lecture 09 – second messengers iii – cadpribose & inositol lipid signaling biol 5190/6190...

Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling

BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy

Last modified -13F

CSB Fig 02:01 Cell signalling pathways

Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

Transducers Second Messengers II

1. Cyclic ADPribose• ADP Ribosyl cyclase

2. Inositol phosphate & other lipid signaling• PLC – PIP2, DAG• PI3K – PIP3• PLD – PA


CSB Fig 2:22 cADPR metabolism


CSB Fig 2:26 NAADP structure


CSB Fig 2:23 cADPR/NAADP function

Transducers Second Messengers II

1. Calcium signaling • 1. Cyclic ADPribose

• 2. Inositol phosphate &

other lipid signaling• PLC – PIP2, DAG• PI3K – PIP3• PLD – PA


CSB Fig 2:30 Phosphoinositide signalling systems


CSB Fig 2:27 Phosphoinositide metabolism


CSB Fig 2:28 PtdIns structure


CSB Fig 2:29 PI 3-K family


CSB Fig 2:31 Inositol phosphate metabolism


CSB Fig 2:32 InsP3 and DAG formation


CSB Fig 2:33 InsP3 and DAG formation


CSB Fig 2:34 InsP3/Ca2+ signalling functions


CSB Fig 2:35 InsP3/DAG recycling


CSB Fig 2:36 PLC structure and function


CSB Fig 2:37 PKC structure and activation


CSB Fig 2:38 Localized inositol lipid signalling


CSB Fig 2:39 PtdIns4,5P2 signalling


CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels


CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels


CSB Fig 2:42 PtdIns 3-kinase signalling


CSB Fig 2:43 Insulin receptor


CSB Fig 2:44 PIKfyve activation

lecture 09 – second messengers iii – cadpribose & inositol lipid signaling biol 5190/6190...

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