m , 4 j 2018 · restenosis with nanotechnology and redox modulation nicholas buglak, wulin jiang,...
TRANSCRIPT
Monday, 4 June 2018
Auditorium I
09:00Early Career Symposium (ECS)Chairs:Sarah ChappleKing´s College London, UK
Consuelo BorrásUniversidad de Valencia, Spain
Bárbara RochaUniversity of Coimbra, Portugal
Regi
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tion
09:0009:20 Keynote 1
The Decline of Adaptive Homeostasis & AdaptiveProteostasis in AgeingKelvin J. A. DaviesUniversity of Southern California, Los Angeles, USA
09:2009:35 Iodide modulates oxidative protein modication
induced by myeloperoxidaseLuke Gamon, Marta Ignasiak, Simon Dieterich, MaxSauerland, Michael DaviesUniversity of Copenhagen, Denmark
09:3509:50 Mitochondrial hydrogen peroxide levels in
healthy peripheral nerves and peripheralneuropathiesGerben van Hameren, Nicolas TricaudInstitute for Neurosciences Montpellier, France
09:5010:05 Boost of vitamin E metabolism as a novel
treatment strategy for myocardial infarctionMaria Wallert, Melanie Ziegler, Xiaowei Wang, AnaMaluenda, Stefan Lorkowski, Karlheinz PeterBaker Heart and Diabetes Institute, Melbourne, Australia;University of Jena, Germany; Competence Cluster forNutrition and Cardiovascular Health (nutriCARD),Germany; Monash University, Australia
10:0510:20 Deregulation of small intestine permeability by
miRNA-21 in liver diseaseAndré Anastácio Santos, Marta Bento Afonso,Pedro Miguel Rodrigues, Rui Eduardo Castro,Cecília Maria Pereira RodriguesUniversity of Lisbon, Portugal
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10:2010:35 High-fat and high cholesterol diet induces
Alzheimer’s like disease in miceGianni Mancini, Cândida Dias, Cátia Lourenço, RuiM. Barbosa, João Laranjinha, Andreza F. de Bem,Ana LedoUniversidade Federal de Santa Catarina, Florianópolis,Brazil; Center for Neuroscience and Cell Biology, Coimbra,Portugal; University of Coimbra, Portugal
10:3510:50 Improving arterial surgery outcomes: Combating
restenosis with nanotechnology and redoxmodulationNicholas Buglak, Wulin Jiang, Samuel Stupp,Melina Kibbe, Edward Moreira BahnsonUniversity of North Carolina at Chapel Hill andNorthwestern University, USA
10:5011:05 Redox regulation in human endothelial
cells: a critical role for the glycocalyx inmechanotransduction of fluid shear stressParaskevi-Maria Psefteli, Mark Fowler, Giovanni E.Mann, Richard C. SiowKing’s College London, UK; Strategic Science Group,Unilever R&D, Colworth, UK
11:0511:25 Keynote 2
The nitrate-nitrite-NO pathway in health and diseaseJon O. LundbergKarolinska Institutet, Stockholm, Sweden
11:2512:00 Coffee Break
Auditorium I12:0012:05 Symposium YIA 2017
Chairs:Daniela CaporossiForo Italico University of Rome, Italy
Giuseppe ValacchiUniversity of Ferrara, Italy
12:0512:20 Synthesis and separation of peptide-oxidized
phospholipid adducts, a potential lipoxidationmarkerCatarina B. Afonso, Andrew R. Pitt, Corinne M. SpickettAston University, Birmingham, UK
12:2012:35 Scavenger receptor B1 as a new target for
pollution-induced oxidative skin damageXimena Maria Muresan, Giuseppe Belmonte, ClaudiaSticozzi, Franco Cervellati, Florian Gruber, GiuseppeValacchiUniversity of Ferrara, Italy; Medical University of Vienna,Austria; Christian Doppler Laboratory for Biotechnologyof Skin Aging, Vienna, Austria; NC State University, USA
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12:3512:50 Transcription factor NRF2 modulates chaperone
mediated autophagy through the regulation ofLAMP2AMarta Pajares, Ana I. Rojo, Esperanza Arias, AntonioDiaz-Carretero, Ana Maria Cuervo, Antonio CuadradoUniversity of Madrid, Spain; CIBERNED, ISCIII, Madrid,Spain; Albert Einstein College of Medicine, NY, USA
12:5013:05 Molecular mechanisms of HO-1 up-regulation in
neuroblastoma cell response to oxidative stressSabrina Piras, Anna Lisa Furfaro, Rocco Caggiano,Lorenzo Brondolo, Umberto Maria Marinari, MariaAdelaide Pronzato, Raaella Faraonio, Mariapaola NittiUniversity of Genoa, Italy; University of Naples “FedericoII”, Italy
13:0513:20 Novel redox-targets of NADPH oxidase 4
Oliver Löwe, Juliana Heidler, Ilka Wittig, Katrin Schröder,Flavia Rezende, Ralf P. BrandesGoethe University Frankfurt, Germany
13:2014:00 ECS/YIA delegates lunch
Auditorium I 14:0016:00 Workshop Elsevier
Chair:Ana LedoCenter for Neurosciences and Cell Biology, Coimbra, Portugal
