P Dhanbal, PhDProfessor and Principal, JSS College of Pharmacy, Ooty,Rocklands, Ooty – 643001, Tamilnadu, India

Raman Dang, PhDProfessor and Principal, Krupanidhi College of Pharmacy,#12/1, Chikka Bellandur, Carmelaram Post, Varthur Hobli, Bangalore – 560035, INDIA

M N A Rao, PhDGeneral Manager, R&D, Divi’s Laboratories Limited, Hyderabad-500 018, Telangana

S B Katti, PhDChief Scientist, Medicinal Chemistry Division, Central Drug Research Institute, Lucknow- 226 001

S Krishnan, PhDProfessor and Head, Department of Pharmaceutical Biotechnology, College of Pharmacy, SRIPMS, Coimbatore-641044, Tamilnadu, India

Veerbrahma Kishan, PhDProfessor and Head, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana – 506 009, India

Sohil AK, PhDPharmacotherapeutics and Quality Use of Medicines, School of Pharmacy, Griffith University, Gold Coast, QLD 4222, Australia

Andrew Davey, PhDHead, School of Pharmacy, Griffith Health, Griffith University, Gold Coast, QLD 4222

M D Burande, PhDHonorary Director, Institute of Pharmaceutical Education and Research, Pune, India

S N Meyyanathan, PhDProfessor and Head, Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ooty, Tamil Nadu, India.

Ruth Godfrey, PhDScientist and Lecturer in Institute of Mass Spectrometry, Room 359, Grove Building, College of Medicine, Swansea University, Swansea SA2 8PP, U.K.

Sanjay Pai P N. PhDProfessor and HOD in Pharmaceutical Chemistry, (i/c) Pharmaceutical Analysis, Goa College of Pharmacy, Panaji-Goa, 403 001

Sureshwar Pandey, PhDDirector, School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St Augustine Campus, Trinidad and Tobago

Manipal Journal of Pharmaceutical Sciences | March 2016 | Volume 2 | Issue 1 v

Invited Editorial

From ‘Made in India’ to ‘Make in India’ in Pharmaceuticals

S K Kulkarni ................................................................................................................................................................................................. 1

Review article

Usage of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in diabetic hypertensive patients

Anil Tumkur, Christie Tang Wen Yee, Edrea Lim Ciin Yee, Foo Siang Sheng, Tay Shun Ern ..................................................................... 3

Original articles

Development and Evaluation of Ethosomal Gel of Lornoxicam for Transdermal Delivery: In-Vitro and In-Vivo Evaluation

Ankit Acharya, Mohammed Gulzar Ahmed, Baba Datteshwara Rao, Vinay C H ...................................................................................... 13

Cytotoxic potential of medicinal plants – A comparative evaluation

Litty Joseph, K K Srinivasan, Sudheer Moorkoth, Jyoti Harindran ................................................................................................................. 21

Efficacy of methanolic extract of Piper longum on endothelial function in vitro and ex vivo

Vinay Kumar Kanakpura, Sumanta Kumar Goswami, Shekhar Dethe, Mohammed Naserrudin Inamadar .................................................. 26

Perspective

Mesenchymal Stem cells derived from human perinatal tissues as a model for drug screening and toxicity testing

Nitya Shree and Ramesh R Bhonde ................................................................................................................................................................ 33

CONTENT

Message from Director Research (Health Sciences), Manipal University

Manipal University is one of the leading Universities in India, imparting quality education and is actively involved in research activities. Manipal University has always given equal importance to both education and research.

Directorate of Research, Manipal University has taken the responsibility to enhance research performance of the University through various measures and one of the measures is publication of quality journals in the fields of Medicine, Dentistry, Pharmacy, Nursing, Engineering and Technology, Management and Humanities. Manipal Journal of Pharmaceutical Sciences (MJPS), biannual publication is one of the six such journals with first issue released in September 2015. The first issue featured two Invited Editorials from eminent scholars from India and abroad, and six original research articles.

The second issue has one Invited Editorial, one Review article, three original research articles and one perspective article. The second issue of the journal offers the readers a wide array of concepts in the field of pharmaceutical sciences. The young and energetic Editorial Board has ensured that the journal meets the required criteria to ensure high quality while accepting the manuscripts for publication. The journal also ensures that the manuscripts submitted for the publication undergo through plagiarism check.

The journal has also received ISSN for online presence. At present the abstracts of the articles from the first issue are available on our online platform https://ejournal.manipal.edu/mjps. We have developed an online platform for manuscript submission which would facilitate authors to submit their manuscripts online and track the progress of their manuscript. The online platform can be accessed at https://ejournal.manipal.edu/jcms.

We look forward to authors and encourage them to contribute good quality research work for publishing in MJPS.

We thank management of Manipal University for their support and encouragement. We hope to see good number of researchers and scientists contributing as subscribers and contributors to MJPS.

Dr N UdupaDirector Research (Health Sciences)Manipal UniversityManipal