mid-ir laser imaging for molecular recognition in security and medical applications
DESCRIPTION
Mid-IR laser imaging for molecular recognition in security and medical applications. Anadi Mukherjee. I nfra S ign Fremont, CA. I nfra S ign. Lasers, Optics & Photonics, Oct 7-9, 2013. I nfra S ign. Revealing the Invisible for a Safer World. Mid-IR laser imaging for - PowerPoint PPT PresentationTRANSCRIPT
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Mid-IR laser imaging for molecular recognition in
security and medical applications
Lasers, Optics & Photonics, Oct 7-9, 2013 InfraSign
Anadi Mukherjee
InfraSignFremont, CA
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Mid-IR laser imaging for
Molecular Recognition
www.infrasign.com
Security HAZMATs Food Safety
Medical Tagless Pathology Pharma QC/QA
Hand-held, battery operated system
2 InfraSignLasers, Optics & Photonics, Oct 7-9, 2013
Revealing the Invisible for a Safer World
InfraSign
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LaserCamera
Trace MoleculesOr
Molecular Modifications
Strong fundamental Vibrations (MIR) vs. Weak Overtone (NIR) or Raman
Lasers, Optics & Photonics, Oct 7-9, 20133
Hyperspectral Imaging
l3
l2 l1
l4
MIRIS – Mid-IR Imaging Spectroscopy Diffuse Reflection
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4 InfraSignLasers, Optics & Photonics, Oct 7-9, 2013
SecurityTrace HAZMATS & Narcotics
MedicalFood Safety - Biocontamination Sensor
Pharma - Real-time in-line Quantitative QC/QA
Laser Pathology - Antibody-free Diagnosis Body FluidsTissues – Cancer Biomarkers
In-vivo diagnosis/surgery, New Microarrays
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Security
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Hand-held, battery operated, 9”x7”x4”, < 4 lbs
12”
SPoT - Sensitive Picture of Traces
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Explosive/Binder
AN
HMTD
TNT
Urea Nitrate
Sugar Urea NitrateTNT
AN
Sugar
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9.5um7.38um
R
9.25um
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7.38 mm 9.5 mm
9.25 mm
3 QCLs
7
FP
DFB
DFB
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SPoT raw image results of AN trace on polyethylene
9.25um7.38um 9.5um
Abso
rptio
nIn
cide
nt b
eam
s
Very thin (cloudy) film of AN on polyethylene film
9.5um
9.25um
7.38um
R
6”
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Validation
• First explosive trace imaging system sold for use by US Navy
• Customer quote: “(SPoT) continues to function well despite the traveling it has done. The hardware has proven to be remarkably robust.”
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Safety & Medical
Industrial Plant Safety/TICs Food Safety
Medical Imaging
Pharmaceutical QC/QA
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Fundamental Biomolecular Vibrations
Fatty Acids
Proteins
Sugars
Overlap
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SensitivitySpecificity
PFA of 10-2 (PD of 99%)
77ug/cm2
Hyperspectral Imagingof Serum Protein
ROC Curve
PD of 99%
Anadi Mukherjee et al “Spectroscopic imaging of serum proteins using quantum cascade lasers”, Journal of Biomedical Optics 18(3), 036011 (March 2013).
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Acknowledgements
Pathology Department UCSF
Professor Tarik Tihan, UCSF
Manu Prasanna
Steve Barnett
Quentin Bylund
Biswaroop Mukherjee
Block Engineering – Petros Kotidis
Adtech Optics – Mariano Troccoli
ThorLabs – John Bruno
ThanksLasers, Optics & Photonics, Oct 7-9, 201314