How to write a great research paper, and get itaccepted by a good journalAnthony NewmanLife Sciences Department, Elsevier, Amsterdam, The Netherlands
16:0017:30 Welcome address
Auditorium I16:3017:30
Trevor Slater Award LectureChairs:Shinya ToyokuniNagoya University, Japan
Josiane CillardUniversité de Rennes, France
Metabolism and Redox Signaling in Brain AgingEnrique CadenasUniversity of Southern California, Los Angeles, USA
17:3018:00 Catherine Pasquier lecture
Chairs:Michael J. DaviesUniversity of Copenhagen, Denmark
Analysis of oxidised lipids; validation and applicationIrundika DiasAston University, Birmingham, UK
18:0019:30 Welcome Cocktail
Tuesday, 5 June 2018
Auditorium I Auditorium III+IV Pavilion 508:3010:30 Symposium I - The biology
of H2O2 after 200 years of itsdiscovery by ThenardSponsored by:
Chairs:Helmut SiesHeinrich-Heine-UniversityDüsseldorf, Germany
Enrique CadenasUniversity of SouthernCalifornia, Los Angeles, USA
Symposium II - Ferroptosis:A Program or a Free RadicalCatastrophe?Chairs:Marcus ConradHelmholtz Zentrum Muenchen,Germany
Valerian E. KaganUniversity of Pittsburgh, USA
Symposium III - Oxidativestress and signaling byreactive oxygen andnitrogen species in plantsChairs:Gary J. LoakeEdinburgh University, UK
Frank Van BreusegemGhent University – VIB, Gent,Belgium
08:3009:00 H2O2 as a central redox
signaling molecule inphysiological oxidativestressHelmut SiesHeinrich-Heine-University,Düsseldorf, Germany
Ferroptosis: Death by lipidperoxidationBrent StockwellColumbia University, New York,USA
Nitric oxide signalling indeconvolutionGary J. LoakeEdinburgh University, UK
09:0009:30 Genetically encoded
molecular tools for H2O2imaging and manipulationVsevolod V. BelousovShemyakin-OvchinnikovInstitute of Bioorganic Chemistry, Moscow, Russian Federation
Molecular underpinningscontrolling ferroptotic celldeathMarcus ConradHelmholtz Zentrum Munich,Germany
Plant oxidative stresssignaling: towards theproteome and beyondFrank Van BreusegemGhent University – VIB, Gent,Belgium
09:3010:00 Control of AQP8- dependent
H2O2 transport across the plasma membrane: Implications for cell signalingRoberto SitiaIRCCS Ospedale San Raaeleand Università Vita-Salute,Milan, Italy
Oxidation ofphosphatidylethanolaminesas ferroptotic signals:control by lipoxygenasesValerian E. KaganUniversity of Pittsburgh, USA
Reactive oxygen species,nitric oxide and hydrogensulfide in plant cellregulationJohn T. HancockUniversity of the West ofEngland, Bristol, UK
10:0010:30 Role of NOX-generated
reactive oxygen species inhealth and diseaseKarl-Heinz KrauseUniversity of Geneva, Switzerland
Iron and ferroptosis inthe pathogenesis ofAlzheimer´s diseaseJames DuceUniversity of Cambridge, UK
Interaction betweenantioxidants and reactivenitrogen species duringpepper fruit ripeningJosé M. PalmaEstación Experimental delZaidín, Granada, Spain
10:3011:00 Poster Viewing, Coffee Break and Commercial Exhibit
Auditorium I11:0011:30 Leopold Flohe Award Lecture
Chairs:Leopold FloheOtto von Guericke University, Germany
José ViñaUniversity of Valencia, Spain
Pathways of myeloperoxidase-induced cellular damage in atherosclerosisClare HawkinsUniversity of Copenhagen,Denmark
11:30 12:15 SFRRE Annual Lecture
Chairs:Giovanni E. MannKing’s College London, UK
Henry Jay FormanLeonard Davis School of Gerontology, CA, USA
New horizons in hypoxia signaling pathways in health and diseasePeter J RatcliffeUniversity of Oxford and The Francis Crick Institute, London, UK
12:15 13:30
Lunch, Poster Viewing, Commercial Exhibits
Pavilion 5
Women in Science SessionChairs:Lin MantellSt. John’s University College of Pharmacy, NY, USA
Mari Carmen Gómez-CabreraUniversity of Valencia, Spain
Mariapaola NittiUniversità degli Studi di Genova, Genoa, Italy
Auditorium I Auditorium III+IV Pavilion 513:3015:30 Symposium IV - Molecular
Oxygen in Health AndDisease: One Tissue’sHypoxia is Another’sHyperoxiaSponsored by:
Chairs:Giovanni E. MannKing’s College London, UK
Thomas P. KeeleyKing’s College London, UK
Symposium V - BiologicalRoles of Heme-Protein RedoxInteractionsChairs:Roland StockerVictor Chang CardiovascularResearch Institute, Australia
Miguel P. SoaresInstituto Gulbenkian de Ciência,Portugal
Symposium VI - CrosstalkBetween OxidativeStress and Inflammationin CerebrovascularDisease: Mechanisms andTherapeutic InterventionsChairs:Saverio Francesco RettaUniversity of Torino, Italy
Kathy GriendlingEmory University, Georgia, USA
13:3014:00 Redox regulation under
