memorandum chloropicrin. chemistry chapter for the

10-29-04

MEMORANDUM

SUBJECT: Chloropicrin. List A Reregistration Case 0040. PC Code 081501. Product Chemistry Chapter for the Reregistration Eligibility Decision [RED] Document. DP Barcode D268927.

FROM: K. Dockter, ChemistReregistration Branch 2Health Effects Division [7509C]

THRU: Alan Nielsen, Branch Senior ScientistReregistration Branch 2Health Effects Division [7509C]

TO: Elissa Reaves, PhD and Bill Smith, Risk AssessorsReregistration Branch 2Health Effects Division [7509C]

Attached is the RED product chemistry chapter for the insecticide chloropicrin[trichloronitromethane]; which is a non-selective fumigant registered for post harvest use onmany grains. This chapter was assembled by Dynamac Corporation under supervision of RRB2. The data assessment has undergone secondary and tertiary review in the Branch and has beenrevised to reflect Agency policies. Most product chemistry data requirements remain outstandingfor the six MPs eligible for reregistration.

Attachment: Reregistration Eligibility Decision: Product Chemistry Considerations

cc: List B file, SF, RF, Dockter, E. Reaves, B. Smith, S. Ary. .RD\I RRB2 Chloropicrin RED Team.7509C:RRB2:Rm712P:57886:KD/kdChloropicrin.RED [55] = D268927.mem.

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDESAND TOXIC SUBSTANCES

2

MEMORANDUM

Date: Dynamac DRAFT Submitted 09/21/04

Subject: Chloropicrin RED - Reregistration Eligibility Decision. Product ChemistryConsiderations. Case No. 0040

DP Barcode: DtbdPC Code: 081501

From: K. Dockter, ChemistRRB3Health Effects Division (7509C)

Through: 2/Reviewer, ChemistBranchHealth Effects Division (7509C)

3/Reviewer, Branch Senior ScientistBranchHealth Effects Division (7509C)

Chemistry Science Advisory CouncilHealth Effects Division (7509C)

To:

This document was originally prepared under contract by Dynamac Corporation (20440 CenturyBoulevard, Suite 100; Germantown, MD 20874; submitted 09/21/2004). The document has beenreviewed by the HED and revised to reflect current OPP policies.

3

Executive Summary

Chloropicrin [trichloronitromethane] is a non-selective soil and space commodity fumigant usedfor the control of weeds, nematodes, insects, rodents, and certain fungi. It is also a warning agentfor use with odorless fumigants, such as methyl bromide.

Chloropicrin is a FIFRA List A reregistration chemical. The Chloropicrin ReregistrationStandard dated 12/7/81 and Guidance Document dated 9/82 required additional generic andproduct-specific product chemistry data concerning chloropicrin. A generic Data Call-In Notice(DCI) was issued 9/28/90 to the manufacturers of chloropicrin. Only the Great Lakes and Niklortechnical products were registered at the time of the Reregistration Standard. The reregistrationof chloropicrin is being supported by the Chloropicrin Manufacturers’ Task Force (CMTF)including members Niklor Chemical Company; Ashta Chemicals; Trinity Manufacturing, AngusChemical Co.; Great Lakes Chemical Corporation; Soil Chemical Corporation Products;TRICAL; and Dow Agrosciences LLC.

We note that this RED chapter only addresses product chemistry data requirements for theregistered manufacturing-use products of chloropicrin. If any of the registered end-use productsare manufactured by an integrated system from unregistered TGAIs, product chemistry data mustbe submitted for the TGAIs for these products as well.

The outstanding product chemistry data requirements for the chloropicrin MPs are summarizedin Table 1 and are detailed in the attached data summary tables. Provided that the registrantssubmit the data required in the attached data summary tables for the chloropicrin MPs, and eithercertify that the suppliers of beginning materials and the manufacturing processes for thechloropicrin T/TGAIs and FIs have not changed since the last comprehensive product chemistryreview or submit complete updated product chemistry data packages, the Agency has noobjections to the reregistration of chloropicrin with respect to product chemistry datarequirements.

Product Chemistry Deficiencies

Product chemistry deficiencies pertaining to individual products are summarized in Table 1.

