lisa mcqueen - pearl or fecalith?
TRANSCRIPT
Pearl? or Fecalith?Myths and legends in paediatric
emergency and critical careLisa McQueen
@McQueenLisa
“The greater the ignorance, the greater the
dogmatism”-Sir William Osler
Lidocaine with epinephrine is contraindicated in a digital block
Pearl? or Fecalith?
2 RCTs, 103 patientsno complications9 hand surgeons
3,110 digital blocksNo infarction
No phentolamine rescue24 Doppler studies of arterial flow
All fully reversed120 years of medical literature21 cases of digital necrosis
None occur after commercial introduction of lidocaine with epi
Muck AE et al. Six years of epinephrine digital injections: absence of significant local or systemic effects. Annals EM 2010;270-274.
365 accidental injections
4 with ischemia
2 resolved within 2 hours
All resolved uneventfully
Lidocaine with epinephrine is contraindicated in a digital block
Fecalith
Drop atropine from your pediatric RSI strategy
Pearl? or Fecalith?
Infants have exaggerated parasympathetic tone
Laryngoscopy can make them bradycardic
Succinylcholine can make them bradycardic
Hypoxia makes them bradycardic
The treatment for hypoxia is not
atropine
Drop atropine from your pediatric RSI strategy
PEARL
Avoid fluoroquinolone antibiotics in children
Pearl? or Fecalith?
The Beagle Study• Beagle puppies given difloxacin or
placebo• Articular cartilage examined • Within 2 days, vesicles on articular
surface• Over time, dissolution of matrix and
necrosis of chondrocytes
Burkhardt et al. Histologic and biochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathology 1990;27:162-70.
Beagles are not Children• 1795 children who received 2030
treatment courses of ciprofloxacin• Arthralgia in 31 (1.5%)• 60% of these in children with
cystic fibrosis• Arthralgia resolved after
treatment course completed
Hampel et al. Ciprofloxacin in pediatrics: worldwide clinical experience based on compassionate use--safety report. Pediatric Infectious Disease Journal 1997;16:127-9.
Avoid fluoroquinolone antibiotics in children
Fecalith
Avoid aspirin in children to prevent Reye’s syndrome
Pearl? or Fecalith?
Belay ED et al. Reye's sydnrome in the United States from 1981 through 1997. NEJM 1999;340:1377-82.
Did Reye’s syndrome really exist?
Was Reye’s syndrome really from aspirin?
Orlowski JP et al. A catch in the Reye. Pediatrics 1987;80:638-42.
26 cases of Reye’s re-examined1 with aspirin
exposureNo cases after 1983
70% ultimately with
inborn error of metabolism
World-wide decline in influenza B severity
Diagnosis of MC FAOD
Avoid aspirin in children to prevent Reye’s syndrome
Fecalith
No need to use lidocaine for an infant lumbar puncture
Pearl? or Fecalith?
Larry Mellick. Increasing success with infant spinal taps. Emergency Medicine News. April 2013. http://journals.lww.com/em-news/blog/M2E/pages/post.aspx?PostID=11
Children are not little adults
Children are little humans