physiological oxygen levelsGiovanni E. MannKing’s College London, UK
Heme regulation of glucosemetabolism in bloodstreaminfectionsMiguel P. SoaresInstituto Gulbenkian de Ciência,Portugal
Inflammation and immunemechanisms of braindamage after strokeChristopher G SobeyUniversity of Oxford and The La Trobe University, Melbourne,VIC, Australia
14:0014:30 Substrate selectivity of
prolyl hydroxylasesMichael A. McDonoughUniversity of Oxford, UK
Singlet molecular oxygenregulates vascular toneand blood pressure ininflammationRoland StockerVictor Chang CardiovascularResearch Institute, Australia
Nox4, Poldip2 andvascular functionKathy GriendlingEmory University, Atlanta, USA
14:3015:00 Oxygen in cancer and
neovascularizationSharon GerechtJohns Hopkins University,Baltimore,USA
Heme degradation in Myco-bacterium tuberculosisMasao Ikeda-SaitoTohoku University, Sendai,Japan
ROS-induced ROS releaseorchestrated by Nox4,Nox2 and mitochondriain VEGF signaling drivingendothelial metabolismand angiogenesisMasuko Ushio-FukaiAugusta University, Augusta,USA
15:0015:30 Oxygen homeostasis
in intestinal health andinflammationEric CampbellQueen’s University Belfast, UK
Evolution of structureand function of humanperoxidasesChristian ObingerUniversity of Natural Resourcesand Life Sciences, Vienna,Austria
Oxidative Stressand inflammation incerebral cavernousmalformation diseasepathogenesis: Toward aunifying mechanistic andtherapeutic landscapeSaverio Francesco RettaUniversity of Torino, Italy
15:3016:00 Coffee Break
Auditorium I Auditorium III+IV Pavilion 516:0017:30 Oral presentation 1 -
Cardiovascular RedoxSignalingChair: Maria MonsalveInstituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Spain
John MaguireOCC, USA
Oral presentation 2 - Thiols-Disulfide Exchange in CellSignalingChair: Fabio VirgiliResearch Centre for Foodand Agriculture, Rome, Italy
Cesar FragaUniversity of Davis, USA
Oral presentation 3 - Redox Signaling in Plants and MammalsChair: Bato KoracUniversity of Belgrade, Serbia
Tilman GruneGerman Institute of Human Nutrition, Potsdam, Germany
16:0016:15 Inflammatory mediators
and atmospheric O2exacerbate antioxidantdefences in endothelialcellsThomas Keeley, Giovanni MannKing’s College London, UK
Specific irreversibletargeting of theselenoprotein thioredoxinreductase 1 in cancertherapyElias S.J. ArnérKarolinska Institutet, Sweden
The human Golgi anti-poptotic protein induces cell invasion by an H2O2- dependent mecha-nismNuno Almeida, Guia Carrara,Ana Fernandes, Maddy Parsons, Geoffrey Smith, Nuno SaraivaCBIOS, Universidade Lusófona, Lisboa, Portugal; University of Cambridge, UK; King’s College London, UK
16:1516:30 Mitochondrial Na+
import controls oxidativephosphorylation andhypoxic redox signallingPablo Hernansanz-Agustín,Elena Ramos, Tamara Villa-Piña,Elisa Navarro, Esther Parada,Laura Moreno, Alicia Izquierdo-Álvarez, Tamara Oliva, J. DanielCabrera-García, Ana Cortés, Daniel Tello, Rebeca Acín-Pérez, Izaskun Buendia, Juan Carlos Rodríguez-Aguilera, Plácido Navas, Ángel Cogolludo, Álvaro Martínez-del-Pozo, Javier Egea, Manuela G. López, Anna Bogdanova, José Antonio Enríquez, Antonio Martínez-RuizI. de Investigaciones SanitariasPrincesa, Madrid, Spain; F. Medicina,Univ. Autónoma de Madrid and I. deInvestigaciones Biomédicas AlbertoSols, Madrid, Spain; F. Medicina,Univ. Autónoma de Madrid, I. deInvestigaciones Sanitarias Princesa,Madrid, Spain; Univ. Complutensede Madrid, Spain; Centro deInvestigación Biomédica en Red deEnfermedades Respiratorias, Spain;Univ. Pablo de Olavide-CSIC, Sevilla,Spain; Centro de InvestigaciónBiomédica en Red de EnfermedadesRaras, Spain; I. de InvestigacionesSanitarias Princesa, Madrid, Spain;Centro Nacional de InvestigacionesCardiovasculares Carlos III, Madrid,Spain; Centro de InvestigaciónBiomédica en Red de Fragilidad yEnvejecimiento Saludable, Spain;Univ. Complutense de Madrid, Spain;Univ. of Zurich, Switzerland; Centrode Investigación Biomédica en Redde Enfermedades Cardiovasculares,Spain
Lipid peroxidation andGPx4: the players of theoxygen paradoxFulvio Ursini, Valentina Bosello-Travain, Giorgio Cozza, MariaLuisa Di Paolo, Giovanni Miotto,Monica Rossetto, AntonellaRoveri, Stefano Toppo, RinaVenerando, Ana-Marija VučkovićMattia Zaccarin, MatildeMaiorinoDepartment of MolecularMedicine, University of Padova,Italy
Redox signaling in plantsJoris MessensVIB-VUB Center for StructuralBiology, VIB, Brussels, Belgium;Brussels Center for Redox Biology, Brussels, Belgium; Vrije Universiteit Brussel, Brussels, Belgium
