medinvents’ concept and products. click to edit master title style molecular biology medinvents...

MedInvents’ concept and products

Click to edit Master title style

Molecular biology

MedInvents Concepts and Products

MedInvents Applications and Markets

Effects of Vitamin C and Vitamin K3 Treatment on Human Tumor Cell Growth In Vitro 1. Synergism of Combined Vitamin C and K3 ActionVINCENZO NOTO, MD,* HENRYK S. TAPER, MD,t JIANG YI-HUA, MD,*’$ JAAK JANSSENS, MD,§ JAN

BONTE, MD,§ AND WILLIAM DE LOECKER, MD’

Cancer 63:901-906, 1989.

Effects of Sodium Ascorbate (Vitamin C) and 2-Methyl- 1,4- Naphthoquinone (Vitamin K3) treatment on Human Tumor Cell Growth In Vitro 2. Synergism with combined chemotherapy action.De Loecker, W : Janssens, J : Bonte, J : Taper, H S Anticancer Research 1993; 13: 103-6.

J Ph Janssens, I Russo, J Russo, J Breitmeyer, M LopezBresnahan.Inhibitory effect of recombinant human chorionic gonadotropin (rhCG) in metastatic breast cancer in postmenopausal women. Biopsy before and after treatment.Monographs of the National Cancer Institute, 2000.

Agendia

TiGenix

MasterGenix

Diagenode

Morphology

Biochemistry

Molecular biology

Click to edit Master title styleMedInvents’ concept

Personalized Medicine• Cytostatics• Hormones• Growth inhibitors• Monoclonal antibodies…

Personalized Diagnostics• Pathology• Immuno-histochemistry• Molecular biology…

Macrobiopsy•Enough tissue•Representative tissue• Fresh

Implementing clinical use of personalized diagnostics can stratify patients, give molecular classification of disease, determine the likelihood of occurrence, and recommend the best course of treatment. These approaches promise to reduce costs in healthcare,improve treatment, and have the potential to provide consumer-driven access to health information. But how will we acquire tissue to fulfill all these opportunities ? Cambridge Healthtech Institute


Anno 2011

Jaak Ph. Janssens New Direct and Frontal Tissue Acquisition Tools for Gene Expression Analysis. Current Pharmacogenomics & Personalized Medicine 2010; 8: 37-48

Powerful weapon

But where is the

monition ?

Bench Tissue acquistionRepresentativityPatient comfortCostsAccess

Bed

Reimbursement

Pharmaceutical Industry

Burden

Institution

Tradition…

Obstacles for translational research

7

MedInvents’ technology superiority

1. Innovative technology2. Right in time for the

market3. Safety & Comfort4. Accuracy5. Product portfolio6. Strong science7. Patents & certificate8. Consistency9. Next generation

applications

• Direct & Frontal• Macrobiopsy• All soft tissues• Easy procedure• Less invasive



market3. Safety & Comfort4. Accuracy5. Product portfolio6. Strong science7. Patents & certificates8. Consistency9. Next generation

applications

Jaak Ph. Janssens New Direct and Frontal Tissue Acquisition Tools for Gene Expression Analysis. Current Pharmacogenomics & Personalized Medicine 2010; 8: 37-48

Molecular biology




applications

Ann Cornelis, Marcel Verjans, Thierry Van den Bosch, Katrien Wouters, Johan Van Robaeys, Jaak Ph. Janssens & Working Group on Hormone Dependent Cancers, The European Cancer Prevention Organization. Efficacy and safety of direct and frontal macrobiopsies in breast cancer. Eur J Cancer Prev 2009 ; 18 : 280 – 4.




applications

Harries R, Lawson S, Bruckers Liesbeth. Assessment of microcalcifications with limited number of high-precision macrobiopsies. Eur J Cancer Prev 2010; 19: 374-8.




applications

Gielen JL, De Schepper AM, Blom R, Van Dyck P, Bosmans JML, Creytens DH, Veryser J, Somville J, Parizel PM. Experience with a novel frontal core biopsy device in soft tissue and bone lesions.Skeletal Radiol 2011; 40 In press – Published online.




applications




applicationsM, Barbaret V, Chiers K, Duchateau L, Bacci B, Terragni R, Rossi F, Sounders JH. Evaluation of a manual biopsy device («Spirotome ») on fresh canine organs : liver, spleen and kidneys and first clinical experience in animals. Eur J Cancer Prev 2010; 20:: 140-5.



market3. Safety & Comfort4. Accuracy5. Product portfolio6. Strong science7. Patents & certificate8. Consistency9. Next generation

applications

Ter Brugge H. Laparoscopic staging with a new direct and frontal biopsy instrument. J Gynecologic Surgery 2010; in press.




applications

• Proprietary technology• ISO 9001-2008• ISO 13485• FDA (13 applications)• Reimbursement

• Several applications• Several countries




applications

Mirror sampling

Creation of mirror samples:

• Pathology: • Formaldehyde 5%

• Molecular biology: • RNALater

• Biobanking:• RNALater

• Deps control

Tru-cut D & F VAB Surgery

Representativity No Yes Yes Yes

Comfort Yes Yes No No

Costs Yes Yes No No

Access Yes Yes No Yes

Tissue quantity per sample 15-20 mg 200-300 mg 150-200 mg NA

Border disruption Mild Mild Extensive NA

21

Tissue acquisition for translational research

Medinvents’ Products

• Automated version • Handheld or stereotactically positioned• Reusable handle controller, disposable

