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1 ©2017 Philips Innovation Services | Confidential May 8-9, 2017 Polymer Replication on Nanoscale conference, Aachen René Sanders Manufacturing of shims for m icrofluidics

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1 ©2017 Philips Innovation Services | Confidential

May 8-9, 2017

Polymer Replication on Nanoscale conference, AachenRené Sanders

Manufacturing of shims for microfluidics

2 ©2017 Philips Innovation Services | Confidential

Structure

• Introduction– PInS– Eniac MFM project

• Process flow descrition– Laser ablation– Injection moulding

• Example uF

• Summary and conclusions

3 ©2017 Philips Innovation Services | Confidential

Philips Innovation Services: a short introduction

5 ©2017 Philips Innovation Services | Confidential

ENIAC project: MFManufacturing

European initiative for the standardization and manufacturability of complex microfluidic (MF) devices

6 ©2017 Philips Innovation Services | Confidential

Exemplary fluidic functions

Name Picture Description

Capillary pump Array of pillars increases capillary force. Channel width 450 µm, depth 50 µm. 40 µm pillars at 150 µm pitch.

Mixer Channel filled with small ribs enhances mixing. Total channel length 160 mm, channel depth = 170 µm, rib height 30 µm.

Standardization = 15x15x1 mm3, fixed in- and outlet dimensions and positions

7 ©2017 Philips Innovation Services | Confidential

Process flow schematic

Polycarbonate master Nickel shim Injection moulded COP part

Dicing into individual partsLaser ablation of uF structures

8 ©2017 Philips Innovation Services | Confidential

Accurate removal of large polymer surface area: 0.01 micron per pulse, mm’s area

Laser ablation with excimer laser

9 ©2017 Philips Innovation Services | Confidential

Results capillairy pump: ablated structure in PC

design

0.80.6 mm

Height measurement

10 ©2017 Philips Innovation Services | Confidential

Mixer

channel rib structure

11 ©2017 Philips Innovation Services | Confidential

12 ©2017 Philips Innovation Services | Confidential

13 ©2017 Philips Innovation Services | Confidential

14 ©2017 Philips Innovation Services | Confidential

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17 ©2017 Philips Innovation Services | Confidential

Microfluidic mixing channel: height measurement

18 ©2017 Philips Innovation Services | Confidential

19 ©2017 Philips Innovation Services | Confidential

Injection moulding by Axxicon

20 ©2017 Philips Innovation Services | Confidential

21 ©2017 Philips Innovation Services | Confidential

22 ©2017 Philips Innovation Services | Confidential

Results capillairy pump

23 ©2017 Philips Innovation Services | Confidential

Functional test capillairy pumpTime laps series of capillairy pump working

• 2 seconds per image

24 ©2017 Philips Innovation Services | Confidential

Functional test microfluidic mixing channel

25 ©2017 Philips Innovation Services | Confidential

Summary and guidelines

Item Master excimer

Material Polycarbonate

Workpiece Flat sheet

Draft-angle ~10..15 degrees

Channel depth < 100 microns

Surface roughness 0.05 micron

XY accuracy ± 1 micron

Z-accuracy 0.03 micron

26 ©2017 Philips Innovation Services | Confidential

Acknowledgments

Philips• Thomas de Boer• Robbert van der Waal• Hans van der Schaft• Jo Cuppens• Ben Beerling• Leandra Vermeulen• Maartje van der Zalm• Maurice van der Beek• Peter Bouma

Axxicon• Dirk Verhoeven• Tim van Kampen

“This work was supported by ENIAC Joint Undertaking (JU) under the grant

agreement number 621275”.

28 ©2017 Philips Innovation Services | Confidential