lecture 15. maintaining blood glc levels glucose is the energy source for many tissues need to keep...
TRANSCRIPT
Lecture 15
Maintaining blood Glc levels
Glucose is the energy source for many tissuesNeed to keep blood glucose level constantNot taking in Glc Blood glucose fallsHow to put Glc into blood?
Carbon sources for Gluconeogeneis: Cori cycle
Carbon sources for Gluconeogeneis
Gluconeogenesis
Gluconeogenesis
Reverse of glycolysis
What step/s have to be different?
Cellular compartments
Where does Glycolysis occur?
Where does TCA occur?
Compartmentalization
http://www.sabiosciences.com/pathwaymagazine/minireview/mitchondrial_energy_metabolism.php
1: How to make PEP?
Cannot directly convert Pyruvate to PEPSo, make Oxaloacetate
1: How to make PEP?
Metabolite compartmentalization must be overcome
1: How to make PEP?
2: If you don’t like it!
2: If you don’t like it!
Remember Fru 2,6-bis-PO4?
3. If you really don’t like it!
Reversing Glycolysis
Reversing Glycolysis
Avoiding “futile” cycles
Signaling cascade recap
LIVER
Example 2: Phosphofructokinase 2
Pancreas
Low Glc
?? Fru 2,6 bis-PO4
Adenylate cyclase↑? PKA?
? PFK1; ? FBPase1? GLYCOLYSIS? GLUCONEOGENESIS
Coordinating metabolism: Recap
Decreased Blood sugarMake hormone: ___________________
Effect on liver: ___________________
Effect on muscle: ___________________
Effect on adipose tissue: ___________________
Increase Blood sugarMake hormone: ___________________
Effect on liver: ___________________
Effect on muscle: ___________________
Effect on adipose tissue: ___________________