TABLE 1. Product Chemistry Data Requirements for Chloropicrin Manufacturing-Use Products.

Product EPA Reg. No. Registrant OPPTS Guideline Requirements 1

99% T 5785-58 Great Lakes ChemicalCorporation

Repackaged product; data requirements willbe satisfied by data for the technical sourceproducts.

33% FI 5785-52 830.1670, 1800, 6302, 6303, 6304, 6314,6315, 6317, 6320, 7100, and 7300

99% T 7747-1 Niklor Chemical Company,Inc.

830.1550, 1600, 1700, 1800, and 7050

99.4% T 62341-15 Trinity Manufacturing, Inc. 830.1600, 6314, 6315, 6317, 6320, 7050,and 7100

TABLE 1. Product Chemistry Data Requirements for Chloropicrin Manufacturing-Use Products.

Product EPA Reg. No. Registrant OPPTS Guideline Requirements 1

4

Cl

Cl

ClO2N

99.3% T 62531-1 Ashta Chemicals, Inc. 830.1550, 1700, 1750, 1800, 6314, 6315,6317, 6320, 7050, and 7100

99.5% T 66330-37 Arvesta Corporation 830.1550, 1700, 1750, 1800, 6313, 6314,6315, 6317, 7050, and 7100; pendingconfirmation that the manufacturing site andprocess has not changed since the producttransfer

1 Minor administrative revisions required for CSFs (e.g, changes to update registrant or Reg. No. or corrections tonominal concentrations or certified limits) were not identified as data gaps and are detailed in the individual datasummary tables.

Background

Identification of Active Ingredient

The PC code and nomenclature of chloropicrin are presented in Table 2. The physicochemicalproperties of chloropicrin are listed in Table 3.

TABLE 2. Chloropicrin Nomenclature

Chemical structure

Common name chloropicrin

Molecular Formula CCl3NO2

Molecular Weight 164.38

IUPAC name trichloronitromethane

CAS name trichloronitromethane

CAS # 76-06-2

TABLE 3. Physicochemical Properties of Chloropicrin

Parameter Value Reference

Boiling point Slowly decomposes to COCl2 and NOCl at112 °C; emits highly toxic fumes withheating.

Product Chemistry Chapter, ChloropicrinReregistration Standard, 12/7/81

pH Not applicable because of the limitedsolubility of chloropicrin in water

Density, bulk density,or specific gravity

1.7 g/mL at 25 °CProduct Chemistry Chapter, ChloropicrinReregistration Standard, 12/7/81

Water solubility 0.2 g/100 g; decomposes in water solutionsto form corrosive substances

TABLE 3. Physicochemical Properties of Chloropicrin

Parameter Value Reference

5

Solvent solubility Highly soluble (>0.5 g/mL) in acetone,ethanol, hexane, and xylene.

D199961, 5/26/94, F. Toghrol

Vapor pressure 18.3 mm Hg at 21 °C Product Chemistry Chapter, ChloropicrinReregistration Standard, 12/7/81

Dissociation constant,pKa

Not applicable because chloropicrin isnonpolar and does not dissociate

Octanol/waterpartition coefficient

log KOW = 2.58 D197238, 3/29/94, F. Toghrol

UV/visible absorptionspectrum

not given

Manufacturing-use Products

A search of the OPPIN product listing conducted 7/04 identified six registered manufacturing-use products (MPs) under PC Code 081501. We note that OPPIN also identified the ShadowMountain Products Corp. 94% product (EPA Reg. No. 58266-5); Ashta Chemicals, Inc. 99.3%product (EPA Reg. Nos. 62531-2); Arvesta Corp. 99% product (EPA Reg. No. 66330-47); andApplied Agrosciences, Inc. 99% product (EPA Reg. No. 73686-1) as technical products;however, based on examination of the product labels, these products are correctly identified asend-use products. The registered chloropicrin MPs subject to a reregistration eligibility decisionare presented in Table 4.

TABLE 4. Registered chloropicrin manufacturing-use products.

Formulation EPA Reg. No. Registrant Comments/Transfers

99% T 5785-58 Great Lakes ChemicalCorporation

Repackaged from EPA-registered products.

33% FI 5785-52 Formulated from EPA-registered products.

