MAKING ADNI MAKING ADNI METHODS AVAILABLE METHODS AVAILABLE

TO ADCTO ADC’’ssMike Weiner, UCSFMike Weiner, UCSFClifford Jack, MayoClifford Jack, Mayo

Art Toga, UCLAArt Toga, UCLAAnd the other ADNI investigatorsAnd the other ADNI investigators

WHAT HAS ADNI WHAT HAS ADNI ACCOMPLISHED?ACCOMPLISHED?

Goals of ADNI are to:Goals of ADNI are to:Improve imaging and biomarker methods for trialsImprove imaging and biomarker methods for trialsDevelop standardized methodsDevelop standardized methodsIdentify the optimum biomarkers for TrialsIdentify the optimum biomarkers for Trials

Thus far the following has been accomplishedThus far the following has been accomplishedStandardized methods for acquiring MRI and PET, Standardized methods for acquiring MRI and PET, using phantoms to improve quality, are using phantoms to improve quality, are implementedimplemented

A webA web--based image repository has been based image repository has been establishedestablished

WE WISH TO MAKE ADNI METHODS WE WISH TO MAKE ADNI METHODS AND INFRASTRUCTURE AND INFRASTRUCTURE

AVAILABLE TO ADCSAVAILABLE TO ADCSOur goal today is to inform you of our methods and Our goal today is to inform you of our methods and infrastructure, and begin to develop a plan to make infrastructure, and begin to develop a plan to make this available to youthis available to youFirst we will present these methodsFirst we will present these methodsSecond we want to hear from youSecond we want to hear from youThird, depending on level of interest, we will work to Third, depending on level of interest, we will work to develop a plan to suit the needs of:develop a plan to suit the needs of:

Individual ADCsIndividual ADCsThe ADCs as a group, including the NACCThe ADCs as a group, including the NACC

MRI ACQUISITIONMRI ACQUISITION

Clifford Jack MDClifford Jack MDMayo ClinicMayo Clinic

ADNI MRI Services ADNI MRI Services

Site equipment survey – determine optimum scanner for individual siteDeliver platform specific protocol to sites – protocol would include agreed upon “basic “ set of images which could be expanded at sites discretionDistribute MR procedures manual to sitesTraining of MRI site personnel by ADNI MR techSite certification – phantom and/or human volunteer scansHands on trouble shooting by ADNI technical personal (iephysics, MR tech, radiologist)Organizing vendor support

ADNI MRI Services contADNI MRI Services cont’’d d

QA of patient images: visual + electronic inspection: 3 areas – protocol compliance, image quality, medical abnormalities (not legally binding interpretation)Quantitative image analysis: ROI-based – hippocampus, ERC, BSI; voxel-based – VBM, TBMMeasurer scanner stability – calibration phantom – notify site if deviation from specificationsModify original images off scanner to correct system specific non idealities: 3 categories - intensity, non-linearity, calibration drift

Correction of intensity non uniformityCorrection of intensity non uniformity

Data Flow for MRIData Flow for MRI

Analogous for PETScanning site LONILONI MayoAt Mayo: image QA; corrections of human and phantom data; phantom analysisCorrected human and phantom data Mayo LONIQA reports LONI

Alzheimer’s Disease Research Center (ADRC) Brain Imaging

Data Repository at LONIArthur W. Toga, Ph.D.

Successful Model for ADNISuccessful Model for ADNIAlzheimerAlzheimer’’s Disease Neuroimaging Initiative (ADNI)s Disease Neuroimaging Initiative (ADNI)

NIA sponsored program to obtain brain imaging data in AD NIA sponsored program to obtain brain imaging data in AD patientspatientsEstablished 2004 involving 60 institutionsEstablished 2004 involving 60 institutionsLONI participating as Neuroinformatics coreLONI participating as Neuroinformatics coreProvides database framework for all investigatorsProvides database framework for all investigatorsIn 2006 alone:In 2006 alone:

1,400 image series archived per month 1,400 image series archived per month 25,000 image series downloaded 25,000 image series downloaded

A portable and adaptable database modelA portable and adaptable database modelCan be customized and applied to similar federally funded Can be customized and applied to similar federally funded neuroimaging related programs for the study of the brain in neuroimaging related programs for the study of the brain in health and disease health and disease

Efficiently Migrate Data from Efficiently Migrate Data from ADRC Sites to LONIADRC Sites to LONI

The LONI IDAThe LONI IDA

Ease of data entry; ease of DB search

The LONI PipelineThe LONI Pipeline

ADRC researchers may incorporate their own software tools, utilizeLONI analysis methods, or utilize those from the community via the LONI Pipeline

Examine AD Brain Volumes in the Examine AD Brain Volumes in the LONI IDALONI IDA

OTHER IMAGING METHODSOTHER IMAGING METHODS

FDG PETFDG PETPIBPIBOthersOthers

SUMMARYSUMMARYADNI has developedADNI has developed

MRI acquisition methodsMRI acquisition methodsMRI image storage and MRI image storage and archiving capabilitiesarchiving capabilitiesA number of image A number of image processing methods are processing methods are being applied to ADNI databeing applied to ADNI data

HOW CAN ADNI HELP THE ADCs?HOW CAN ADNI HELP THE ADCs?

ADNI could provide the ADNI MRI sequences to be ADNI could provide the ADNI MRI sequences to be used at individual ADCs for nonused at individual ADCs for non--ADNI projectsADNI projectsADNI upload, storage, and processing methods could ADNI upload, storage, and processing methods could be available to ADCs for single or be available to ADCs for single or multisitemultisite studiesstudiesMethods used by ADNI could be available to such Methods used by ADNI could be available to such imagesimagesUltimately, it could be possible to work towards Ultimately, it could be possible to work towards uniform standards for imaging, enabling data poolinguniform standards for imaging, enabling data pooling

HOW CAN ADNI HELP THE ADCs?HOW CAN ADNI HELP THE ADCs?

WeWe’’d like to hear from you how ADNI d like to hear from you how ADNI methods and infrastructure could facilitate the methods and infrastructure could facilitate the work at your ADCwork at your ADCPlease give us your comments nowPlease give us your comments nowFollow up with comments questions and Follow up with comments questions and suggestions latersuggestions laterDepending on interest, we will develop a plan Depending on interest, we will develop a plan and come back to the ADCs and NIA in the and come back to the ADCs and NIA in the futurefuture