16:3016:45 Regulation of UCP3
expression and function inresponse to hypoxia andoxidative stress in mousecardiomyocytesPatricia Sánchez-Pérez, EliaLópez-Bernardo, AndreaAnedda, Susana CadenasCentro de Biología Molecular“Severo Ochoa” , Madrid, Spain;Instituto de InvestigaciónSanitaria Princesa, Madrid, Spain
Thioredoxin-relatedprotein of 14 kDa maydirectly reduce proteincysteinylation motifsPablo Martí-Andrés, Isabela Finamor, Belén Espinosa, Salvador Pérez, Sergio Rius-Pérez, Raquel Taléns-Visconti, Rafel León, Antonio Martínez-Ruiz, Elias S.J. Arnér, Juan SastreUniversity of Valencia, Burjassot,Spain; Federal University of SantaMaria, Rio Grande do Sul, Brazil;Karolinska Institutet, Stockholm,Sweden; Instituto Teólfilo Hernando, Instituto de Investigación Sanitaria Princesa, Madrid, Spain
Redox responses todenervation in skeletalmuscleMattia Scalabrin, NataliePollock, Anne McArdle,Malcolm J. Jackson,Aphrodite VasilakiUniversity of Liverpool, U.K.
16:45 17:00 Human mercaptalbumin
and nuclear factor kappaB in subjects with mildlyimpaired renal, vascularand metabolic healthcompared to “super-healthy”subjects: the BIOCLAIMS Integration studyBrigitte M. Winklhofer-Roob,Gernot Faustmann, Karl Öttl,Hildegard Hafner-Giessauf,Johanna Grabher, PetraKieslinger, Matteo C. Sattler,Barbara Obermayer-Pietsch,Beate Tiran, Johannes M. RoobUniversity of Graz, Austria
Bicarbonate is requiredfor hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxinMarkus Dagnell, Qing Cheng, Paul E. Pace, Mark B. Hampton, Christine C. Winterbourn, Elias S.J. ArnérKarolinska Institutet,Stockholm, Sweden; Universityof Otago, Christchurch, NewZealand
Peroxidase, holdaseand signaling functionsof Trypanosomacruzi mitochondrialperoxirredoxinGabriela Specker, DamiánEstrada, Carolina Prolo, MaríaNoel Alvarez, Rafael Radi, Lucía PiacenzaUniversidad de la Repúblicaand Center for Free RadicalBiology and Medicine (CEIN-BIO), Montevideo-Uruguay
17:00 17:15 Mechanosensitive miR-320a
and miR-21-3p regulate Bach1 expression in endothelial cellsPhoebe Kitscha, Giovanni E Mann, Richard C SiowFaculty of Life Sciences andMedicine, King’s College LondonUK
Silencing Bach1 mRNA alters the age-related changes in Nrf2-dependent gene regulation in primary human bronchial epithelial cellsHenry Jay Forman, Jiuqi Zhang, Hongqiao ZhangLeonard Davis School of Gerontology, University of Southern California Los Angeles, USA
Oxidation of disulfidebonds: a novel pathway toprotein glutathionylationLuke Carroll, ShuwenJiang, Kasper Engholm-Keller, Adelina Rogowska-Wrzesinska, Michael DaviesUniversity of Copenhagen,Denmark; University ofSouthern, Denmark
17:15 17:30 Kinetic and stoichiometric
constraints determine the pathway of H2O2 consumption by red blood cellsFlorencia Orrico, Matías N. Möller, Adriana Cassina, Ana Denicola, Leonor ThomsonUniversidad de la República, Montevideo, Uruguay
Targeting mitochondria by TrxR2 inhibitionMaria Pia Rigobello, Valeria Scalcon, Federica Tonolo, Alessandra Folda, Anne Vessières, Michèle Salmain, Alberto BindoliUniversità di Padova, Italy; Sorbonne Université, Paris, France; Dipartimento di Scienze Biomediche, Padova, Italy
Glutathione S-transferase P influences the Nrf2-de-pendent control of cellular glutathione metabolismBartolini Desirée, Giustarini Daniela, Pietrella Donatel-la, Marinelli Rita, Torquato Pierangelo, Rossi Ranieri, Galli FrancescoUniversity of Perugia, Italy; University of Siena, Italy
17:30 19:30 Poster Viewing, Refreshments and Commercial Exhibits
Wednesday, 6 June 2018
Auditorium I Auditorium III+IV Pavilion 508:30 10:30 Symposium VII - Nitric
Oxide BiochemistryChair: Thomas MichelHarvard Medical School, Boston,USA
Santiago LamasCentro de Biología Molecular“Severo Ochoa”, Spain
Symposium VIII - ReactiveOxygen Species andMusculoskeletal AgeingChair: Malcolm J. JacksonInstitute Ageing & ChronicDisease, University of Liverpool,UK
Anne McArdleInstitute Ageing & ChronicDisease, University of Liverpool,UK
Symposium IX - A Systems-Oriented Perspective onKey Processes in RedoxStress and RegulationChair: Fernando AntunesUniversidade de Lisboa, Portugal
Armindo SalvadorUniversidade de Coimbra,Portugal
08:30 09:00 Soluble guanylate cyclase
activation by nitric oxideMichael A. MarlettaUniversity of California Berkeley,USA
NADPH oxidase Nox4 inosteoporosisKatrin SchröderGoethe-University Frankfurt,Germany
