lecture 19 – epigenomics – plants lecture 19 – epigenomics – plants biol 5190/6190 cellular...
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Lecture 19 – Epigenomics – Plants
BIOL 5190/6190 Cellular & Molecular Singal TransductionPrepared by Bob Locy
Last modified -13F
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Epigenetics – Stable, but expression-related changes in gene function
1. Methylation of DNA & Histones is involved in epigenetic transcriptional regulation• Correlation between DNA methylation and histone modification• Correlation between gene expression changes and DNA Methylation
2. Transposable elements are regulated by DNA Methylation• Correlation between DNA Methylation and TE transposition
3. How is DNA methylation mediated?• Enzymology known• Transposable elements part of repeat-associated/heterochromatic DNA in
the genome• Repeat associated DNA methylation controls “transposase” function that
mediates transposition, and thus, epigenetic “inheritance”
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Plant Biotic and Abiotic Stress Responses
1. Old time work2. Epigenetic stuff3. State of the Art
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Epigenetic Regulation of Transcription and Transposition
Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510
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Stress Regulated Epigenenic Gene Regulation
Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012
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Proposed model for Epigenetic Control of TE-host coevolution
Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510
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Transducers Second Messengers I
J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.
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CSB Fig 02:01 Cell signalling pathways
J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.