Supplementary Table I. Correlations (R2) between metformin with creatinine, lactate and pH for each patient with MALA.

R2

Patient Metformin vs creatinine Metformin vs lactate Metformin vs pH1 0.928*** 0.733 0.897*

2 0.929*** 0.354 0.577*

3 ND ND ND4 0.829 ND ND5 0.931** ND 0.904*

6 0.976*** 0.879* 0.924**

7 ND ND ND8 0.894*** ND 0.981***

9 0.339 ND ND10 0.666** 0.836** 0.910***

11 0.891*** 0.659** 0.18512 0.534** 0.655 0.640*

13 0.032 ND ND14 ND 0.031 0.35515 ND ND ND

Bruijstens et al. (2008)1 0.857*** 0.583 0.961**

2 ND ND ND3 ND ND ND

Level of significance: *** P<0.001; ** P <0.01; *P <0.05.ND = not done, less than 5 paired samples.

Supplementary Figure 1. Concentration time-profiles for the plasma concentrations of

metformin, creatinine and lactate and arterial pH in each patient. All patients received

continuous renal replacement therapy (CRRT) but the duration of CRRT was only

known in some patients (shaded areas).