99% T 7747-1 Niklor ChemicalCompany, Inc.

none

99.4% T 62341-15 TrinityManufacturing, Inc.

Transferred 11/26/93 from Shadow MountainProducts Corporation (EPA Reg. No. 58266-4), whichhad been transferred 9/1/87 from Trical (EPA Reg.No. 11220-14).

99.3% T 62531-1 Ashta Chemicals, Inc. Transferred 1/28/91 from Wright Corporation (EPAReg. No. 58493-1).

99.5% T 66330-37 Arvesta Corporation(formerly Tomen

Agro, Inc.)

Transferred 4/30/01 from Holtrachem ManufacturingCompany, LLC (EPA Reg. No. 61219-1), which hadbeen transferred 8/12/94 from LCP Chemicals (EPAReg. No. 21139-2; Holtrachem was formerly LCPChemicals).

6

830.1550-7950 Product Chemistry Data Requirements

The current status of the product chemistry data requirements for the chloropicrin MPs ispresented in the attached data summary tables. Refer to these tables for a listing of theoutstanding product chemistry data requirements.

7

Case No. 0040PC Code 081501

Case Name: ChloropicrinRegistrant: Great Lakes Chemical CorporationProduct(s): 99% T (EPA Reg. No. 5785-58)

PRODUCT CHEMISTRY DATA SUMMARY

GuidelineNumber Requirement

Are DataRequirements

Fulfilled? 1 MRID Number 2

830.1550 Product identity and composition Y 3 CSF 5/15/98830.1600 Description of materials used to produce the product N/A830.1620 Description of production process N/A830.1670 Discussion of formation of impurities N/A830.1700 Preliminary analysis N/A830.1750 Certified limits Y CSF 5/15/98830.1800 Enforcement analytical method N/A830.6302 Color N/A830.6303 Physical state N/A830.6304 Odor N/A830.6313 Stability to normal and elevated temperatures, metals,

and metal ionsN/A

830.6314 Oxidation/reduction: chemical incompatibility N/A830.6315 Flammability N/A830.6316 Explodability N/A830.6317 Storage stability N/A830.6319 Miscibility N/A830.6320 Corrosion characteristics N/A830.7000 pH N/A830.7050 UV/visible absorption N/A830.7100 Viscosity N/A830.7200 Melting point/melting range N/A830.7220 Boiling point/boiling range N/A830.7300 Density/relative density/bulk density N/A830.7370 Dissociation constants in water N/A830.7550 Partition coefficient (n-octanol/water), shake flask

methodN/A

830.7840 Water solubility: column elution method; shake flaskmethod

N/A

830.xxxx Solvent solubility N/A830.7950 Vapor pressure N/A

1 Y = Yes; N = No; N/A = Not Applicable. This product is repackaged from EPA-registered products; all productchemistry data requirements will be satisfied by data for the technical source products.

2 The CSF dated 5/15/98 was reviewed by the Registration Division (Letter dated 7/8/98, from M. Waller, RD, to P.Bricker, Great Lakes Chemical Corp.).

3 The CSF should be revised to reflect the current company name and EPA Reg. No. for one of its sources which hasbeen transferred.

8


Case Name: ChloropicrinRegistrant: Great Lakes Chemical CorporationProduct(s): 33% FI (EPA Reg. No. 5785-52)





830.1550 Product identity and composition Y 3 CSF 4/19/97830.1600 Description of materials used to produce the product Y 44230001830.1650 Description of formulation process Y 44230001830.1670 Discussion of formation of impurities N 830.1700 Preliminary analysis N/A 4 830.1750 Certified limits Y CSF 4/19/97830.1800 Enforcement analytical method N 830.6302 Color N 830.6303 Physical state N 830.6304 Odor N 830.6313 Stability to normal and elevated temperatures, metals,

