lipid metabolism-3 phosphoglycerol handouts
TRANSCRIPT
![Page 1: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/1.jpg)
Phosphoacylglycerolalso known as
Glycerophospholipids or Phosphoglycerides
Faisal Khatib MD; PhD
Faculty of Medicine, University of Jordan
G
L
Y
C
E
R
O
L
FATTY ACID
FATTY ACID
PHOSPHOACYLGLYCEROL
PHOSPHATE
ALCOHOL
![Page 2: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/2.jpg)
O║
O CH2O-C-R1║ I
R2C-OCHICH2O- -
Phosphatidic Acid
Can Form Ester with Alchol:
- Serine - Inositol
- Ethanolamine - Glycerol
- Choline
Phosphatidyl -
P
HO-CH2 CH3
Ethanol
HO-CH2CH2-NH3+
Ethanolamine
HO-CH2 CH2 –N(CH3)3+
Choline
HO-CH2 CH-NH3+
ICOO-
Serine
![Page 3: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/3.jpg)
O║
O CH2O-C-R1║ I
R2C-OCH +I - CH3CH2O- - O-CH2 CH2 –NCH3
CH3
Phosphatidyl Choline (Lecithin)
P
![Page 4: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/4.jpg)
![Page 5: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/5.jpg)
![Page 6: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/6.jpg)
Cardiolipin: Two molecules of Phosphatidic Acid Connected through Glycerol
![Page 7: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/7.jpg)
G
L
Y
C
E
R
O
L
FATTY ACID
FATTY ACID
Degradation of Phospholipids:Phospholipase A1Phospholipase A2Phospholipase C
Phospholipase D
PHOSPHATE
ALCOHOL
![Page 8: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/8.jpg)
![Page 9: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/9.jpg)
Biosynthesis of Triacylglycerol & Phosphoacylglycerol
G
L
Y
C
E
R
O
L
FATTY ACID
FATTY ACID
FATTY ACID
TRIACYLGLYCEROL
G
L
Y
C
E
R
O
L
FATTY ACID
FATTY ACID
PHOSPHOACYLGLYCEROL
PHOSPHATE
ALCOHOL
![Page 10: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/10.jpg)
Phosphotadic Acid is Common Intermediate
G
L
Y
C
E
R
O
L
FATTY AC ID
FATTY AC ID
PHOSPHOACYLGLYCEROL
PHOSPHATE
G
L
Y
C
E
R
O
L
FATTY ACID
FATTY ACID
PHOSPHATE
ALCOHOL
Biosynthesis of glycerophospholipids
Alcohol1 Phosphate Alcohol2
Transfer ~(Phosphate-Alcohol1) to Alcohol2 or
Transfer ~(Phosphate-Alcohol2) to Alcohol1
![Page 11: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/11.jpg)
Synthesis of Phosphatidyl Inositol
Transfer or Phosphatidic acid to Inositol
CDP-diacylglycerol + Inositol
CMP Phosphatidyl Inositol
Synthesis of Phosphatidyl Choline
Transfer or Phosphocholine (Ethanolamine) to Diacylglycerol
CDP-Choline Diacylglycerol
CMP Phosphatidyl Choline
![Page 12: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/12.jpg)
Formation of Activated Carrier
Alcohol- P P P P
Ribose-Cytosine
Alcohol- P P
Ribose-Cytosine
P P
CDP-Alcohol Pyrophosphate
~~
~
~
![Page 13: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/13.jpg)
Alteration of Polar Head Group• Exchange of the Polar Head Group
Phosphatidyl Ethanolamine Serine
• Phosphatidyl Serine Ethanolamine
Alteration of Polar Head Group• Decarboxylation of Phosphatidyl Serine
Phosphatidyl Serine
CO2
Phosphatidyl Ethanolamine
![Page 14: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/14.jpg)
Alteration of Polar Head Group• Methylation of Phosphatidyl EthanolamineS- Adenosyl Methionine (SAM); Methyl donor
Phosphatidyl Ethanolamine
Phosphatidyl Choline
CH3-S-CH2CH2-CH-COO-
I IAdenosine NH3+
S- Adenosyl Homocysteine
![Page 15: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/15.jpg)
Remodeling Phospholipids: Changing the Fatty Acid
Ether Glycerophospholipids
![Page 16: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/16.jpg)
Platelet-activating Factor
![Page 17: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/17.jpg)
Surfactant Action of Phospholipids
![Page 18: Lipid Metabolism-3 Phosphoglycerol Handouts](https://reader034.vdocuments.us/reader034/viewer/2022042505/542279417bef0a41108b46fd/html5/thumbnails/18.jpg)