1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 VLP TTx PHA0.0

2.5

5.0

7.5

10.0400

950

1500

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 MOGVLP TTx PHA0.0

2.5

5.0

7.5

10.0

500

1000

1500

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 MBP VLP TTx PHA0.0

2.5

5.0

7.5

10.0

500

1000

1500

MBP Peptides

MOG Peptides

PLP Peptides

MBP

MOG

PLP

Supplementary Figure 8