and metal ionsN/A 4

830.6314 Oxidation/reduction: chemical incompatibility N 830.6315 Flammability N 830.6316 Explodability N/A 5

830.6317 Storage stability N 830.6319 Miscibility N/A 5

830.6320 Corrosion characteristics N830.7000 pH N/A 6

830.7050 UV/visible absorption N/A 4

830.7100 Viscosity N 830.7200 Melting point/melting range N/A 4

830.7220 Boiling point/boiling range N/A 4

830.7300 Density/relative density/bulk density N 830.7370 Dissociation constants in water N/A 4

830.7550 Partition coefficient (n-octanol/water), shake flaskmethod

N/A 4


N/A 4

830.xxxx Solvent solubility N/A 4

830.7950 Vapor pressure N/A 4

1 Y = Yes; N = No; N/A = Not Applicable. This product is formulated from EPA-registered products.

2 MRID 44230001 was reviewed by the Registration Division (RD) under D234151, 7/1/97, A. Smith; the CSF dated4/19/97 was accepted by the Registration Division (Letter dated 10/10/97, from M. Waller, RD, to P. Bricker, GreatLakes Chemical Corp.).

3 The CSF should be revised to reflect the current company name and EPA Reg. No. for one of the source productswhich has been transferred, and to remove a source which is no longer registered.

4 TGAI/PAI data requirements will be fulfilled by data for the technical source product(s).

9

5 Data waiver granted by Greybeard Committee (10/19/94) based on the properties of chloropicrin.

6 Data are not required because of the limited solubility of chloropicrin in water.

10


Case Name: ChloropicrinRegistrant: Niklor Chemical Company, Inc.Product(s): 99% T (EPA Reg. No. 7747-1)





830.1550 Product identity and composition N 3 43090201, CSF 1/12/94830.1600 Description of materials used to produce the product N 4 43090201, Letter 10/14/94 5

830.1620 Description of production process Y 43090201, Letter 10/14/94 5

830.1670 Discussion of formation of impurities Y 43090201830.1700 Preliminary analysis N 6 43097901, Letter 10/14/94 5

830.1750 Certified limits Y 7 43090202830.1800 Enforcement analytical method N 8 43090202, Letter 10/14/94 5

830.6302 Color Y 43097902830.6303 Physical state Y 43097902830.6304 Odor N/A 9

830.6313 Stability to normal and elevated temperatures, metals,and metal ions

Y 43097902

830.6314 Oxidation/reduction: chemical incompatibility Y 43434601 5

830.6315 Flammability Y 00013198830.6316 Explodability N/A 10 830.6317 Storage stability Y 00013198830.6319 Miscibility N/A 10

830.6320 Corrosion characteristics Y 00013198830.7000 pH N/A 11

830.7050 UV/visible absorption N 830.7100 Viscosity Y 43434601 5

830.7200 Melting point/melting range N/A 12

830.7220 Boiling point/boiling range Y 43097902830.7300 Density/relative density/bulk density Y 43097902830.7370 Dissociation constants in water N/A 13


Y 43022402 14


Y 43097902

830.xxxx Solvent solubility Y 43097902830.7950 Vapor pressure Y 43097902

1 Y = Yes; N = No; N/A = Not Applicable.

2 Bolded references were evaluated under the Guidance Document dated 9/82; underlined references were reviewedunder D199152 and D198927, 7/12/94, S. Knizner; and remaining references were reviewed as noted.

3 The accuracy of the method used to generate data for the CSF cannot be determined because a reference standardwas not used; therefore, a new CSF is required based on data obtained using a certified chloropicrin referencestandard.

4 A discrepancy concerning the starting materials used in the first step of the manufacturing process must beresolved.

11

5 D211265, 5/8/95, S. Knizner.

6 Additional data must be obtained using a certified chloropicrin reference standard.

7 The Branch notes that, based on the results of the preliminary analysis, upper certified limits are not required forthe impurities (<0.1%) listed on the CSF.

8 Additional validation data are required for the method used to quantitate chloropicrin.

9 Data addressed and accepted in the Chloropicrin Guidance Document indicated that the odor of chloropicrin isstrongly lachrymatory. Due to the inhalation hazard associated with the test substance, no additional data arerequired.