8 – 10 Gauge needles• Vacuum assisted system• Multiple samples without reinserting

• A range of large core soft tissue biopsy needles• Based on NEW double rota-cutting technique• 8 – 14 Gauge• Vacuum system on Single Use

Product portfolio:• Spirotome Single Use/Reusable• Spirotome Cervicore ™• Spirotome MRI ™• Spirotome Bone ™• Spirotome Easy Punch ™

http://www.medinvents.com/spirotome.html

http://www.medinvents.com/coramate.html

Medinvents’ ApplicationsCoramate ™• Breast• Thyroid• Salivary glands• Thoracic wall• Abdominal wall• Lymph nodes• Muscle

Spirotome™• Breast• Thyroid• Salivary glands• Thoracic wall• Abdominal wall• Lymph nodes• Muscle• Liver

Spirotome Cervicore ™• Cervix• Uterus

Spirotome Easy Punch ™• Skin• Vulva

Spirotome Bone ™• Soft tissues within bone

Spirotome Endo ™• Laparoscopy (type ter Brugge)• Uterus (type Campo)

Spirotome Neuro ™• Brain

Spirotome Spine ™• Soft tissues within bone












OncologyAnimal healthGynecologyInfertilityPharmacological researchRegenerative medicine

◦ Myocardial infarct◦ Urinary incontinency◦ Knee orthopedics

Revalidation medicine

MedInvents’ application domains

Click to edit Master title styleMedInvents’ in Gynecology

HTB 2010

Uterus Diepe myometriale biopsies zijn nu mogelijk met de Spirotome Endo als staging ofwel om pathologische processen aan te tonen.

Ovarium Subcorticale ovariumbiopsies bij jonge vrouwen levert eicellen of follikels op die kunnen bewaard worden voor latere fertilisatie. De Spirotome Endo is hiervoor geschikt.

Myoma uteri In vele centra wordt HIFU (high intensity focused ultrasound) gebruikt als behandeling. Maar ongeveer 1-2 % van deze goedaardige gezwellen zijn toch kwaadaardig (sarcomen). Om te voorkomen dat sarcomen foutief zouden behandeld worden (door heelkunde) is een D&F biopsie nodig voor HIFU.

Peritoneum Laparoscopische exploratie van het abdomen kan reeds oppervlakkige biopsies nemen. Met de Spirotome Endo zijn nu ook diepe biopsies mogelijk.

Click to edit Master title styleMedinvents’ Clinicians

Belgium

International

- Prof. Gielen; Antwerpen- Dr. Verjans; Tienen- Prof. Lifrange; Liège- Dr. Steyaert; Brugge- Dr. De Jonge; Genk- Prof. Vergote; Leuven- Prof. Kridelka; Liège- Prof. Cusumano; Liège- Prof. Bogers; Antwerpen- Dr. Naudts; Antwerpen- Dr. Van Wiemeersch; Antwerpen- Dr. Coppens; Geel- Dr. Schraepen; Brussel- Dr. Michielsen; Antwerpen- Dr. Opdenakker; Hasselt- Dr. Weyers; Gent- Dr. Cornelis; Tienen- Dr. Campo; Leuven- Dr. DeGryse; Ieper- Dr. De Vlaeminck; Torhout- ….

- Prof. Petignat; Switserland- Dr. Harries; UK- Dr. Rotenberg; France- Dr. Chersevani; Italy- Prof. Schulz-Wendtland; Germany- Prof. Polkowski; Poland- Prof. Russo; USA- Prof. Nickers; France- Prof. Cabula; Sardinia - Dr. Feydi; France- Prof. Laredo; France- Dr. Sentis; Spain- Prof. Palussière; France- Dr. ter Brugge; The Netherlands- Dr. Dijkstra; The Netherlands- Dr. Mendoza; Peru- Dr. Murta; Brasil- Prof. Adapon; Philippines- Dr. Yespica; USA- ….


Dear Sir,I have had the opportunity to use the Spirotome in clinical cases and have been very impressed with the level of control and safety, ease of use, and high quality of samples obtained. My pathologist in the college has examined these samples and was likewise impressed with the high quality of diagnostic information obtainable and lack of crushing artifact as sometimes occurs with other systems such as the Tru-Cut style system.

Dr. MB, Knoxville, TN 2010

What colleagues say:

Medinvents’ Device R&D

”Coramate M7” Prototype ready for clinical testingIWT supported project

We will continue to develop in the spirit of innovative products, “simple, useful and patient friendly”

Continuous input from physicians will have an impact on the development

Sales Business Opportunities

Interventional radiology• Breast• Thyroid• Head & Neck• Lymph node• Lung• Liver• Kidney• Muscle• Bone• Vertebroplasty

• Women’s Health• Vulva• Cervix• Hysteroscopy• Laparoscopy

• Surgery• Skin• Laparoscopy• Bronchoscopy• Prostate• Neurosurgery• Bone Drill

• Cell transplantation• Muscle• Chondroblast

regeneration• Animal Health

MedInvent’s technology opportunities:

medinvents’ concept and products. click to edit master title style molecular biology medinvents...

Documents

md cancer

jaak janssens

j ph janssens

janssens new direct

j russo

j breitmeyer

eur j cancer prev

metastatic breast cancer