Superoxide radical-nitricoxide interplay and thefate of peroxynitrite inbiological systemsRafael RadiUniversidad de la República,Montevideo, Uruguay
09:00 09:30 Nitroso-oxidative stress
and cardiovasculardiseaseJoseph LoscalzoHarvard Medical School, Boston,USA
Aberrant redox signalingin age-related muscledeclineAnne McArdleUniversity of Liverpool, UK
Quantitative analysisof cytosolic andmitochondrial H2O2metabolism and toxicityin human epithelial cellsHadley D. SikesMassachusetts Institute ofTechnology, Cambridge, USA
09:30 10:00 Nitric oxide synthases,
oxidant stress and cardiacremodelingJean-Luc BalligandUniversité Catholique deLouvain, Brussels, Belgium
Modelling of the role of re-dox-related mechanisms in decline of musculoskeletal systemAlvaro Martinez GuimeraUniversity of Newcastle, UK
Identification andquantification of proteindamage induced byinflammatory oxidantsMichael J. DaviesUniversity of Copenhagen,Denmark
10:00 10:30 Regulation of nitric oxide
synthases by intracellular oxidantsThomas MichelHarvard Medical School, Boston, USA
Ultra-long-distancerunning and the liver. Interna-tional journal of sports medi-cineZsolt RadakUniversity of Physical Education,Budapest, Hungary
Environmental stressors and cardiovascular risk: Im-pact of environmental noise exposure on vascular oxida-tive stress and damage Andreas DaiberUniversity Medical Center at the Johannes Gutenberg University Mainz, Germany
10:30 11:00 Poster Viewing, Coffee Break and Commercial Exhibits
Auditorium I11:00 11:40 SFRRE Basic Science Award Lecture
Sponsored by: Chairs:Juan SastreUniversity of Valencia, Spain
Brigitte Winklhofer-RoobUniversity of Graz, Austria
Exploring mitochondrial free radical production in health and diseaseMike MurphyMRC Mitochondrial Biology Unit, University of Cambridge, UK
11:40 12:20 SFRRE Clinical Science Award Lecture
Sponsored by:
Chairs:Aphrodite VasilakiUniversity of Liverpool, UK
Antonio Martínez RuizHospital de la Princesa, Madrid, Spain
Taking oxidative stress from the bench to the bedside, exemplified by RNA oxidationHenrik Enghusen PoulsenUniversity of Copenhagen, Denmark
12:20 13:30 Lunch, Poster Viewing, Commercial Exhibits
Auditorium I Auditorium III+IV Pavilion 513:30 15:30 Symposium X - Caloric
Restriction and Mimetics asInterventions in AgingSponsored by:
Chairs:José ViñaUniversity of Valencia, Spain
Mari Carmen Gómez-CabreraUniversity of Valencia, Spain
Symposium XI - SPBSymposium – MolecularMechanisms of DiseaseSponsored by:
Chairs:João LaranjinhaUniversity of Coimbra, Portugal
Leonor CancelaUniversity of Algarve, Portugal
Symposium XII - Advancesin MitochondrialPhysiology and MedicineSponsored by:
Chairs:Danica ChenUniversity of California Berkeley,USA
Lester PackerUniversity of Southern California,Los Angeles, USA
13:30 14:00 A novel nutrient blend
mimics calorie restrictiontranscriptomics inmultiple tissues of miceand increases vitality andlifespan in C. elegansAngela MastaloudisNu Skin Enterprises, Provo, UT,USA
Brain redox bioenergeticsare determined byOXPHOS organization inneurons and astrocytesJuan Pedro BolañosUniversity of Salamanca, Spain
Mitochondria andhematopoietic stem cellMaegan CapitanoIndiana University School ofMedicine, Indianapolis, USA
14:00 14:30 Malnutrition vs calorie
restriction: The effectson maternal nutrientreduction in cardiac fetalmitochondrial functionPaulo J. OliveiraCNC, University of Coimbra,Portugal
Molecular mechanismsregulating gliahomeostasisJoão B. RelvasUniversidade do Porto, Portugal
The mitochondrialmetabolic checkpoint,stem cell aging andrejuvenationDanica ChenUniversity of CaliforniaBerkeley, USA
14:30 15:00 Exercise as a calorie
restriction mimetic.Implications for thetreatment of ageassociated frailtyMari Carmen Gómez-CabreraUniversity of Valencia, CIBERFES,INCLIVA, Valencia, Spain
SIRT3, a modifier ofmitochondrial function inHuntington’s diseaseA. Cristina RegoUniversity of Coimbra, Portugal
Keeping mitochondriain shape: a matter of lifeand deathLuca ScorranoUniversity of Padua, Italy
15:00 15:30 The SPRINTT project:
tackling physical frailtyand sarcopenia to preventdisability in the elderlyEmanuele MarzettiCatholic University of the SacredHeart, Rome, Italy
Molecules and mechanisms inmaladaptative stressNuno SousaUniversidade do Minho, Braga,Portugal
Mitochondria in kidneydisease and recoveryRick G. SchnellmannUniversity of Arizona College ofMedicine, Tucson, USA
15:30 16:00 Coffee break
