members of the temperature module: t. dziedzic (poland), p. michel (switzerland), v. papavasileiou...
TRANSCRIPT
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Members of the temperature module: T. Dziedzic (Poland), P. Michel (Switzerland), V. Papavasileiou (Greece), J. Petersson (Sweden), D. Staykov (Germany).
Chairs of the ESO guidelines committee: J. Mas (France), T. Steiner (Germany).
Nice, ESC2014
ESO Guidelines: Temperature management in acute ischaemic stroke
George Ntaios MD, MSc (ESO Stroke Medicine), PhD, FESO
University of Thessaly, Larissa, Greece
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Disclosures
Scholarships: European Stroke Organization; Hellenic Society of Atherosclerosis.Honoraria: Medtronic; Quintiles; CHUV; Belgian Stroke Council.Speaker fees: Sanofi; Boehringer-Ingelheim.Consultant fees: Boehringer-Ingelheim.Support to attend conferences: Bayer; Sanofi-Aventis; Pfizer; Lundbeck; Boehringer-Ingelheim; Galenica; Elpen; Bristol Myers Squibb. Participation in trials:
– ENOS / National coordinator. (Greece)– BPREVISE / Principal investigator.– FOURIER / Sub-investigator.– GLORIA / Sub-investigator .
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Population Hyperthermic patients with acute ischemic stroke
Intervention Treatment of hyperthermia
Comparator No treatment
Outcome Functional outcome / Mortality
PICO1
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1. cerebrovascular disorders/ or basal ganglia cerebrovascular disease/ or brain ischemia/ or exp brain infarction/ or hypoxia-ischemia, brain/ or carotid artery diseases/ or carotid artery thrombosis/ or carotid artery, internal, dissection/ or intracranial arterial diseases/ or cerebral arterial diseases/ or infarction, anterior cerebral artery/ or infarction, middle cerebral artery/ or infarction, posterior cerebral artery/ or exp "intracranial embolism and thrombosis"/ or exp stroke/ or vertebral artery dissection/2. (isch?emi$ adj6 (stroke$ or apoplex$ or cerebral vasc$ or cerebrovasc$ or cva or attack$)).tw.3. ((brain or cerebr$ or cerebell$ or vertebrobasil$ or hemispher$ or intracran$ or intracerebral or infratentorial or supratentorial or middle cerebr$ or mca$ or anterior circulation or basilar artery or vertebral artery) adj5 (isch?emi$ or infarct$ or thrombo$ or emboli$ or occlus$ or hypoxi$)).tw.4. 1 or 2 or 35. Fever/6. body temperature/7. (fever$ or hyperthermi$ or pyrexi$).tw.8. (temperature$ adj5 (high$ or rise or raised or elevated or change$ or fluctuat$)).tw.9. 5 or 6 or 7 or 810. Hypothermia, induced/11. cryotherapy/ or body temperature regulation/12. cold temperature/ or ice/ or extreme cold/13. exp antipyretics/ or exp Anti-Inflammatory Agents, Non-Steroidal/ or exp steroids/ or exp adrenal cortex hormones/14. acetaminophen/ or aspirin/ or diflunisal/ or ibuprofen/ or dipyrone/ or diclofenac/ or ketoprofen/ or naproxen/ or flurbiprofen/ or indomethacin/ or tolmetin/ or sulindac/ or etodolac/ or ketorolac/ or piroxicam/ or mefenamic acid/ or meclofenamic acid/ or flufenamic acid/ or prednisolone/ or prednisone/ or cortisone/ or hydrocortisone/ or methylprednisolone/ or dexamethasone/15. (fever$ adj3 (control$ or manage$)).tw.16. (hypothermi$ adj5 (therapeutic or artificial or induced or induction or intentional or therap$ or process or protocol$ or protective or cap or caps or helmet$ or scalp)).tw.17. (temperature$ adj5 (lower$ or low or decreas$ or reduc$ or normal or control$ or management)).tw.18. normothermi$.tw.19. ((cool or cold) adj5 (therap$ or temperature$ or device$ or equipment or fluid or catheter$ or bath$)).tw.20. (cryother$ or cryogen$ or cryotreat$).tw.21. (cooling or cooled or chilling or chilled or cools or coolcap or coolant or ice or icepack$ or cold water or iced water or water blanket or sponging or bathing or fan or fanning or coolgard).tw.22. ((cool or cold) adj5 (blanket$ or collar or helmet or