12 Data are required because the TGAI is a liquid at room temperature.

13 Data are not required because the TGAI is nonpolar and does not dissociate.

14 Task Force data: D197238, 3/29/94, F. Toghrol.

12


Case Name: ChloropicrinRegistrant: Trinity Manufacturing, Inc.Product(s): 99.4% T (EPA Reg. No. 62341-15)





830.1550 Product identity and composition Y 43091301, CSF 1/14/94830.1600 Description of materials used to produce the product N 3 43091301830.1620 Description of production process Y 43091301830.1670 Discussion of formation of impurities Y 43091301830.1700 Preliminary analysis Y 43137001830.1750 Certified limits Y CSF 1/14/94830.1800 Enforcement analytical method Y 43137001830.6302 Color Y 43137002830.6303 Physical state Y 43137002830.6304 Odor N/A 4


Y 43137002

830.6314 Oxidation/reduction: chemical incompatibility N 830.6315 Flammability N 830.6316 Explodability N/A 5 830.6317 Storage stability N 830.6319 Miscibility N/A 5

830.6320 Corrosion characteristics N 830.7000 pH N/A 6

830.7050 UV/visible absorption N 830.7100 Viscosity N 830.7200 Melting point/melting range N/A 7 830.7220 Boiling point/boiling range Y 43137002830.7300 Density/relative density/bulk density Y 43137002830.7370 Dissociation constants in water N/A 8 830.7550 Partition coefficient (n-octanol/water), shake flask

methodY 43022402 9


Y 43137002



2 Bolded references were reviewed under D198925, 7/12/94, S. Knizner; underlined references were reviewed underD199961, 5/26/94, F. Toghrol; and remaining references were reviewed as noted.

3 The sources and specifications must be submitted for two starting materials.


13



7 Data are not required because the TGAI is a liquid at room temperature.



14


Case Name: ChloropicrinRegistrant: Ashta Chemicals, Inc.Product(s): 99.3% T (EPA Reg. No. 62531-1)





830.1550 Product identity and composition N 3 43091401, CSF 1/15/94,Letter 1/24/95 4

830.1600 Description of materials used to produce the product Y 43091401, Letter 1/24/95 4

830.1620 Description of production process Y 43091401, Letter 1/24/95 4

830.1670 Discussion of formation of impurities Y 43091401, Letter 1/24/95 4

830.1700 Preliminary analysis N 5 43091402, Letter 1/24/95 4

830.1750 Certified limits N 3, 6 CSF 1/15/94, Letter 1/24/95 4

830.1800 Enforcement analytical method N 7 43091402, Letter 1/24/95 4

830.6302 Color Y 43133101830.6303 Physical state Y 43133101830.6304 Odor N/A 8


Y 43133101

830.6314 Oxidation/reduction: chemical incompatibility N 830.6315 Flammability N 830.6316 Explodability N/A 9 830.6317 Storage stability N 830.6319 Miscibility N/A 9

830.6320 Corrosion characteristics N 830.7000 pH N/A 10

830.7050 UV/visible absorption N 830.7100 Viscosity N 830.7200 Melting point/melting range N/A 11 830.7220 Boiling point/boiling range Y 43133101830.7300 Density/relative density/bulk density Y 43133101830.7370 Dissociation constants in water N/A 12 830.7550 Partition coefficient (n-octanol/water), shake flask

methodY 43022402 13


Y 43133101



2 Bolded references were reviewed under D198923, 7/12/94, S. Knizner; underlined references were reviewed underD199962, 5/26/94, F. Toghrol; and remaining references were reviewed as noted.

3 The accuracy of the method used to generate data for the CSF cannot be determined because a reference standardwas not used; therefore, a new CSF is required based on data obtained using a certified chloropicrin referencestandard.

4 D213751, 5/8/95, S. Knizner.

15


6 We note that upper certified limits are not required for impurities determined at <0.1%.

7 Additional validation data are required for the method used to quantitate chloropicrin.







16


Case Name: ChloropicrinRegistrant: Arvesta CorporationProduct(s): 99.5% T (EPA Reg. No. 66330-37)





830.1550 Product identity and composition N 3

830.1600 Description of materials used to produce the product Y 42400001, 42400002830.1620 Description of production process Y 42400001, 42400002830.1670 Discussion of formation of impurities Y 4240000830.1700 Preliminary analysis N 4 42400002830.1750 Certified limits N 3