Auditorium I Auditorium III+IV Pavilion 516:00 17:30 Oral presentation 4 - Brain
Redox Biology, Metabolism,and CognitionChairs: Catarina OliveiraCenter for Neuroscience and CellBiology, University of Coimbra,Portugal
Rui BarbosaUniversity of Coimbra, Portugal
Oral presentation 5 - RedoxSignaling in Health andDiseaseChairs: Paul WittingUniversity of Sydney, Australia
Yuji NaitoKyoto Prefectural University of Medicine, Japan
Oral presentation 6 - RedoxStress in CancerChairs: Regina Brigelius-FlohéUniversity of Potsdam, Germany
Lin MantellSt. John’s University College of Pharmacy, NY, USA
16:00 16:15 BDNF differentially
activates Nrf2 in astrocytesand neuronsTetsuro Ishii, Eiji Warabi,Giovanni E MannUniversity of Tsukuba, Ibaraki,Japan; Faculty of Life Sciences andMedicine, King’s College London,U.K.
Nitric oxide mediated neurovascular coupling is maintained under hypoxia through asorbate-dependent nitrite reduction to NO: An in vivo study in the hippocampusNuno R. Ferreira, Cátia F.Lourenço, Rui M. Barbosa, JoãoLaranjinhaUniversity of Coimbra, Portugal
The role of necroptosisin non-alcoholic fattyliver disease-relatedcarcinogenesisMarta B. Afonso, Pedro M.Rodrigues, André L. Simão,André A. Santos, Maria M.Gaspar, Rui E. Castro, Cecília M.P. RodriguesUniversidade de Lisboa, Portugal
16:15 16:30 The dys-regulation of
anti-oxidant defense viaan impairment of Nrf2response in the pathologyof Friedreich’s ataxiaShannon Chiang, Amy Anzovino,Bronwyn E. Brown, Clare L.Hawkins, Des R. Richardson,Michael L.-H. HuangUniversity of Sydney, Australia;Heart Research Institute,Newtown, Australia; University ofCopenhagen, Denmark
NOX2 is a major ROSsource in exercising muscleregulating glucose uptakeCarlos Henríquez-Olguin, JonasR. Knudsen, Steen H. Raun,Zhencheng Li, Lykke Sylow, ErikA. Richter, Enrique Jaimovich,Thomas E. JensenUniversity of Copenhagen,Denmark
Cellular metalsequestration andredox stress bythiosemicarbazonesinduces endoplasmicreticulum stress in tumorsto suppress cancerprogressionAngelica Merlot, Nurul Shafie,Elizabeth Lim, Amanda Chen,Sumit Sahni, Yu Yu, DesRichardsonUniversity of Sydney, NSW,Australia
16:30 16:45 Intranasal rapamycin
protects against cognitivedecline in a mouse model ofDown syndromeFabio Di Domenico, AntonellaTramutola, Chiara Lanzillotta,Ilaria Zuliani, Andrea Arena,Eugenio Barone, Marzia PerluigiSapienza University of Rome, Italy
ROS regulatedevelopmental andpathological denervation invivoEva Sidlauskaite, Ian L. Megson,Phil D. Whiteld, Ines Batinic-Haberle, Michael P. Murphy,James N. Cobley, Peter R. MoultAbertay University, Dundee,UK; University of Highlandsand Islands, Inverness, UK; DukeUniversity, Durham, USA;University of Cambridge, UK
Myoglobin inducesmitochondrial fusionto inhibit cancer cellproliferation and tumorgrowthAndrea Braganza, KellyQuesnelle, Lisa Arnotti,Shivendra Singh, Sruti ShivaUniversity of Pittsburgh School ofMedicine, USA
16:45 17:00 Amyloid-β peptide
irreversibly blocks mitochondrial biogenesis and dynamics ofself-renewing neural stem cells compromising neurogenesisMaria Filipe Ribeiro, TâniaGenebra, Cecília Rodrigues,Susana SoláUniversidade de Lisboa, Portugal
Alpha-synuclein inducesferroptosis throughgeneration of lipidperoxidation and calciumderegulationPlamena R. Angelova, Minee-Liane Choi, Mathew H. Horrocks, David Klenerman, Sonia Gandhi, Andrey Y. AbramovUCL Institute of Neurology, London, UK
A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipidsMarie-Sophie Narzt, Ionela-Mariana Nagelreiter, Olga Oskolkova, Valery Bochkov, Julie Latreille, Maria Fedorova, Zhixu Ni, Fernando J. Sialana, Gert Lubec, Manuel Filzwieser, Maria Laggner, Martin Bilban, Michael Mildner, Erwin Tschachler, Johannes Grillari, Florian GruberMedical University of Vienna; BOKU University; University of Graz; University of Vienna; Paracelsus University
17:00 17:15 SIRT3 overexpression
in neurons enablesβ-oxidation and preventspalmitate-induced insulinresistanceEugenia Alfine, Kristina Wardelmann, André KleinriddersGerman Institute of Human Nutrition, Potsdam-Rehbrücke, Germany; German Center for Diabetes Research, Neuherberg, Germany
NADPH oxidase is a target for (-)-epicatechin in the prevention of fatty acid-induced insulin resistanceEleonora Cremonini, Patricia I OteizaUniversity of California Davis, USA
Nitroxide radical-containing nanoparticles impairs the tumorigenic potential of triple negative breast cancerBabita Shashni, Yukio Nagasaki University of Tsukuba, Ibaraki, Japan