hood)).tw.23. (antipyretic$ or anti-pyretic$ or antifebril$ or anti-febril$ or antiinflammatory or anti-inflammatory or NSAID$ or steroid$ or corticosteroid$ or glucocorticoid$ or corticoid$ or adrenal cortex hormone$ or acetaminophen or paracetamol or aspirin or acetylsalicylic acid or acetyl salicylic acid or ibuprofen or metamizole or dipyrone or diclofenac or ketoprofen or diflunisal or salsalate or naproxen or fenoproxen or dexketoprofen or flurbiprofen or oxaprozin or loxoprofen or indomethacin or tolmetin or sulindac or etodolac or ketorolac or aceclofenac or piroxicam or meloxicam or tenoxicam or droxicam or lornoxicam or isoxicam or mefenamic acid or meclofenamic acid or flufenamic acid or tolfenamic acid or celecoxib or rofecoxib or valdecoxib or parecoxib or lumiracoxib or etoricoxib or firocoxib or nimesulide or licofelone or prednisolone or prednisone or cortisone or cortisol or hydrocortisone or methylprednisolone or dexamethasone).tw.24. or/10-2325. 4 and 9 and 2426. Fever/dt, th [Drug Therapy, Therapy]27. 4 and 2628. 25 or 2729. exp animals/ not humans.sh.30. 28 not 2931. heat stroke/ or heat stroke.tw.32. 30 not 31
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PICO1
Potentially relevant papers identified and screened for retrievaln=3501
Studies excluded during initial screeningn=3347
Studies retrieved for more detailed evaluationn=154
Studies excluded during detailed evaluationn=151
Studies included in the meta-analysisn=3
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PICO1 – functional outcome
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PICO1 – functional outcome
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Population Hyperthermic patients with acute ischemic stroke
Intervention Treatment of hyperthermia
Comparator No treatment
Outcome Mortality
PICO1 - mortality
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PICO1 - mortality
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PICO1 - mortality
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PICO1 – Grade Evidence Profile
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PICO1 – Recommendations
Due to the very low quality of current evidence,
no specific recommendation can be made
about the usefulness of treatment of hyperthermia
to improve functional outcome or decrease mortality
in hyperthermic patients with acute ischaemic stroke.
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Population Normothermic patients with acute ischemic stroke
Intervention Prevention of hyperthermia
Comparator No treatment
Outcome Functional outcome / Mortality
PICO2
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1. cerebrovascular disorders/ or basal ganglia cerebrovascular disease/ or brain ischemia/ or exp brain infarction/ or hypoxia-ischemia, brain/ or carotid artery diseases/ or carotid artery thrombosis/ or carotid artery, internal, dissection/ or intracranial arterial diseases/ or cerebral arterial diseases/ or infarction, anterior cerebral artery/ or infarction, middle cerebral artery/ or infarction, posterior cerebral artery/ or exp "intracranial embolism and thrombosis"/ or exp stroke/ or vertebral artery dissection/2. (isch?emi$ adj6 (stroke$ or apoplex$ or cerebral vasc$ or cerebrovasc$ or cva or attack$)).tw.3. ((brain or cerebr$ or cerebell$ or vertebrobasil$ or hemispher$ or intracran$ or intracerebral or infratentorial or supratentorial or middle cerebr$ or mca$ or anterior circulation or basilar artery or vertebral artery) adj5 (isch?emi$ or infarct$ or thrombo$ or emboli$ or occlus$ or hypoxi$)).tw.4. 1 or 2 or 35. fever/pc6. (normothermia or normothermic or afebrile or without fever or no fever).tw.7. ((fever$ or hyperthermi$ or pyrexi$) adj5 (prevent$ or prophylaxis or prophylactic or protect$)).tw.8. (temperature$ adj5 (high$ or rise or raised or elevated or change$ or fluctuat$) adj5 (prevent$ or prophylaxis or prophylactic or protect$)).tw.9. ((maintain or maintenance) adj5 (normothermi$ or (normal adj3 temperature))).tw.10. fever/ and (prevent$ or prophylaxis or prophylactic or protect$).tw.11. 