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report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails2jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=3Page 3button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=3 data-page=3 class=ts-thumb lazyload alt=Page 3: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails16jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=17Page 17button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=17 data-page=17 class=ts-thumb lazyload alt=Page 17: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails17jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails19jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=20Page 20button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=20 data-page=20 class=ts-thumb lazyload alt=Page 20: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails23jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=24Page 24button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=24 data-page=24 class=ts-thumb lazyload alt=Page 24: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails24jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails26jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=27Page 27button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=27 data-page=27 class=ts-thumb lazyload alt=Page 27: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails30jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=31Page 31button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=31 data-page=31 class=ts-thumb lazyload alt=Page 31: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails31jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails33jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=34Page 34button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=34 data-page=34 class=ts-thumb lazyload alt=Page 34: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails37jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=38Page 38button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=38 data-page=38 class=ts-thumb lazyload alt=Page 38: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails38jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails40jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=41Page 41button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=41 data-page=41 class=ts-thumb lazyload alt=Page 41: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails44jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=45Page 45button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=45 data-page=45 class=ts-thumb lazyload alt=Page 45: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails45jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails47jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=48Page 48button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=48 data-page=48 class=ts-thumb lazyload alt=Page 48: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails51jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=52Page 52button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=52 data-page=52 class=ts-thumb lazyload alt=Page 52: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails52jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails54jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=55Page 55button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=55 data-page=55 class=ts-thumb lazyload alt=Page 55: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails58jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=59Page 59button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=59 data-page=59 class=ts-thumb lazyload alt=Page 59: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails59jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails61jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=62Page 62button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=62 data-page=62 class=ts-thumb lazyload alt=Page 62: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails65jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=66Page 66button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=66 data-page=66 class=ts-thumb lazyload alt=Page 66: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails66jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails68jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=69Page 69button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=69 data-page=69 class=ts-thumb lazyload alt=Page 69: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails72jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=73Page 73button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=73 data-page=73 class=ts-thumb lazyload alt=Page 73: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails73jpg width=140 height=200 divdivdiv 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history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails79jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=80Page 80button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=80 data-page=80 class=ts-thumb lazyload alt=Page 80: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails80jpg width=140 height=200 divdivdiv 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of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC data-src=https:reader033vdocumentsusreader033viewer20220502065f59dcd3659b6574580e0488html5thumbnails82jpg width=140 height=200 divdivdiv class=ts-pagebutton class=gotoPage data-page=83Page 83button div class=ts-imageimg data-url=mdl-2179-trial-2-the-events-discussed-in-the-background-section-of-this-report-contamhtmlpage=83 data-page=83 class=ts-thumb lazyload alt=Page 83: MDL 2179 Trial Docs€¦ · 2 The events discussed in the Background section of this report contam no opinions and are not intended to represent an exhaustive history of all important loading=lazy src=data:imagegifbase64iVBORw0KGgoAAAANSUhEUgAAAAIAAAACCAQAAADYv8WvAAAAD0lEQVR42mP8X8AwAgiABKBAv+vAXklAAAAAElFTkSuQmCC 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