macrophages -alveolar macrophages in the lung -histiocytes in connective tissues -kupffer cells in...
TRANSCRIPT
![Page 1: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/1.jpg)
Macrophages
-Alveolar macrophages in the lung
-Histiocytes in connective tissues
-Kupffer cells in the liver
-Mesangial cells in the kidney
-Microglial cells in the brain
- Osteoclasts in bone
![Page 2: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/2.jpg)
Functions of Macrophages
- Phagocytosis
- Antimicrobial and cytotoxic activities
- Antigen processing and presentation
- Secretion of factors
![Page 3: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/3.jpg)
![Page 4: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/4.jpg)
![Page 5: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/5.jpg)
Granulocytic Cells(granulocytes)
- Neutrophils
- Eosinophils
- Basophils
![Page 6: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/6.jpg)
![Page 7: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/7.jpg)
![Page 8: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/8.jpg)
![Page 9: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/9.jpg)
Dendritic Cells
- Langerhans cells in the epidermis (skin) and mucous membranes
- Interstitial dendritic cells in organs
- Interdigitating dendritic cells in secondary lymphoid tissue
- Circulating dendritic cells in the blood
- Veiled cells in the lymph
![Page 10: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/10.jpg)
Development of Dendritic Cells
![Page 11: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/11.jpg)
Organs of the Immune System
![Page 12: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/12.jpg)
Primary (central) lymphoid organs- Provide appropriate microenvironments for the development and maturation of lymphocytes.
-thymus, bone marrow
Secondary (peripheral) lymphoid organs- Trap antigen from tissues or vascular spaces and are sites where mature lymphocytes can interact effectively with that antigen.
- lymph nodes, spleen, mucosal-associated lymphoid tissues (MALT), e.g., gut-associated lymphoid tissue (GALT).
![Page 13: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/13.jpg)
Tertiary lymphoid tissue - Cutaneous-associated lymphoid tissues
Lymphatic System (淋巴系統 )
- Once mature lymphocytes have been generated in the primary lymphoid organs, they circulate in the blood and lymphatic system, a network of vessels that collect fluid that has escaped into the tissues from capillaries of the circulatory system and ultimately return it to the blood.
![Page 14: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/14.jpg)
Lymphatic Vessels
![Page 15: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/15.jpg)
The Human Lymphoid Systemsecondary
primary
![Page 16: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/16.jpg)
The thymus
stromal cells:
m
aturation
![Page 17: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/17.jpg)
A Lymph Node (1)
![Page 18: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/18.jpg)
A Lymph Node (2)
![Page 19: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/19.jpg)
The Spleen
![Page 20: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/20.jpg)
The Spleen (1)
(血管神經出入口 )
![Page 21: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/21.jpg)
The Spleen (2)
![Page 22: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/22.jpg)
Mucosal-Associated lymphoid tissue (MALT)
TonsilsAppendixPeyer’s patches
- contain a large population of Ab-producing plasma cells
![Page 23: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/23.jpg)
Tonsils
(上顎 ) (舌 )
(咽 )
![Page 24: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/24.jpg)
Peyer’s Patch
contain intraepitheliallymphocytes IELs
B cells, plasma cell,activated TH cells & m
![Page 25: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/25.jpg)
Structure of M Cells
![Page 26: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/26.jpg)
Production of IgA Ab in the Gut
![Page 27: Macrophages -Alveolar macrophages in the lung -Histiocytes in connective tissues -Kupffer cells in the liver -Mesangial cells in the kidney -Microglial](https://reader035.vdocuments.us/reader035/viewer/2022062519/5697c0301a28abf838cdaf92/html5/thumbnails/27.jpg)
Cutaneous-associated Lymphoid Tissue