5 or 6 or 7 or 8 or 9 or 1012. Hypothermia, induced/13. cryotherapy/ or body temperature regulation/14. cold temperature/ or ice/ or extreme cold/15. exp antipyretics/ or exp Anti-Inflammatory Agents, Non-Steroidal/ or exp steroids/ or exp adrenal cortex hormones/16. acetaminophen/ or aspirin/ or diflunisal/ or ibuprofen/ or dipyrone/ or diclofenac/ or ketoprofen/ or naproxen/ or flurbiprofen/ or indomethacin/ or tolmetin/ or sulindac/ or etodolac/ or ketorolac/ or piroxicam/ or mefenamic acid/ or meclofenamic acid/ or flufenamic acid/ or prednisolone/ or prednisone/ or cortisone/ or hydrocortisone/ or methylprednisolone/ or dexamethasone/17. (hypothermi$ adj5 (therapeutic or artificial or induced or induction or intentional or therap$ or process or protocol$ or protective or cap or caps or helmet$ or scalp)).tw.18. (temperature$ adj5 (lower$ or low or decreas$ or reduc$ or control$ or manage$ or monitor$)).tw.19. ((cool or cold) adj5 (therap$ or temperature$ or device$ or equipment or fluid or catheter$ or bath$)).tw.20. (cryother$ or cryogen$ or cryotreat$).tw.21. (cooling or cooled or chilling or chilled or cools or coolcap or coolant or ice or icepack$ or cold water or iced water or water blanket or sponging or bathing or fan or fanning or coolgard).tw.22. ((cool or cold) adj5 (blanket$ or collar or helmet or hood)).tw.23. (antipyretic$ or anti-pyretic$ or antifebril$ or anti-febril$ or antiinflammatory or anti-inflammatory or NSAID$ or steroid$ or corticosteroid$ or glucocorticoid$ or corticoid$ or adrenal cortex hormone$ or acetaminophen or paracetamol or aspirin or acetylsalicylic acid or acetyl salicylic acid or ibuprofen or metamizole or dipyrone or diclofenac or ketoprofen or diflunisal or salsalate or naproxen or fenoproxen or dexketoprofen or flurbiprofen or oxaprozin or loxoprofen or indomethacin or tolmetin or sulindac or etodolac or ketorolac or aceclofenac or piroxicam or meloxicam or tenoxicam or droxicam or lornoxicam or isoxicam or mefenamic acid or meclofenamic acid or flufenamic acid or tolfenamic acid or celecoxib or rofecoxib or valdecoxib or parecoxib or lumiracoxib or etoricoxib or firocoxib or nimesulide or licofelone or prednisolone or prednisone or cortisone or cortisol or hydrocortisone or methylprednisolone or dexamethasone).tw.24. or/12-2325. 4 and 11 and 2426. *Fever/pc and 427. 25 or 2628. exp animals/ not humans.sh.29. 27 not 2830. heat stroke/ or heat stroke.tw.31. 29 not 3032. (neonat$ or newborn$ or new born or pediatric or paediatric or birth or infant or infants or perinatal or peri-natal or baby or babies or child or children).ti33. 31 not 32
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PICO2
Potentially relevant papers identified and screened for retrievaln=833
Studies excluded during initial screeningn=820
Studies retrieved for more detailed evaluationn=13
Studies excluded during detailed evaluationn=9
Studies included in the meta-analysisn=4
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PICO2 – functional outcome
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PICO2 – functional outcome
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Population Normothermic patients with acute ischemic stroke
Intervention Prevention of hyperthermia
Comparator No treatment
Outcome Mortality
PICO2
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PICO2 - mortality
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PICO2 - mortality
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PICO2 - Grade Evidence Profile
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PICO2 – Recommendations
We recommend against the prevention of hyperthermia as a
means to improve functional outcome in normothermic
patients with acute ischaemic stroke.