830.1800 Enforcement analytical method N830.6302 Color Y 4242700830.6303 Physical state Y 42427001830.6304 Odor N/A5 42427001830.6313 Stability to normal and elevated temperatures, metals,

and metal ionsN 6 42427001

830.6314 Oxidation/reduction: chemical incompatibility N 830.6315 Flammability N 830.6316 Explodability N/A7

830.6317 Storage stability N 830.6319 Miscibility N/A 7

830.6320 Corrosion characteristics N830.7000 pH N/A 8

830.7050 UV/visible absorption N 830.7100 Viscosity N 830.7200 Melting point/melting range N/A 9 830.7220 Boiling point/boiling range Y 42427001830.7300 Density/relative density/bulk density Y 42427001830.7370 Dissociation constants in water N/A 10


Y 43022402 11


Y 4242700


1 Y = Yes; N = No; N/A = Not Applicable. The Arvesta technical was transferred from Holtrachem ManufacturingCompany (EPA Reg. No. 61219-1). The database presented represents product chemistry data submitted byHoltrachem; Arvesta the current registrant must confirm that the manufacturing site and process has not changedsince the product transfer; otherwise, additional data may be required.

2 All references were reviewed under D182763, 12/29/92, A. Aikens, unless otherwise noted.

3 When adequate preliminary analysis data are available, an updated CSF must be submitted including the productcomposition, nominal concentrations, and certified limits for the active ingredient and all components present at$0.1% in the product, and the current registrant and registry number.

17



6 Stability of the TGAI upon exposure to metals and metal ions is required.






18

BIBLIOGRAPHY

Study Citations

00013198 Niklor Chemical Company, Incorporated (1966?) Chloropicrin. (Unpublished studyreceived Dec 13, 1976 under 7747-1; CDL: 227686-C)

42400001 Tonini, D. (1991) Chloropicrin: Beginning Materials and Manufacturing Process -Discussion of Formation of Impurities. Unpublished study prepared by LCP Chemicals - Maine. 35 p.

42400002 Tonini, D. (1991) Chloropicrin: Preliminary Analysis. Unpublished study prepared byLCP Chemicals - Maine. 14 p.

42427001 Tonini, D. (1992) Chloropicrin - Physical and Chemical Characterization. Unpublished compilation. 21 p.

43022402 Secara, S. (1990) Chloropicrin - Octanol/Water Partition Coefficient: Lab ProjectNumber: BR 173:90. Unpublished study prepared by Bolsa Research Associates, Inc. 11 p.

43090201 Wilhelm, S. (1994) Product Identity, Beginning Materials, Manufacturing Process, andFormation of Impurities for Chloropicrin Production at Niklor Chemical Company, Inc.: LabProject Number: N101941. Unpublished study prepared by Niklor Chemical Co., Inc. 55 p.

43090202 Wilhelm, S. (1994) Administrative Materials: Confidential Statement of Formula:Certification Statement: Chloropicrin: Lab Project Number: N101942. Unpublished studyprepared by Niklor Chemical Co., Inc. 6 p.

43091301 Perreault, V. (1994) Technical Chloropicrin: Product Chemistry: Guideline Series 61:Supplemental Information: Lab Project Number: TMI 94-I. Unpublished study prepared by Trinity Manufacturing, Inc. 35 p.

43091401 Carr, G.; Werman, R. (1994) Chloropicrin Product Chemistry. Unpublished study. 35 p.

43091402 Sparacino, C. (1994) Preliminary Analysis for Chloropicrin: Final Report: Lab ProjectNumber: 70C-5630-001: CMTF-001: RTI/5630-ASH1/F. Unpublished study prepared byResearch Triangle Institute. 60 p.

43097901 Sparacino, C. (1994) Preliminary Analysis for Chloropicrin: Final Report: Lab ProjectNumber: 70C/5630/001: 70C/5630: RT1/5630/NIK1/F. Unpublished study prepared byResearch Triangle Institute. 60 p.

43097902 Sparacino, C. (1994) Product Chemistry for Chloropicrin: Final Report: Lab ProjectNumber: 70C/5630/001: 70C/5630: RTI/5630/NIK2/F. Unpublished study prepared by ResearchTriangle Institute. 86 p.

19

43133101 Sparacino, C. (1994) Product Chemistry for Chloropicrin: Final Report: Lab ProjectNumber: 70C-5630-001. Unpublished study prepared by Research Triangle Institute. 86 p.

