mips molecular imaging program at stanford school of medicine department of radiology stem cell...
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MIPSMolecular ImagingProgram at Stanford
School of MedicineDepartment of Radiology
Stem Cell Therapy & Cardiovascular Molecular Imaging
Joseph Wu, MD, PhDDepartment of Medicine/Cardiology
Department of Radiology/Nuclear MedicineEmail: [email protected]
Stanford
• Coronary heart disease is the #1 cause of morbidity and mortality in the US.
• CHF is the #1 cause of hospitalization for those age >65 yo.
• Annual health care costs related to cardiovascular diseases was ~ $220 billion last year.
• Stem cell transplant is a promising and exciting therapy.
Background
2004 American Heart Association UpdateOrlic D, et al. Nature 2001
• Bone marrow stem cells (BMSC)• Endothelial progenitor cells (EPC)• Mesenchymal stem cells (MSC)• Skeletal myoblasts (SKM)• Embryonic stem cells (ESC)• Cardiac stem cells (CSC)• Cardiac progenitor cells (isl1+)
Available Stem Cells
**Stem cells are capable of self-renewal, transformation into dedicated progenitor cells, and differentiation into specialized progeny
Wu JC et al, Circulation 2003
Imaging Embryonic Cardiomyoblasts Survival
Optical Imaging MicroPET Imaging
horizontal coronal sagittal
[18F]-FHBG
[18F]-FDG
Fusion
0%ID/g
1%ID/g
0%ID/g
3%ID/g
PET Imaging of ESC Transplant
Imaging ES Cell Differentiation into Cardiomyocytes
Nkx 2.5-eGFP 12 days after embryoid body differentiation