Due to the very low quality of current evidence, no specific
recommendation can be made for the usefulness of the
prevention of hyperthermia to reduce mortality in
normothermic patients with acute ischaemic stroke.
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Population Patients with acute ischemic stroke
Intervention Induction of hypothermia
Comparator No intervention
Outcome Functional outcome / Mortality
PICO3
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1. cerebrovascular disorders/ or basal ganglia cerebrovascular disease/ or brain ischemia/ or exp brain infarction/ or hypoxia-ischemia, brain/ or carotid artery diseases/ or carotid artery thrombosis/ or carotid artery, internal, dissection/ or intracranial arterial diseases/ or cerebral arterial diseases/ or infarction, anterior cerebral artery/ or infarction, middle cerebral artery/ or infarction, posterior cerebral artery/ or exp "intracranial embolism and thrombosis"/ or exp stroke/ or vertebral artery dissection/2. (isch?emi$ adj6 (stroke$ or apoplex$ or cerebral vasc$ or cerebrovasc$ or cva or attack$)).tw.3. ((brain or cerebr$ or cerebell$ or vertebrobasil$ or hemispher$ or intracran$ or intracerebral or infratentorial or supratentorial or middle cerebr$ or mca$ or anterior circulation or basilar artery or vertebral artery) adj5 (isch?emi$ or infarct$ or thrombo$ or emboli$ or occlus$ or hypoxi$)).tw.4. 1 or 2 or 35. Hypothermia, induced/6. cryotherapy/7. cold temperature/ or ice/ or extreme cold/ or shivering/8. (hypothermi$ adj5 (therapeutic or artificial or induce or induced or induction or intentional or therap$ or process or protocol$ or protective or neuroprotect$ or cap or caps or helmet$ or scalp)).tw.9. hypothermia/ and (therapeutic or artificial or induce or induced or induction or intentional or therap$ or process or protocol$ or protective or neuroprotect$ or cap or caps or helmet$ or scalp).tw.10. (temperature$ adj5 (lower$ or decreas$ or reduc$ or drop$)).tw.11. body temperature/ or temperature/ or skin temperature/12. (lower$ or decreas$ or reduc$ or drop$).tw.13. 11 and 1214. ((cool or cold or ice-cold) adj5 (therap$ or temperature$ or device$ or equipment or fluid or catheter$ or bath$ or air)).tw.15. (cryother$ or cryogen$ or cryotreat$ or shiver$).tw.16. (cooling or cooled or chilling or chilled or cools or coolcap or coolant or ice or icepack$ or cold water or iced water or water blanket or sponging or bathing or fan or fanning or coolgard).tw.17. ((cool or cold or ice-cold) adj5 (blanket$ or collar or helmet or hood)).tw.18. 5 or 6 or 7 or 8 or 9 or 10 or 13 or 14 or 15 or 16 or 1719. 4 and 1820. exp animals/ not humans.sh.21. 19 not 2022. heat stroke/ or heat stroke.tw.23. 21 not 2224. (neonat$ or newborn$ or new born or pediatric or paediatric or birth or infant or infants or perinatal or peri-natal or baby or babies or child or children).ti.25. 23 not 24
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PICO3
Potentially relevant papers identified and screened for retrievaln=4790
Studies excluded during initial screeningn=4729
Studies retrieved for more detailed evaluationn=61
Studies excluded during detailed evaluationn=55
Studies included in the meta-analysisn=6
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PICO3 – functional outcome
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PICO3 – functional outcome
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Population Patients with acute ischemic stroke
Intervention Induction of hypothermia
Comparator No intervention
Outcome Mortality
PICO3
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PICO3 - mortality
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PICO3 - mortality
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PICO3 - Grade Evidence Profile
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PICO3 – Recommendations
Due to the low quality of current evidence, no specific
recommendation can be made about the usefulness of induced
hypothermia in patients with acute ischaemic stroke.
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PICO 1-3 – Recommendations
For all the above questions where evidence is insufficient,
we encourage the recruitment of patients in randomized
controlled trials.
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