43137001 Sparacino, C. (1994) Preliminary Analysis for Chloropicrin: Final Report: Lab ProjectNumber: 70C-5630-001. Unpublished study prepared by Research Triangle Institute. 58 p.


43206001 Sparacino, C. (1994) Preliminary Analysis for Chloropicrin Composite: Final Report:Lab Project Number: 70C-5630-001. Unpublished study prepared by Research Triangle Institute.55 p.

43373501 Gauvin, D. (1994) Chloropicrin: Product Identity and Composition. Unpublishedstudy prepared by HoltraChem Manufacturing Co. 19 p.

43373502 Sparacino, C. (1994) Preliminary Analysis for Chloropicrin: Final Report: Lab ProjectNumber: 70C/5630/001. Unpublished study prepared by Research Triangle Institute. 38 p.

43434601 Siemann, L. (1994) Product Chemistry for Chloropicrin: Oxidizing/Reducing Action:Viscosity: Lab Project Number: 3807/F. Unpublished study prepared by Midwest Research Institute. 15 p.


44230001 Howland, M. (1997) Product Chemistry Data...for 67-33: Update (to theManufacturing Process). Unpublished study prepared by Great Lakes Chemical Corp. 8 p.

Agency Memoranda Citations

DP Barcode(s): D182763Subject: Chloropicrin Reregistration. LCP Chemicals Response to the DCI dated

9/28/90: Product Chemistry Guidelines 61-2 through 63-13 (Case No.0040, Chemical No. 081501)

From: A. AikensTo: L. Rossi/K. SamekDated: 12/29/92MRID(s): 42400001, 42400002, and 42427001

20

DP Barcode(s): D197238Subject: Chloropicrin Reregistration. List A Chemical No. 081501; Case No.

0040. Chloropicrin Manufacturers Task Force: Response to DCI DataRequirements Regarding Octanol/Water Partition Coefficient (Guideline#63-11).

From: F. ToghrolTo: L. Rossi/L. SchnaubeltDated: 3/29/94MRID(s): 43022402


0040. Trinity Manufacturing, Inc. Response to DCI Data RequirementsRegarding Guideline Series 62 and 63.

From: F. ToghrolTo: L. Rossi/L. SchnaubeltDated: 5/26/94MRID(s): 43137001 and 43137002


0040. Ashta Chemicals Inc.: Response to DCI Data RequirementsRegarding Guideline Series 63.


DP Barcode(s): D202606 and D204276Subject: Chloropicrin Reregistration. List A Chemical No. 081501; Case No.

0040. Chloropicrin Manufacturers Task Force Response RegardingSuitability of a Composite TGAI.


DP Barcode(s): D199152 and D198927Subject: Chloropicrin. Product Chemistry - Niklor. Reregistration Case No. 0040

Chemical No. 081501.From: S. KniznerTo: S. JenningsDated: 7/12/94MRID(s): 43097901, 43097902, 43090201, and 43090202

21

DP Barcode(s): D198923Subject: Chloropicrin. Product Chemistry - Ashta Chemicals. Reregistration Case

No. 0040 Chemical No. 081501.From: S. KniznerTo: S. JenningsDated: 7/12/94MRID(s): 43091401 and 43091402

DP Barcode(s): D198925Subject: Chloropicrin. Product Chemistry - Trinity Manufacturing. Reregistration

Case No. 0040 Chemical No. 081501.From: S. KniznerTo: S. JenningsDated: 7/12/94MRID(s): 43091301

DP Barcode(s): D211265Subject: Chloropicrin: Review of Product Chemistry (Subdivision D), GLNs 61 to

63.From: S. KniznerTo: A. Rathman/F. SuhreDated: 5/8/95MRID(s): 43434601

DP Barcode(s): D213751Subject: Chloropicrin: Review of Product Chemistry (Subdivision D), GLNs 61 to

63.From: S. KniznerTo: A. Rathman/F. SuhreDated: 5/8/95MRID(s): None

DP Barcode(s): RD Memorandum D234151Subject: MP Product Chemistry Review. Reg. No. 5785-52. Product Name:

67-33. Company: Great Lakes Chem Corp.From: A. SmithTo: K. SwiftDated: 7/1/97MRID(s): 44230001

memorandum chloropicrin. chemistry chapter for the

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