lecture 4: fmos (continued) & arrow pushing (the … 4: fmos (continued) & arrow pushing...
TRANSCRIPT
Lecture 4: FMOs (continued) & Arrow Pushing (the beginning) Announcements:
Problem Set 1 comments:•Average: 67% (too low for a review of undergrad organic!)◦Please review your problem set and learn/remember any concepts you are missing◦Answer Key posted online◦
Problem Set 2 due now•NSF GRFP panel tomorrow, 1pm, Smith 140•Today's Organic Journal Club: Dr. Shane Plunkett (postdoc in my lab): PhD summary•Monday: Biochem Colloquium, 4pm, 101 BRL•
Prof. Brian McNaughton, Colorado State "Strategies & Tactics for Biologics Dicovery"Today:
FMOs, continued from last time•Heteroatoms◦Substituent effects◦
12-Step Program for Arrow Pushers•3 Universal Effects that Govern Reactivity & Structure•Arrow-pushing topic: Polar Reactions under Basic Conditions•
Alkyl Electrophiles: Substitution & Elimination◦Addition to Electrophilic π-Bonds: Carbonyls & Conjugate Additions◦
Hard-Soft Acid-Base Theory (HSAB)‣Substitution at sp2 carbons: Carbonyls & Aryl◦