17:15 17:30 Age-dependent changes of
neurovascular coupling and brain metabolism in Fischer 344 ratsCátia F. Lourenço, Ana Ledo, Miguel Caetano, Rui M. Barbosa, João LaranjinhaUniversity of Coimbra, Portugal
oxSWATH: an integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screeningSandra I. Anjo, Matilde N. Melo, Liliana R. Loureiro, Lúcia Sabala, Pedro Castanheira, Mário Grãos, Bruno ManadasUniversity of Coimbra, Portugal; University of Aveiro, Portugal; Biotechnology Transfer Association, Cantanhede, Portugal
TGF-β1-induced epithelial-to-mesenchymal transition depends on mitochondrial dysfunction and biogenesis impairment in lung cancer cellsJiaxin Zhang, Wei Zhang, QingbiaoZhou, Deqin Kong, Hai Chun-xu, Rui Liu Medical University of the Air Force, Changchun, P.R. China
17:30 19:30 Poster Viewing, Refreshments and Commercial Exhibits
20:30Gala Dinner (venue: Estufa Fria)
Thursday, 7 June 2018
Auditorium I Auditorium III+IV Pavilion 508:30 10:30 Symposium XIII - Redox
Biology Based Preventionand Treatment of Cancerin the Era of PrecisionMedicineChairs:Shinya ToyokuniNagoya University GraduateSchool of Medicine, Japan
Young-Joon SurhSeoul National University,South Korea
Symposium XIV - Autophagy in Pathophysiology (GEIRLI Symposium)
Chairs:Jordi MuntanéInstitute of Biomedicine ofSeville, Spain
Victor Manuel VictorUniversidad de Valencia, Spain
Symposium XV - Regulation of Hydrogen Sulfide Signalling in MammalsChairs:Elias ArnérKarolinska Institutet, Stockholm,Sweden
Péter NagyNational Institute of Oncology,Budapest, Hungary
08:30 09:00 Bright and dark sides of
KEAP1-NRF2 system incarcinogenesisHozumi MotohashiTohoku University, Sendai,Japan
Autophagy and its link tothe endoplasmic reticulumVeit GoderDepartment of Genetics,University of Seville, Spain
Metabolic reprogramming by hydrogen sulfideRuma BanerjeeUniversity of Michigan, Ann Arbor, USA
09:00 09:30 A radical drug
mechanism to inhibittumor growth,metastasis, andresistance: targetinglysosomal P-glycoproteinD. R. RichardsonUniversity of Sydney, NSW,Australia
Free radicals at thecrossroads of autophagyand immunityJennifer MartinezNIEHS, Research Triangle Park,NC, USA
Cysteinyl-tRNA synthetase(CARS) controls endogenous hydropersulfide production and mitochondrial respirationTakaaki AkaikeTohoku University Graduate School of Medicine, Sendai, Japan
09:30 10:00 Differential roles for
the redox sensitivetranscription factor Nrf2in carcinogenesisYoung-Joon SurhSeoul National University,South Korea
Autophagy deficient miceas a model for studyingstress-induced autophagyin vivoGuillermo MariñoUniversity of Oviedo/Principalityof Asturias Sanitary ResearchInstitute (ISPA), Spain
Dynamic redox cyclingof hydrogen sulfide andpolysulfide species couldrepresent an importantregulatory element in sulfurbiologyPéter NagyNational Institute of Oncology,Budapest, Hungary
10:00 10:30 Ferroptosis in
carcinogenesis and tumor biologyShinya ToyokuniNagoya University Graduate School of Medicine, Japan
The role of autophagy andcancerGuillermo VelascoComplutense University andInstituto de InvestigacionesSanitarias San Carlos, Madrid,Spain
TrxR1- and Gsr-double-null mouse livers reveal un-expected mechanisms of redox homeostasis, oxida-tive damage defense, and long-term survivalEdward E. Schmidt Montana State University, USA
Auditorium I10:30 11:30 Forum discussion/debate: Science and Society
Chairs:João LaranjinhaUniversity of Coimbra, Portugal
Enrique CadenasUniversity of Southern California, Los Angeles, USA
Knowledge and dialogue to deal with uncertaintyAlexandre QuintanilhaUniversity of Porto, Portugal
11:30 12:00 Coffee Break
Auditorium I Auditorium III+IV Pavilion 512:00 14:00 Symposium XVI - Defence
and Adaptation – The Critical Role of Reactive Oxygen SpeciesSponsored by:
Chairs:Helen GriffithsUniversity of Surrey, UK
Corinne SpickettAston University, UK
Symposium XVII - SPB Symposium – Molecular structure and FunctionSponsored by:
Chairs:Graça SoveralUniversity of Lisbon, Portugal
Cláudio SoaresNova University of Lisbon, Portugal
Oral presentation 7 - Nitrite,Peroxynitrite, and OxidizedLipidsChairs:Richard SiowKing’s College London, UK
Bertrand FriguetPierre and Marie Curie University, Paris 6, France
12:00 12:30 NOX2-derived ROS in
myeloid cell differentiation:Implications in cancer
Anna MartnerUniversity of Gothenburg,Sweden
CO2 toxicity: Role forredox reactions?
Ohara AugustoUniversidade de São Paulo, Brazil
12:00 - 12:15
Effect of short-chainaldehydes on the enzymaticactivity of pyruvate kinaseBebiana C. Sousa, Jed Ashman,Corinne M. Spickett, Andrew R.PittAston University, Aston Triangle,Birmingham, UK
12:15 - 12:30
Analytical strategies for theidentification of oxidizedlipids from adipose tissueMike Lange, Zhixu Ni,GeorgiaAngelidou, Maria FedorovaUniversität Leipzig, Germany
12:30 13:00 NOX2 NADPH oxidase
controls responses to infection and sterile inflammation
Mary C. DinauerWashington University in StLouis School of Medicine, USA
Structural insights on aldehyde oxidase and xanthine oxidoreductaseand their roles in xenobiotic metabolism
Maria João RomãoNOVA University of Lisbon,Portugal
12:30 - 12:45
Generation of biliverdinreductase-a gene knockoutmice to study the in vivoactivities of bilirubinWeiyu Chen, Ghassan Maghzal,Anita Ayer, Cacang Suarna,Louise Dunn, Roland StockerVictor Chang Cardiac ResearchInstitute, Sydney, Australia;University of New South Wales,Sydney
12:45 - 13:00
Dietary nitrate modulatesgut microbiota profile andprevents the activationof mucosal inflammatorypathways induced by broad-spectrum antibioticsBárbara S. Rocha, AnabelaPereira, Gabriela J. Da Silva, João LaranjinhaUniversity of Coimbra, Portugal
13:00 13:30 Reactive oxygen species
ameliorate the clinicalcourse of murine lupus
Markus HoffmannFriedrich-Alexander- University Erlangen- Nuremberg, UK Erlangen
The diversity of linksbetween the functionaland structural features ofcarboxylate transportersin prokaryotic andeukaryotic cells:Implications in healthand biotechnology
Margarida CasalUniversity of Minho, Braga,Portugal
13:00 - 13:15
Role for neutrophil-derivedmyeloperoxidase in promoting acute colitis; inhibition of disease progression with 4-Methoxy TEMPOBelal Chami, Abigail Vallejo,Stephen KumJew, Nina Dicker-hof, Anthony J. Kettle, Joanne M. Dennis, Paul WittingThe University of Sydney, Austra-lia; University of Otago Christ-church, New Zealand
13:15 - 13:30
A1M-035, an improved human recombinant alpha-1-microglobulin, has therapeutic effects in rhabdomyolysis-induced acute kidney injuryBo Åkerström, Lena Rosenlöf,Anneli Hägerwall, SigurbjörgRutardottir, Jonas Ahlstedt, Maria E Johansson, Lena Erlandsson, Maria Allhorn, Magnus GramLund University, Sweden
13:30 14:00 Oxidative Stress,
‘NObonomics’, sulfur chemistry and the ‘Reactive Species Interactome’ – Lessons from a journey in adaptation to stress
Martin FeelischFaculty of Medicine, University of Southampton, UK
Hidden functions in the capsid protein of Dengue virus: biological relevance and drug development opportunities
Miguel CastanhoUniversity of Lisbon, Portugal
13:30 - 13:45
Declining renal functionand thresholds of estimatedglomerular filtration rate:impact on biomarkersof oxidative stress in theBIOCLAIMS cohortJohannes M. Roob, Gernot Faustmann, Hildegard Hafner-Giessauf, Karl Öttl, WillibaldWonisch , Matteo C. Sattler,Johanna Grabher, Petra Kieslinger, Hans-Jürgen Gruber, Beate Tiran, Brigitte M. Winklhofer-RoobMedical University of Graz, Austria; Karl-Franzens University of Graz, Austria
13:45 - 14:00
Insights into the mechanisms of peroxynitrite-mediated inactivation of human glutamine synthetaseSilvina Bartesaghi, NicolásCampolo, Mauricio Mastrogiovanni, Federico Issoglio, Ari Zeida, Christiane Ott, Tilman Grune, Darío Estrín, Rafael RadiUniversidad de la República,Uruguay; Universidad de BuenosAires, Argentina; German Institute of Human Nutrition, Germany
14:00 14:30 Closing Ceremony